{"Name":"Chronic hiccup","DiseaseID__c":"GARD:0006657","id":6657,"encodedName":"chronic-hiccup","IsDeleted":false,"Disease_Name_Full__c":"Chronic hiccup","Xref_IDs__c":"716771000; C0744898; MEDGEN:900733; MONDO:0018334; ORPHA:396","USA_Estimate__c":"50,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"80,000 to 800,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0018334","Disease_Description__c":"Chronic hiccup is a rare movement disorder characterized by involuntary spasmodic contractions of the inspiratory muscles synchronized with larynx closure lasting for more than 48 hours.","GARD_Name__c":"Chronic hiccup","GARD_Synonym__c":"chronic hiccough; chronic hiccoughs; chronic hiccups; hiccups, chronic","Curated_Disease_Description_Source__c":"GARD:0006657","Curated_Disease_Description__c":"Chronic hiccups are repeated, unintentional contractions of the breathing muscles that continue for a long period of time. Regular hiccups often develop after eating a large meal or drinking a carbonated beverage, and they typically go away on their own after a couple minutes. Chronic hiccups last over two days and in rare cases, may continue for over a month. Complications of Chronic hiccups can include insomnia, fatigue, weight loss, malnutrition, and depression or anxiety. The exact underlying cause is often unknown; and over 100 different causes of Chronic hiccups have been reported. Diagnosis is based on the symptoms and the duration of the hiccups.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"50,000","Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:396","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0018334","ORPHANET_ID__c":"ORPHA:396","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Hipo crónico","Spanish_Description_Source__c":"ORPHA:396","Spanish_Description__c":"Es un trastorno poco frecuente del movimiento caracterizado por contracciones espasmódicas involuntarias de los músculos inspiratorios sincronizadas con el cierre de la laringe que duran más de 48 horas.","Spanish_Disease_Name__c":"hipo crónico","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:98006","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Chronic hiccups are repeated, unintentional contractions of the breathing muscles that continue for a long period of time. Regular hiccups often develop after eating a large meal or drinking a carbonated beverage, and they typically go away on their own after a couple minutes. Chronic hiccups last over two days and in rare cases, may continue for over a month. Complications of Chronic hiccups can include insomnia, fatigue, weight loss, malnutrition, and depression or anxiety. The exact underlying cause is often unknown; and over 100 different causes of Chronic hiccups have been reported. Diagnosis is based on the symptoms and the duration of the hiccups.","Curated_Disease_Description_Source__c":"GARD:0006657","GARD_Synonym__c":"chronic hiccough; chronic hiccoughs; chronic hiccups; hiccups, chronic","Name":"Chronic hiccup","Curated_USA_Estimate__c":"50,000","estimateUsa":"50,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Smart Patients","Website__c":"https://www.smartpatients.com/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Neurology","Tag_Category__c":"Disease Category;Specialist","category_description":"Neurological diseases affect the brain, spinal cord, cranial nerves, autonomic nerves, or other peripheral nerves.","curated_tag_name":"Neurological diseases"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:396"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=900733","Source__c":"C0744898","Xref__c":"MEDGEN:900733"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=716771000","Source__c":"C0744898; MONDO:0018334","Xref__c":"716771000"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0744898","Source__c":"C0744898","Xref__c":"C0744898"},{"URL__c":"https://www.orpha.net/en/disease/detail/396","Source__c":"C0744898; MONDO:0018334; ORPHA:396","Xref__c":"ORPHA:396"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0018334","Source__c":"GARD:0006657","Xref__c":"MONDO:0018334"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:396","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001944","HPO_Synonym__c":"Dehydration; Exsiccosis","HPO_Name__c":"Dehydration","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:396","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Reduction of total body weight.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001824","HPO_Synonym__c":"Loss of weight","HPO_Name__c":"Weight loss","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:396","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Frequently experiencing feelings of being down, miserable, and/or hopeless; struggling to recover from these moods; having a pessimistic outlook on the future; feeling a pervasive sense of shame; having a low self-worth; experiencing thoughts of suicide and engaging in suicidal behavior.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000716","HPO_Synonym__c":"Depression; Depressive episode; Depressivity","HPO_Name__c":"Depression","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:396","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Abnormal eating habits involve excessive or insufficient consumption of food, or any other abnormal pattern of food consumption.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100738","HPO_Synonym__c":"Abnormal eating behavior","HPO_Name__c":"Abnormal eating behavior","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:396","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An abnormal pattern in the quality, quantity, or characteristics of sleep.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002360","HPO_Synonym__c":"Difficulty sleeping; Sleep abnormality; Sleep disturbances; Sleep dysfunction; Sleep-wake disturbance; Trouble sleeping","HPO_Name__c":"Sleep disturbance","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:396","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"A contraction of the diaphragm that repeats several times per minute. In humans, the abrupt rush of air into the lungs causes the epiglottis to close, creating a hic sound. Also known as synchronous diaphragmatic flutter (SDF), or singultus, from the Latin singult, the act of catching one's breath while sobbing. The hiccup is an involuntary action involving a reflex arc.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100247","HPO_Synonym__c":"Recurrent hiccough; Recurrent hiccup; Recurrent synchronous diaphragmatic flutter","HPO_Name__c":"Recurrent singultus","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:396","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"A deficiency in the intake of energy and nutrients.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0004395","HPO_Synonym__c":"Malnutrition","HPO_Name__c":"Malnutrition","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:396","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Any abnormality of the diaphragm, the sheet of skeletal muscle that separates the thoracic cavity from the abdominal cavity.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000775","HPO_Synonym__c":"Abnormality of the diaphragm; Diaphragm issues; Diaphragmatic defect","HPO_Name__c":"Abnormality of the diaphragm","Feature_System__c":"Musculoskeletal System","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Disease Category":["Neurology"],"Specialist":["Neurology","Pediatrics"]},"synonyms":["chronic hiccough"," chronic hiccoughs"," chronic hiccups"," hiccups, chronic"]}