{"Name":"Mal de Debarquement","DiseaseID__c":"GARD:0006959","id":6959,"encodedName":"mal-de-debarquement","IsDeleted":false,"Disease_Name_Full__c":"Mal de Debarquement","Xref_IDs__c":"446079007; C1608983; C537840; MEDGEN:345629; MONDO:0016217; ORPHA:210272","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0016217","Disease_Description__c":"Mal de débarquement (MdD) is a rare otorhinolaryngological disease characterized by a persistent sensation of motion such as rocking, swaying, tumbling and/or bobbing following a period of exposure to passive movement, usually an ocean cruise or other types of water, train, automobile or air travel and less commonly other movements (like sleeping on a waterbed). Onset may be spontaneous in some patients. Manifestations begin shortly after the stimulus, persist for 6 months to years and may be associated with anxiety, fatigue and impaired cognition. Symptoms are often accentuated when in an enclosed space or when attempting to be motionless (sitting, lying down or standing in a stationary position) and are relieved when in passive motion such as in a moving car, airplane or train.","GARD_Name__c":"Mal de Debarquement","GARD_Synonym__c":"disembarkment syndrome; mal de debarquement syndrome; mal de débarquement; mdd; mdds; sickness of disembarkment","Curated_Disease_Description_Source__c":"GARD:0006959","Curated_Disease_Description__c":"Mal de debarquement syndrome is a neurological disorder that most commonly develops following an ocean cruise or other type of water travel and less commonly following air travel, train travel, or other motion experiences. The symptoms typically reported include: persistent sensation of motion such as rocking, swaying, and/or bobbing, difficulty maintaining balance, anxiety, fatigue, unsteadiness, and difficulty concentrating. Symptoms may or may not go away with time; however, they may reoccur following another motion experience or during periods of stress or illness.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:210272","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0016217","ORPHANET_ID__c":"ORPHA:210272","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Enfermedad del desembarco","Spanish_Description_Source__c":"ORPHA:210272","Spanish_Description__c":"Es una enfermedad otorrinolaringológica poco frecuente caracterizada por una sensación persistente de movimiento, como mecerse, balancearse y/o dar vueltas después de un período de exposición al movimiento pasivo, generalmente un crucero marítimo o de otro tipo, desplazamientos en tren, automóvil o avión y, con menor frecuencia, otros movimientos (como dormir en una cama de agua). El inicio puede ser espontáneo en algunos pacientes. Las manifestaciones comienzan poco después del estímulo, persisten durante 6 meses a años y pueden estar asociadas con ansiedad, cansancio y afectación cognitiva. Los síntomas se suelen acentuar en espacios cerrados o cuando se intenta estar inmóvil (sentado, acostado o de pie en una posición estacionaria) y se alivian cuando se está en movimiento pasivo, como en un automóvil, avión o tren en marcha.","Spanish_Disease_Name__c":"enfermedad del desembarco","Spanish_GARD_Synonym__c":"mdd; mdds; síndrome 'mal de débarquement'; síndrome del desembarco","Category_Linearization__c":"ORPHA:98036","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Mal de debarquement syndrome is a neurological disorder that most commonly develops following an ocean cruise or other type of water travel and less commonly following air travel, train travel, or other motion experiences. The symptoms typically reported include: persistent sensation of motion such as rocking, swaying, and/or bobbing, difficulty maintaining balance, anxiety, fatigue, unsteadiness, and difficulty concentrating. Symptoms may or may not go away with time; however, they may reoccur following another motion experience or during periods of stress or illness.","Curated_Disease_Description_Source__c":"GARD:0006959","GARD_Synonym__c":"disembarkment syndrome; mal de debarquement syndrome; mal de débarquement; mdd; mdds; sickness of disembarkment","Name":"Mal de Debarquement","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"MdDS Foundation","Website__c":"https://mddsfoundation.org/"},{"Account_Name__c":"Vestibular Disorders Association","Website__c":"https://vestibular.org/"},{"Account_Name__c":"Ménière's Society","Website__c":"https://www.menieres.org.uk/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Otolaryngology","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:210272"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C1608983","Source__c":"C1608983","Xref__c":"C1608983"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C537840","Source__c":"MONDO:0016217","Xref__c":"C537840"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=345629","Source__c":"C1608983","Xref__c":"MEDGEN:345629"},{"URL__c":"https://www.orpha.net/en/disease/detail/210272","Source__c":"C1608983; MONDO:0016217; ORPHA:210272","Xref__c":"ORPHA:210272"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=446079007","Source__c":"C1608983; MONDO:0016217","Xref__c":"446079007"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0016217","Source__c":"GARD:0006959","Xref__c":"MONDO:0016217"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:210272","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Diplopia is a condition in which a single object is perceived as two images, it is also known as double vision.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000651","HPO_Synonym__c":"Double vision","HPO_Name__c":"Diplopia","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:210272","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Intense feelings of nervousness, tension, or panic often arise in response to interpersonal stresses. There is worry about the negative effects of past unpleasant experiences and future negative possibilities. Individuals may feel fearful, apprehensive, or threatened by uncertainty, and they may also have fears of falling apart or losing control.