{"Name":"Malignant fibrous histiocytoma","DiseaseID__c":"GARD:0006963","id":6963,"encodedName":"malignant-fibrous-histiocytoma","IsDeleted":false,"Disease_Name_Full__c":"Malignant fibrous histiocytoma","Xref_IDs__c":"443439001; C0334463; C114541; C4247; D051677; DOID:1907; MEDGEN:87248; MONDO:0002142; ORPHA:2023","USA_Estimate__c":"5,000","No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"8,000 to 80,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":4,"Description_Source__c":"MONDO:0002142","Disease_Description__c":"An undifferentiated soft tissue sarcoma characterized by the presence of a pleomorphic malignant cellular infiltrate. It is also known as malignant fibrous histiocytoma.","GARD_Name__c":"Malignant fibrous histiocytoma","GARD_Synonym__c":"adult malignant fibrous histiocytoma; adult unclassified pleomorphic sarcoma; adult undifferentiated pleomorphic sarcoma; fibrous histiocytoma, malignant; fibrous histiocytoma, malignant (morphologic abnormality); fibroxanthoma, malignant; fibroxanthosarcoma; fibroxanthosarcoma (morphologic abnormality); histiocytoma, fibrous, malignant; malignant fibrohistiocytic tumors; malignant fibrous cytoma; malignant fibrous histiocytoma of soft tissue and bone; malignant fibrous histiocytoma of the soft tissue and bone; malignant fibroxanthoma; mfh; storiform-pleomorphic fibrous histiocytoma; storiform-pleomorphic malignant fibrous histiocytoma; storiform-pleomorphic mfh; unclassified pleomorphic sarcoma; unclassified pleomorphic sarcoma (formerly \"malignant fibrous histiocytoma\"); unclassified pleomorphic sarcoma (formerly \"mfh\"); undifferentiated high grade pleomorphic sarcoma; undifferentiated pleomorphic sarcoma; undifferentiated pleomorphic soft tissue sarcoma; ups","Curated_Disease_Description_Source__c":"MONDO:0002142","Curated_Disease_Description__c":"An undifferentiated soft tissue sarcoma characterized by the presence of a pleomorphic malignant cellular infiltrate. It is also known as malignant fibrous histiocytoma.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"5,000","Age_at_Onset_Snippet_Text__c":"at a variety of ages","SourceID__c":"ORPHA:2023","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0002142","ORPHANET_ID__c":"ORPHA:2023","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Sarcoma pleomórfico indiferenciado","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"sarcoma pleomórfico indiferenciado","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"An undifferentiated soft tissue sarcoma characterized by the presence of a pleomorphic malignant cellular infiltrate. It is also known as malignant fibrous histiocytoma.","Curated_Disease_Description_Source__c":"MONDO:0002142","GARD_Synonym__c":"adult malignant fibrous histiocytoma; adult unclassified pleomorphic sarcoma; adult undifferentiated pleomorphic sarcoma; fibrous histiocytoma, malignant; fibrous histiocytoma, malignant (morphologic abnormality); fibroxanthoma, malignant; fibroxanthosarcoma; fibroxanthosarcoma (morphologic abnormality); histiocytoma, fibrous, malignant; malignant fibrohistiocytic tumors; malignant fibrous cytoma; malignant fibrous histiocytoma of soft tissue and bone; malignant fibrous histiocytoma of the soft tissue and bone; malignant fibroxanthoma; mfh; storiform-pleomorphic fibrous histiocytoma; storiform-pleomorphic malignant fibrous histiocytoma; storiform-pleomorphic mfh; unclassified pleomorphic sarcoma; unclassified pleomorphic sarcoma (formerly \"malignant fibrous histiocytoma\"); unclassified pleomorphic sarcoma (formerly \"mfh\"); undifferentiated high grade pleomorphic sarcoma; undifferentiated pleomorphic sarcoma; undifferentiated pleomorphic soft tissue sarcoma; ups","Name":"Malignant fibrous histiocytoma","Curated_USA_Estimate__c":"5,000","estimateUsa":"5,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"The Skin Cancer Foundation","Website__c":"https://www.skincancer.org/"},{"Account_Name__c":"Sarcoma UK","Website__c":"https://sarcoma.org.uk/"},{"Account_Name__c":"American Cancer Society","Website__c":"https://www.cancer.org"},{"Account_Name__c":"Sarcoma Alliance for Research through Collaboration","Website__c":"https://sarctrials.org"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Orthopedics","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Elderly","Provided_By__c":"ORPHA:2023"},{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:2023"},{"Age_At_Onset__c":"Childhood","Provided_By__c":"ORPHA:2023"},{"Age_At_Onset__c":"Adolescent","Provided_By__c":"ORPHA:2023"}],"External_Identifier_Disease__c":[{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4247","Source__c":"C0334463; MONDO:0002142","Xref__c":"C4247"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=87248","Source__c":"C0334463","Xref__c":"MEDGEN:87248"},{"URL__c":"https://www.orpha.net/en/disease/detail/2023","Source__c":"C0334463; MONDO:0002142; ORPHA:2023","Xref__c":"ORPHA:2023"