{"Name":"Light chain deposition disease","DiseaseID__c":"GARD:0006906","id":6906,"encodedName":"light-chain-deposition-disease","IsDeleted":false,"Disease_Name_Full__c":"Light chain deposition disease","Xref_IDs__c":"373604002; C0238239; C7727; MEDGEN:65953; MONDO:0019730; ORPHA:93558","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0019730","Disease_Description__c":"Light chain deposition disease (LCDD) is a rare condition characterized by the deposition of specific proteins (monoclonal light chains) in the kidneys and other organs. Light chains are used to make antibodies that the body needs to fight infection. People with LCDD make too many light chains, which get deposited in many body tissues. While LCDD can occur in any organ, the kidneys are always involved. Signs and symptoms of LCDD may include protein in the urine ; decreased kidney function; and/or nephrotic syndrome. Rarely, a person with LCDD may have symptoms from cardiac (heart) or liver involvement. The underlying cause of LCDD is unknown. It is often associated with multiple myeloma. LCDD may progress to multiple myeloma, or it may be present with multiple myeloma when it is first diagnosed. The goal of treating LCDD is to slow the production of light chains and their damage to organs. Treatment may include chemotherapy with a drug called Bortezomib ; autologous stem cell transplantation ; immunomodulatory drugs; and/or kidney transplant. If untreated, end-stage renal disease occurs in 70% of cases.","GARD_Name__c":"Light chain deposition disease","GARD_Synonym__c":"bence jones myeloma; lcdd; light chain disease; light chain gammopathy","Curated_Disease_Description_Source__c":"GARD:0006906","Curated_Disease_Description__c":"Light chain deposition disease (LCDD) is a rare condition characterized by the deposition of specific proteins (monoclonal light chains) in the kidneys and other organs. Light chains are used to make antibodies that the body needs to fight infection. People with LCDD make too many light chains, which get deposited in many body tissues. While LCDD can occur in any organ, the kidneys are always involved. Signs and symptoms of LCDD may include protein in the urine; decreased kidney function; and/or nephrotic syndrome. Rarely, a person with LCDD may have symptoms from cardiac (heart) or liver involvement. The underlying cause of LCDD is unknown. It is often associated with multiple myeloma. LCDD may progress to multiple myeloma, or it may be present with multiple myeloma when it is first diagnosed.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":"ORPHA:93558","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0019730","ORPHANET_ID__c":"ORPHA:93558","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Enfermedad por depósito de cadenas ligeras","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"enfermedad por depósito de cadenas ligeras","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Light chain deposition disease (LCDD) is a rare condition characterized by the deposition of specific proteins (monoclonal light chains) in the kidneys and other organs. Light chains are used to make antibodies that the body needs to fight infection. People with LCDD make too many light chains, which get deposited in many body tissues. While LCDD can occur in any organ, the kidneys are always involved. Signs and symptoms of LCDD may include protein in the urine; decreased kidney function; and/or nephrotic syndrome. Rarely, a person with LCDD may have symptoms from cardiac (heart) or liver involvement. The underlying cause of LCDD is unknown. It is often associated with multiple myeloma. LCDD may progress to multiple myeloma, or it may be present with multiple myeloma when it is first diagnosed.","Curated_Disease_Description_Source__c":"GARD:0006906","GARD_Synonym__c":"bence jones myeloma; lcdd; light chain disease; light chain gammopathy","Name":"Light chain deposition disease","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"American Cancer Society","Website__c":"https://www.cancer.org"},{"Account_Name__c":"Blood Cancer United","Website__c":"https://bloodcancerunited.org/"},{"Account_Name__c":"International Myeloma Foundation","Website__c":"https://www.myeloma.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Nephrology","Tag_Category__c":"Account;Disease Category;Specialist","category_description":"Kidney diseases affect the kidneys' ability to remove waste and water from blood, create urine, or make certain hormones.","curated_tag_name":"Kidney diseases"},{"Tag_Name__c":"Hematology","Tag_Category__c":"Disease Category;Specialist","category_description":"Blood diseases affect the blood or blood-forming organs, including red blood cells, white blood cells, platelets, plasma, and bone marrow.","curated_tag_name":"Blood diseases"}],"External_Identifier_Disease__c":[{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=373604002","Source__c":"C0238239; MONDO:0019730","Xref__c":"373604002"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C7727","Source__c":"C0238239; MONDO:0019730","Xref__c":"C7727"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0238239","Source__c":"C0238239","Xref__c":"C0238239"},{"URL__c":"https://www.orpha.net/en/disease/detail/93558","Source__c":"C0238239; MONDO:0019730; ORPHA:93558","Xref__c":"ORPHA:93558"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=65953","Source__c":"C0238239","Xref__c":"MEDGEN:65953"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=51319002","Source__c":"C0238239","Xref__c":"51319002"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0019730","Source__c":"GARD:0006906","Xref__c":"MONDO:0019730"}],"tags":{"Specialist":["Cancer - Oncologist","Nephrology","Hematology"],"Disease Category":["Cancer","Nephrology","Hematology"],"Account":["Nephrology"]},"synonyms":["bence jones myeloma"," lcdd"," light chain disease"," light chain gammopathy"]}