{"Name":"Focal segmental glomerulosclerosis","DiseaseID__c":"GARD:0006517","id":6517,"encodedName":"focal-segmental-glomerulosclerosis","IsDeleted":false,"Disease_Name_Full__c":"Focal segmental glomerulosclerosis","Xref_IDs__c":"236403004; C0017668; C37308; D005923; DOID:1312; HP:0000097; MEDGEN:4904; MONDO:0100313","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":2,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0100313","Disease_Description__c":"A renal disorder characterized by sclerotic lesions in the glomeruli. Causes include drugs, viruses, and malignancies (lymphomas), or it may be idiopathic. It presents with asymptomatic proteinuria or nephritic syndrome and it may lead to renal failure.","GARD_Name__c":"Focal segmental glomerulosclerosis","GARD_Synonym__c":"fgs; fgs - focal glomerulosclerosis; fgs (focal glomerular sclerosis); focal and segmental glomerular sclerosis; focal and segmental glomerulosclerosis; focal glomerular sclerosis; focal glomerulosclerosis; focal sclerosis with hyalinosis; fsgs; fsgs - focal segmental glomerulosclerosis; glomerulosclerosis, focal","Curated_Disease_Description_Source__c":"GARD:0006517","Curated_Disease_Description__c":"Focal segmental glomerulosclerosis (FSGS) is a type of kidney disorder. It is characterized by scar tissue that forms in some of the glomeruli in the kidney. FSGS may cause non-specific signs and symptoms, including protein in the urine, elevated levels of creatinine, and swelling. In many cases the cause of FSGS can not be determined. Some cases are thought to be associated with congenital kidney defects, urine backing up into the kidneys, obesity, obstructive sleep apnea, sickle cell anemia, or viruses (e.g., HIV).","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0100313","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Focal segmental glomerulosclerosis (FSGS) is a type of kidney disorder. It is characterized by scar tissue that forms in some of the glomeruli in the kidney. FSGS may cause non-specific signs and symptoms, including protein in the urine, elevated levels of creatinine, and swelling. In many cases the cause of FSGS can not be determined. Some cases are thought to be associated with congenital kidney defects, urine backing up into the kidneys, obesity, obstructive sleep apnea, sickle cell anemia, or viruses (e.g., HIV).","Curated_Disease_Description_Source__c":"GARD:0006517","GARD_Synonym__c":"fgs; fgs - focal glomerulosclerosis; fgs (focal glomerular sclerosis); focal and segmental glomerular sclerosis; focal and segmental glomerulosclerosis; focal glomerular sclerosis; focal glomerulosclerosis; focal sclerosis with hyalinosis; fsgs; fsgs - focal segmental glomerulosclerosis; glomerulosclerosis, focal","Name":"Focal segmental glomerulosclerosis","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"HealthTree Foundation","Website__c":"https://healthtree.org/"},{"Account_Name__c":"Halpin Foundation","Website__c":"http://www.halpinfoundation.org/index.html"},{"Account_Name__c":"National Kidney Foundation","Website__c":"https://www.kidney.org/"},{"Account_Name__c":"American Association of Kidney Patients","Website__c":"https://www.aakp.org/"},{"Account_Name__c":"NephCure Kidney International","Website__c":"https://nephcure.org/"}],"External_Identifier_Disease__c":[{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=236403004","Source__c":"C0017668; MONDO:0100313","Xref__c":"236403004"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0017668","Source__c":"C0017668","Xref__c":"C0017668"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=4904","Source__c":"C0017668","Xref__c":"MEDGEN:4904"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C37308","Source__c":"C0017668; MONDO:0100313","Xref__c":"C37308"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C005923","Source__c":"C0017668; MONDO:0100313","Xref__c":"D005923"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A1312","Source__c":"MONDO:0100313","Xref__c":"DOID:1312"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0000097","Source__c":"C0017668","Xref__c":"HP:0000097"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=25821008","Source__c":"C0017668","Xref__c":"25821008"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0100313","Source__c":"GARD:0006517","Xref__c":"MONDO:0100313"}],"tags":{},"synonyms":["fgs"," fgs - focal glomerulosclerosis"," fgs (focal glomerular sclerosis)"," focal and segmental glomerular sclerosis"," focal and segmental glomerulosclerosis"," focal glomerular sclerosis"," focal glomerulosclerosis"," focal sclerosis with hyalinosis"," fsgs"," fsgs - focal segmental glomerulosclerosis"," glomerulosclerosis, focal"]}