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C051677","Source__c":"C0334463; MONDO:0002142","Xref__c":"D051677"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0334463","Source__c":"C0334463","Xref__c":"C0334463"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C114541","Source__c":"MONDO:0002142","Xref__c":"C114541"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=443439001","Source__c":"C0334463; MONDO:0002142","Xref__c":"443439001"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A1907","Source__c":"MONDO:0002142","Xref__c":"DOID:1907"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0002142","Source__c":"GARD:0006963","Xref__c":"MONDO:0002142"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=34360000","Source__c":"C0334463","Xref__c":"34360000"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:2023","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"An abnormality of the leg.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002814","HPO_Synonym__c":"Abnormality of the leg; Abnormality of the lower limb; Lower limb deformities","HPO_Name__c":"Abnormality of the lower limb","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:2023","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Abnormality originating in one or more muscles, i.e., of the set of muscles of body.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0003011","HPO_Synonym__c":"Muscular abnormality","HPO_Name__c":"Abnormality of the musculature","Feature_System__c":"Musculoskeletal System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:2023","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A subjective feeling of tiredness characterized by a lack of energy and motivation.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012378","HPO_Synonym__c":"Fatigue; Tired; Tiredness","HPO_Name__c":"Fatigue","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:2023","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"A type of sarcoma (A connective tissue neoplasm formed by proliferation of mesodermal cells) that develops from soft tissues like fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0030448","HPO_Synonym__c":"Soft tissue sarcomas","HPO_Name__c":"Soft tissue sarcoma","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:2023","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An abnormality of the arm.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002817","HPO_Synonym__c":"Abnormality of the arm; Abnormality of the upper limb","HPO_Name__c":"Abnormality of the upper limb","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:2023","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Body temperature elevated above the normal range.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001945","HPO_Synonym__c":"Fever; Hyperthermia; Pyrexia","HPO_Name__c":"Fever","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:2023","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Lack of desire to eat (loss of appetite).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002039","HPO_Synonym__c":"Anorexia; Deliberately not eating; Obsessive dieting; Refusing to eat","HPO_Name__c":"Anorexia","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:2023","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Reduction of total body weight.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001824","HPO_Synonym__c":"Loss of weight","HPO_Name__c":"Weight loss","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:2023","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"An abnormality of the peritoneum.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002585","HPO_Synonym__c":"Abnormality of the peritoneum","HPO_Name__c":"Abnormal peritoneum morphology","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Specialist":["Cancer - Oncologist","Orthopedics","Pediatrics"],"Disease Category":["Cancer"]},"synonyms":["adult malignant fibrous histiocytoma"," adult unclassified pleomorphic sarcoma"," adult undifferentiated pleomorphic sarcoma"," fibrous histiocytoma, malignant"," fibrous histiocytoma, malignant (morphologic abnormality)"," fibroxanthoma, malignant"," fibroxanthosarcoma"," fibroxanthosarcoma (morphologic abnormality)"," histiocytoma, fibrous, malignant"," malignant fibrohistiocytic tumors"," malignant fibrous cytoma"," malignant fibrous histiocytoma of soft tissue and bone"," malignant fibrous histiocytoma of the soft tissue and bone"," malignant fibroxanthoma"," mfh"," storiform-pleomorphic fibrous histiocytoma"," storiform-pleomorphic malignant fibrous histiocytoma"," storiform-pleomorphic mfh"," unclassified pleomorphic sarcoma"," unclassified pleomorphic sarcoma (formerly \"malignant fibrous histiocytoma\")"," unclassified pleomorphic sarcoma (formerly \"mfh\")"," undifferentiated high grade pleomorphic sarcoma"," undifferentiated pleomorphic sarcoma"," undifferentiated pleomorphic soft tissue sarcoma"," ups"]}