{"Name":"Mesothelioma, malignant","DiseaseID__c":"GARD:0007026","id":7026,"encodedName":"mesothelioma-malignant","IsDeleted":false,"Disease_Name_Full__c":"Mesothelioma, malignant","Xref_IDs__c":"109378008; 62064005; C0345967; C4456; C562839; DOID:1790; MEDGEN:91062; MONDO:0006292; OMIM:156240; ORPHA:50251","USA_Estimate__c":"50,000","No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":2,"World_Estimate__c":"80,000 to 800,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":2,"No_of_Disease_Descriptions__c":4,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0006292","Disease_Description__c":"A malignant neoplasm of the pleura or peritoneum, arising from mesothelial cells. It is associated with exposure to asbestos.","GARD_Name__c":"Mesothelioma, malignant","GARD_Synonym__c":"cancer, mesothelioma; malignant mesothelial tumor; malignant mesothelial tumour; malignant mesothelioma; malignant mesothelioma (disease); malignant neoplasm of mesothelium; malignant neoplasm of the mesothelium; malignant tumor of mesothelium; malignant tumor of the mesothelium; malignant tumour of mesothelium; malignant tumour of the mesothelium; mesom; mesothelioma (malignant, clinical disorder); mesothelioma, somatic; pleural mesothelioma","Curated_Disease_Description_Source__c":"GARD:0007026","Curated_Disease_Description__c":"Pleural mesothelioma is a form of cancer that develops in the thin layer of tissue that surrounds the lungs, chest wall, or abdomen. Signs and symptoms of the condition can vary and often depend on which area of the body is affected. Common features include abdominal bloating, abdominal pain, chest pain, coughing, fatigue, shortness of breath, and/or weight loss. Pleural mesothelioma is thought to be caused by long-term exposure to asbestos (a fire-resistant material that was once commonly found in insulation; ceiling and roof vinyls; cement; and automotive brake materials). If surgery is not an option, chemotherapy and/or radiation therapy may still be recommended to help alleviate some of the associated symptoms.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"50,000","Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:50251","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0006292","ORPHANET_ID__c":"ORPHA:50251","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Mesotelioma pleural","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"mesotelioma pleural","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Pleural mesothelioma is a form of cancer that develops in the thin layer of tissue that surrounds the lungs, chest wall, or abdomen. Signs and symptoms of the condition can vary and often depend on which area of the body is affected. Common features include abdominal bloating, abdominal pain, chest pain, coughing, fatigue, shortness of breath, and/or weight loss. Pleural mesothelioma is thought to be caused by long-term exposure to asbestos (a fire-resistant material that was once commonly found in insulation; ceiling and roof vinyls; cement; and automotive brake materials). If surgery is not an option, chemotherapy and/or radiation therapy may still be recommended to help alleviate some of the associated symptoms.","Curated_Disease_Description_Source__c":"GARD:0007026","GARD_Synonym__c":"cancer, mesothelioma; malignant mesothelial tumor; malignant mesothelial tumour; malignant mesothelioma; malignant mesothelioma (disease); malignant neoplasm of mesothelium; malignant neoplasm of the mesothelium; malignant tumor of mesothelium; malignant tumor of the mesothelium; malignant tumour of mesothelium; malignant tumour of the mesothelium; mesom; mesothelioma (malignant, clinical disorder); mesothelioma, somatic; pleural mesothelioma","Name":"Mesothelioma, malignant","Curated_USA_Estimate__c":"50,000","estimateUsa":"50,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Mesothelioma Guide","Website__c":"https://www.mesotheliomaguide.com/"},{"Account_Name__c":"Mesothelioma.net","Website__c":"https://mesothelioma.net/"},{"Account_Name__c":"American Cancer Society","Website__c":"https://www.cancer.org"},{"Account_Name__c":"American Lung Association","Website__c":"https://www.lung.org/"},{"Account_Name__c":"Mesothelioma Applied Research Foundation","Website__c":"https://www.curemeso.org/"},{"Account_Name__c":"Mesothelioma.com","Website__c":"https://www.mesothelioma.com/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Pulmonology","Tag_Category__c":"Disease Category;Specialist","category_description":"Respiratory diseases affect the nose, mouth, throat, voice box, windpipe, lungs, or blood vessels.","curated_tag_name":"Respiratory diseases"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:50251"}],"Diagnosis__c":[{"Type__c":"GTR","Curie__c":"MEDGEN:C0025500"},{"Type__c":"GTR","Curie__c":"MEDGEN:C0345967"}],"External_Identifier_Disease__c":[{"URL__c":"https://raresource.nih.gov/diseases/filter/0007026","Source__c":"RareSource"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A1790","Source__c":"MONDO:0006292","Xref__c":"DOID:1790"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=91062","Source__c":"C0345967","Xref__c":"MEDGEN:91062"},{"URL__c":"https://www.omim.org/entry/156240","Source__c":"C0345967; MONDO:0006292; ORPHA:50251","Xref__c":"OMIM:156240"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4456","Source__c":"C0345967; MONDO:0006292","Xref__c":"C4456"},{"URL__c":"https://www.orpha.net/en/disease/detail/50251","Source__c":"C0345967; MONDO:0006292","Xref__c":"ORPHA:50251"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C562839","Source__c":"MONDO:0006292","Xref__c":"C562839"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=109378008","Source__c":"C0345967; MONDO:0006292","Xref__c":"109378008"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0345967","Source__c":"C0345967","Xref__c":"C0345967"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0006292","Source__c":"GARD:0007026","Xref__c":"MONDO:0006292"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=62064005","Source__c":"C0345967","Xref__c":"62064005"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0100001","Source__c":"C0345967","Xref__c":"HP:0100001"},{"URL__c":"https://www.cancer.gov/types/mesothelioma"},{"URL__c":"https://www.cancer.gov/types/mesothelioma/patient/mesothelioma-treatment-pdq"}],"GARD_Disease_Gene__c":[{"GeneSymbol__c":"BCL10","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"WT1","GHR_URL__c":"https://medlineplus.gov/genetics/gene/wt1","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:50251","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Reduction of total body weight.