{"Name":"Leiomyosarcoma","DiseaseID__c":"GARD:0006880","id":6880,"encodedName":"leiomyosarcoma","IsDeleted":false,"Disease_Name_Full__c":"Leiomyosarcoma","Xref_IDs__c":"1163022006; 423022961; 443719001; C0023269; C3158; D007890; DOID:1967; HP:0100243; MEDGEN:9711; MONDO:0005058; ORPHA:64720","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":1,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":1,"No_of_Disease_Descriptions__c":4,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":4,"Description_Source__c":"MONDO:0005058","Disease_Description__c":"An uncommon, aggressive malignant smooth muscle neoplasm, usually occurring in post-menopausal women. It is characterized by a proliferation of neoplastic spindle cells. Morphologic variants include epithelioid, granular cell, inflammatory and myxoid leimyosarcomas.","GARD_Name__c":"Leiomyosarcoma","GARD_Synonym__c":"leiomyosarcoma - not uterine; leiomyosarcoma (excluding uterine leiomyosarcoma); leiomyosarcoma, malignant; leiomyosarcomas","Curated_Disease_Description_Source__c":"GARD:0006880","Curated_Disease_Description__c":"Leiomyosarcoma is a rare cancerous tumor that consists of smooth (involuntary) muscle cells. Leiomyosarcoma is a type of sarcoma. It spreads through the blood stream and can affect the lungs, liver, blood vessels, or any other soft tissue in the body. The exact cause of Leiomyosarcoma is not known, although genetic and environmental factors appear to be involved. It is most often found in the uterus or abdomen.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"at a variety of ages","SourceID__c":"ORPHA:64720","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0005058","ORPHANET_ID__c":"ORPHA:64720","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Leiomiosarcoma","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"leiomiosarcoma","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Leiomyosarcoma is a rare cancerous tumor that consists of smooth (involuntary) muscle cells. Leiomyosarcoma is a type of sarcoma. It spreads through the blood stream and can affect the lungs, liver, blood vessels, or any other soft tissue in the body. The exact cause of Leiomyosarcoma is not known, although genetic and environmental factors appear to be involved. It is most often found in the uterus or abdomen.","Curated_Disease_Description_Source__c":"GARD:0006880","GARD_Synonym__c":"leiomyosarcoma - not uterine; leiomyosarcoma (excluding uterine leiomyosarcoma); leiomyosarcoma, malignant; leiomyosarcomas","Name":"Leiomyosarcoma","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Sarcoma UK","Website__c":"https://sarcoma.org.uk/"},{"Account_Name__c":"Sarcoma Foundation of America","Website__c":"https://www.curesarcoma.org/"},{"Account_Name__c":"Rare Cancers Australia","Website__c":"http://rarecancers.org.au/"},{"Account_Name__c":"American Cancer Society","Website__c":"https://www.cancer.org"},{"Account_Name__c":"National LeioMyoSarcoma Foundation","Website__c":"https://nlmsf.org/"},{"Account_Name__c":"Leiomyosarcoma Support & Direct Research Foundation","Website__c":"https://lmsdr.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Elderly","Provided_By__c":"ORPHA:64720"},{"Age_At_Onset__c":"Adolescent","Provided_By__c":"ORPHA:64720"},{"Age_At_Onset__c":"Childhood","Provided_By__c":"ORPHA:64720"},{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:64720"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0023269","Source__c":"C0023269","Xref__c":"C0023269"},{"URL__c":"https://www.orpha.net/en/disease/detail/64720","Source__c":"C0023269; MONDO:0005058; ORPHA:64720","Xref__c":"ORPHA:64720"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3158","Source__c":"C0023269; MONDO:0005058","Xref__c":"C3158"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C007890","Source__c":"MONDO:0005058","Xref__c":"D007890"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=443719001","Source__c":"C0023269; MONDO:0005058","Xref__c":"443719001"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=9711","Source__c":"C0023269","Xref__c":"MEDGEN:9711"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A1967","Source__c":"MONDO:0005058","Xref__c":"DOID:1967"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=1163022006","Source__c":"C0023269","Xref__c":"1163022006"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0100243","Source__c":"C0023269","Xref__c":"HP:0100243"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0005058","Source__c":"GARD:0006880","Xref__c":"MONDO:0005058"},{"URL__c":"https://secure.ssa.gov/apps10/poms.nsf/lnx/0423022961","Xref__c":"423022961"}],"tags":{"Specialist":["Cancer - Oncologist","Pediatrics"],"Disease Category":["Cancer"]},"synonyms":["leiomyosarcoma - not uterine"," leiomyosarcoma (excluding uterine leiomyosarcoma)"," leiomyosarcoma, malignant"," leiomyosarcomas"]}