{"Name":"Inflammatory breast carcinoma","DiseaseID__c":"GARD:0006784","id":6784,"encodedName":"inflammatory-breast-carcinoma","IsDeleted":false,"Disease_Name_Full__c":"Inflammatory breast carcinoma","Xref_IDs__c":"254840009; 423022200; C0278601; C4001; D058922; DOID:6263; MEDGEN:75841; MONDO:0006804; ORPHA:694963","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":1,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":1,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":2,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0006804","Disease_Description__c":"An advanced, invasive breast adenocarcinoma characterized by the presence of distinct changes in the overlying skin. These changes include diffuse erythema, edema, peau d'orange (skin of an orange) appearance, tenderness, induration, warmth, enlargement, and in some cases a palpable mass. The skin changes are the consequence of lymphatic obstruction from the underlying invasive breast adenocarcinoma. Microscopically, the dermal lymphatics show prominent infiltration by malignant cells. The invasive breast adenocarcinoma is usually of ductal, NOS type. There is not significant inflammatory cell infiltrate present, despite the name of this carcinoma.","GARD_Name__c":"Inflammatory breast carcinoma","GARD_Synonym__c":"inflammatory breast cancer; inflammatory carcinoma of breast; inflammatory carcinoma of the breast; mastitis carcinomatosa","Curated_Disease_Description_Source__c":"GARD:0006784","Curated_Disease_Description__c":"Inflammatory breast cancer (IBC) is a type of breast cancer in which the breast looks red and swollen and feels warm. The skin of the breast may also show the pitted appearance called peau d ‘orange (like the skin of an orange). The redness and warmth occur because the cancer cells block the lymph vessels in the skin.\r\n\r\nIBC accounts for 1-5% of all breast cancer cases in the United States. It tends to be diagnosed in younger women compared to non-IBC breast cancer. It occurs more frequently and at a younger age in the African American population than in the White population. Like other types of breast cancer, IBC can occur in men, but usually at an older age than in women.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0006804","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Cáncer de mama inflamatorio","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"cáncer de mama inflamatorio","Spanish_GARD_Synonym__c":"carcinoma de mama inflamatorio; cmi; ibc; icb; mastitis carcinomatosa","Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Inflammatory breast cancer (IBC) is a type of breast cancer in which the breast looks red and swollen and feels warm. The skin of the breast may also show the pitted appearance called peau d ‘orange (like the skin of an orange). The redness and warmth occur because the cancer cells block the lymph vessels in the skin.\r\n\r\nIBC accounts for 1-5% of all breast cancer cases in the United States. It tends to be diagnosed in younger women compared to non-IBC breast cancer. It occurs more frequently and at a younger age in the African American population than in the White population. Like other types of breast cancer, IBC can occur in men, but usually at an older age than in women.","Curated_Disease_Description_Source__c":"GARD:0006784","GARD_Synonym__c":"inflammatory breast cancer; inflammatory carcinoma of breast; inflammatory carcinoma of the breast; mastitis carcinomatosa","Name":"Inflammatory breast carcinoma","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Living Beyond Breast Cancer","Website__c":"https://www.lbbc.org/"},{"Account_Name__c":"SHARE: Cancer Support","Website__c":"https://www.sharecancersupport.org/"},{"Account_Name__c":"Breastcancer.org","Website__c":"https://www.breastcancer.org/"},{"Account_Name__c":"Susan G. Komen","Website__c":"https://www.komen.org/"},{"Account_Name__c":"American Cancer Society","Website__c":"https://www.cancer.org"},{"Account_Name__c":"Inflammatory Breast Cancer Foundation","Website__c":"https://www.eraseibc.org/"},{"Account_Name__c":"The IBC Network Foundation","Website__c":"https://www.theibcnetwork.org/"},{"Account_Name__c":"Tower Cancer Research Foundation","Website__c":"https://www.towercancer.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A6263","Source__c":"MONDO:0006804","Xref__c":"DOID:6263"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=75841","Source__c":"C0278601","Xref__c":"MEDGEN:75841"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C058922","Source__c":"C0278601; MONDO:0006804","Xref__c":"D058922"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0278601","Source__c":"C0278601","Xref__c":"C0278601"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=254840009","Source__c":"C0278601; MONDO:0006804","Xref__c":"254840009"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4001","Source__c":"C0278601; MONDO:0006804","Xref__c":"C4001"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0006804","Source__c":"GARD:0006784","Xref__c":"MONDO:0006804"},{"URL__c":"https://secure.ssa.gov/apps10/poms.nsf/lnx/0423022200","Xref__c":"423022200"},{"URL__c":"https://www.orpha.net/en/disease/detail/694963","Source__c":"MONDO:0006804","Xref__c":"ORPHA:694963"}],"tags":{"Disease Category":["Cancer"]},"synonyms":["inflammatory breast cancer"," inflammatory carcinoma of breast"," inflammatory carcinoma of the breast"," mastitis carcinomatosa"]}