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001824","HPO_Synonym__c":"Loss of weight","HPO_Name__c":"Weight loss","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50251","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An abnormality of the pulmonary pleura, the thin, transparent membrane which covers the lungs and lines the inside of the chest walls.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002103","HPO_Synonym__c":"Abnormality of the pleura","HPO_Name__c":"Abnormal pleura morphology","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50251","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"The presence of an excessive amount of fluid in the pleural cavity.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002202","HPO_Synonym__c":"Fluid around lungs","HPO_Name__c":"Pleural effusion","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50251","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Abnormally increased size of the liver.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002240","HPO_Synonym__c":"Enlarged liver","HPO_Name__c":"Hepatomegaly","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50251","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the chest.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100749","HPO_Synonym__c":"Chest pain; Thoracic pain","HPO_Name__c":"Chest pain","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50251","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Respiratory distress is objectively observable as the physical or emotional consequences from the experience of dyspnea. The physical presentation of respiratory distress is generally referred to as labored breathing, while the sensation of respiratory distress is called shortness of breath or dyspnea.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002098","HPO_Synonym__c":"Breathing difficulties; Labored breathing; Respiratory difficulties","HPO_Name__c":"Respiratory distress","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50251","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Abnormal function of the respiratory system.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002795","HPO_Synonym__c":"Abnormal respiration; Functional respiratory abnormality","HPO_Name__c":"Abnormal respiratory system physiology","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50251","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Any abnormality of the thorax (the region of the body formed by the sternum, the thoracic vertebrae and the ribs).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000765","HPO_Synonym__c":"Abnormality of the chest; Abnormality of the thorax; Structural abnormality of the chest wall","HPO_Name__c":"Abnormal thorax morphology","Feature_System__c":"Musculoskeletal System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50251","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Any structural anomaly of the lung.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002088","HPO_Synonym__c":"Abnormality of lung structure; Abnormality of the lungs; Abnormally shaped lung; Unusual lung shape","HPO_Name__c":"Abnormal lung morphology","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50251","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Abnormal functionality of the cardiovascular system.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0011025","HPO_Synonym__c":"Abnormality of cardiovascular system physiology","HPO_Name__c":"Abnormal cardiovascular system physiology","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50251","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Difficulty in swallowing.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002015","HPO_Synonym__c":"Difficulty swallowing; Poor swallowing; Swallowing difficulties; Swallowing difficulty","HPO_Name__c":"Dysphagia","Feature_System__c":"Nervous System; Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50251","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Blockage of blood flow through the superior vena cava (SVC). Because the venous drainage from the upper extremities, upper thorax and head is obstructed, SVC obstruction presents with symptoms related to engorgement of these areas. Both the degree of SVC compromise and the extent of collateral veins determine the varied clinical presentation, which can be as mild as slight facial and upper extremity edema or as dire as intracranial swelling, seizures, hemodynamic instability and tracheal obstruction.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0031041","HPO_Synonym__c":"Superior vena cava obstruction","HPO_Name__c":"Obstruction of the superior vena cava","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50251","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0025142","HPO_Name__c":"Constitutional symptom","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50251","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Enlargement (swelling) of a lymph node.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002716","HPO_Synonym__c":"Lymph node hyperplasia; Swollen lymph nodes","HPO_Name__c":"Lymphadenopathy","Feature_System__c":"Cardiovascular System; Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50251","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Paralysis of the fourth cranial (trochlear) nerve manifested as weakness of the superior oblique muscle which causes vertical diplopia that is maximal when the affected eye is adducted and directed inferiorly.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0007011","HPO_Synonym__c":"Trochlear nerve palsy","HPO_Name__c":"Fourth cranial nerve palsy","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50251","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Difficult or labored breathing. Dyspnea is a subjective feeling only the patient can rate, e.g., on a Borg scale.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002094","HPO_Synonym__c":"Abnormal breathing; Breathing difficulty; Difficult to breathe; Difficulty breathing; Shortness of breath; Trouble breathing","HPO_Name__c":"Dyspnea","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50251","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012735","HPO_Synonym__c":"Cough; Coughing","HPO_Name__c":"Cough","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Specialist":["Cancer - Oncologist","Pulmonology","Pediatrics"],"Disease Category":["Cancer","Pulmonology"]},"synonyms":["cancer, mesothelioma"," malignant mesothelial tumor"," malignant mesothelial tumour"," malignant mesothelioma"," malignant mesothelioma (disease)"," malignant neoplasm of mesothelium"," malignant neoplasm of the mesothelium"," malignant tumor of mesothelium"," malignant tumor of the mesothelium"," malignant tumour of mesothelium"," malignant tumour of the mesothelium"," mesom"," mesothelioma (malignant, clinical disorder)"," mesothelioma, somatic"," pleural mesothelioma"]}