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000739","HPO_Synonym__c":"Anxiety; Anxiousness; Excessive, persistent worry and fear","HPO_Name__c":"Anxiety","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:210272","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002013","HPO_Synonym__c":"Emesis; Throwing up; Vomiting","HPO_Name__c":"Vomiting","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:210272","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A subjective feeling of tiredness characterized by a lack of energy and motivation.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012378","HPO_Synonym__c":"Fatigue; Tired; Tiredness","HPO_Name__c":"Fatigue","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:210272","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Lack of clarity and coherence of thought, perception, understanding, or action.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001289","HPO_Synonym__c":"Confusion; Disorientation; Easily confused; Mental disorientation","HPO_Name__c":"Confusion","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:210272","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Tiny, repetitive muscle contractions in the eyelids, causing the appearance of twitching.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0030826","HPO_Synonym__c":"Eyelid fluttering; Fasciculation of the eyelid; Muscle twitches in eye lid; Muscle twitches in eyelid; Twitching around eyes","HPO_Name__c":"Eyelid fasciculation","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:210272","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A sensation of unease in the stomach together with an urge to vomit.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002018","HPO_Synonym__c":"Nausea","HPO_Name__c":"Nausea","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:210272","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002076","HPO_Synonym__c":"Intermittent migraine headaches; Migraine; Migraine headache; Migraine headaches","HPO_Name__c":"Migraine","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:210272","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002315","HPO_Synonym__c":"Headache; Headaches","HPO_Name__c":"Headache","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:210272","HPO_Frequency__c":"Excluded (0%)","Feature__r":{"HPO_Description__c":"An abnormality of the vestibulo-ocular reflex (VOR). The VOR attempts to keep the image stable on the retina. Ideally passive or active head movements in one direction are compensated for by eye movements of equal magnitude.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0007670","HPO_Synonym__c":"Abnormal vestibuloocular reflex","HPO_Name__c":"Abnormal vestibulo-ocular reflex","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:210272","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"A tendency to fall or the inability to keep oneself from falling; imbalance. The retropulsion test is widely regarded as the gold standard to evaluate postural instability, Use of the retropulsion test includes a rapid balance perturbation in the backward direction, and the number of balance correcting steps (or total absence thereof) is used to rate the degree of postural instability. Healthy subjects correct such perturbations with either one or two large steps, or without taking any steps, hinging rapidly at the hips while swinging the arms forward as a counterweight. In patients with balance impairment, balance correcting steps are often too small, forcing patients to take more than two steps. Taking three or more steps is generally considered to be abnormal, and taking more than five steps is regarded as being clearly abnormal. Markedly affected patients continue to step backward without ever regaining their balance and must be caught by the examiner (this would be called true retropulsion). Even more severely affected patients fail to correct entirely, and fall backward like a pushed toy soldier, without taking any corrective steps.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002172","HPO_Synonym__c":"Balance impairment","HPO_Name__c":"Postural instability","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:210272","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002317","HPO_Synonym__c":"Gait instability; Unsteady walk","HPO_Name__c":"Unsteady gait","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:210272","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An abnormality in voluntary or involuntary eye movements or their control.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000496","HPO_Synonym__c":"Abnormal extraocular movement; Abnormal extraocular movements; Abnormal eye motility; Abnormal eye movement; Abnormal eye movements; Abnormal motility of the globe of the eye; Abnormal movement of the globe of the eye; Abnormal ocular movements; Abnormality of eye movement; Eye movement abnormalities; Eye movement issue; Ocular movement abnormalities; Oculomotor abnormalities","HPO_Name__c":"Abnormality of eye movement","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:210272","HPO_Frequency__c":"Excluded (0%)","Feature__r":{"HPO_Description__c":"An anomaly of metabolism or structure of the brain identified by imaging.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0410263","HPO_Synonym__c":"Abnormal brain imaging","HPO_Name__c":"Brain imaging abnormality","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:210272","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Lack of sharpness of vision resulting in the inability to see fine detail.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000622","HPO_Synonym__c":"Blurred vision","HPO_Name__c":"Blurred vision","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:210272","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002141","HPO_Synonym__c":"Abnormality of balance; Abnormality of equilibrium; Imbalanced walk","HPO_Name__c":"Gait imbalance","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:210272","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An abnormal sensation of spinning while the body is actually stationary.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002321","HPO_Synonym__c":"Dizzy spell","HPO_Name__c":"Vertigo","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Specialist":["Otolaryngology","Pediatrics"]},"synonyms":["disembarkment syndrome"," mal de debarquement syndrome"," mal de débarquement"," mdd"," mdds"," sickness of disembarkment"]}