{"Name":"Monoclonal gammopathy of undetermined significance","DiseaseID__c":"GARD:0007034","id":7034,"encodedName":"monoclonal-gammopathy-of-undetermined-significance","IsDeleted":false,"Disease_Name_Full__c":"Monoclonal gammopathy of undetermined significance","Xref_IDs__c":"277577000; 35601003; 58648008; C0026470; C3996; D008998; DOID:7442; MEDGEN:44485; MONDO:0004225","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":2,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0004225","Disease_Description__c":"A condition characterized by the presence of a monoclonal gammopathy (MG) in which the clonal mass has not reached a predefined state in which the condition is considered malignant. Up to 25% of cases of monoclonal gammopathy of undetermined significance (MGUS) progress to a B-cell malignancy or myeloma. MGUS may occur in conjunction with various carcinomas, chronic inflammatory and infectious conditions, and other diseases.","GARD_Name__c":"Monoclonal gammopathy of undetermined significance","GARD_Synonym__c":"asymptomatic monoclonal gammopathy; benign monoclonal gammopathy; mgus; mgus - monoclonal gammopathy of uncertain significance; mgus - monoclonal gammopathy of undetermined significance; monoclonal gammopathy of uncertain significance; monoclonal gammopathy of undetermined significance (mgus); monoclonal gammopathy of undetermined significance (morphologic abnormality); monoclonal gammopathy of unknown significance; monoclonal gammopathy, benign","Curated_Disease_Description_Source__c":"GARD:0007034","Curated_Disease_Description__c":"Monoclonal gammopathy of undetermined significance (MGUS) is a condition in which an abnormal protein called monoclonal protein is detected in the blood. MGUS typically does not cause any problems, although some affected people may experience numbness, tingling or weakness. In some cases, MGUS may progress over time to certain forms of blood cancer (such as multiple myeloma, macroglobulinemia, or B-cell lymphoma). MGUS is thought to be a multifactorial condition that is likely associated with the effects of multiple genes in combination with lifestyle and environmental factors. People with MGUS are usually monitored closely to ensure that the levels of monoclonal protein do not rise and other problems do not develop.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0004225","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Monoclonal gammopathy of undetermined significance (MGUS) is a condition in which an abnormal protein called monoclonal protein is detected in the blood. MGUS typically does not cause any problems, although some affected people may experience numbness, tingling or weakness. In some cases, MGUS may progress over time to certain forms of blood cancer (such as multiple myeloma, macroglobulinemia, or B-cell lymphoma). MGUS is thought to be a multifactorial condition that is likely associated with the effects of multiple genes in combination with lifestyle and environmental factors. People with MGUS are usually monitored closely to ensure that the levels of monoclonal protein do not rise and other problems do not develop.","Curated_Disease_Description_Source__c":"GARD:0007034","GARD_Synonym__c":"asymptomatic monoclonal gammopathy; benign monoclonal gammopathy; mgus; mgus - monoclonal gammopathy of uncertain significance; mgus - monoclonal gammopathy of undetermined significance; monoclonal gammopathy of uncertain significance; monoclonal gammopathy of undetermined significance (mgus); monoclonal gammopathy of undetermined significance (morphologic abnormality); monoclonal gammopathy of unknown significance; monoclonal gammopathy, benign","Name":"Monoclonal gammopathy of undetermined significance","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"HealthTree Foundation","Website__c":"https://healthtree.org/"},{"Account_Name__c":"Alianza Iberoamericana de Enfermedades Raras o Poco Frecuentes","Website__c":"https://aliber.org/web/"},{"Account_Name__c":"Federación Mexicana de Enfermedades Raras (FEMEXER)","Website__c":"http://www.femexer.org/"},{"Account_Name__c":"Federación Española de Enfermedades Raras","Website__c":"https://enfermedades-raras.org/"},{"Account_Name__c":"Federación Colombiana de Enfermedades Raras","Website__c":"http://www.fecoer.org"},{"Account_Name__c":"Federación Argentina de Enfermedades Poco Frecuentes","Website__c":"https://fadepof.org.ar/"},{"Account_Name__c":"Asociación Todos Unidos Enfermedades Raras Uruguay","Website__c":"https://atueru.org.uy/"},{"Account_Name__c":"International Myeloma Foundation","Website__c":"https://www.myeloma.org/"}],"External_Identifier_Disease__c":[{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=277577000","Source__c":"C0026470; MONDO:0004225","Xref__c":"277577000"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=58648008","Source__c":"C0026470; MONDO:0004225","Xref__c":"58648008"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3996","Source__c":"C0026470; MONDO:0004225","Xref__c":"C3996"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A7442","Source__c":"MONDO:0004225","Xref__c":"DOID:7442"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0026470","Source__c":"C0026470","Xref__c":"C0026470"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C008998","Source__c":"C0026470; MONDO:0004225","Xref__c":"D008998"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=44485","Source__c":"C0026470","Xref__c":"MEDGEN:44485"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0004225","Source__c":"GARD:0007034","Xref__c":"MONDO:0004225"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=35601003","Source__c":"C0026470","Xref__c":"35601003"}],"tags":{},"synonyms":["asymptomatic monoclonal gammopathy"," benign monoclonal gammopathy"," mgus"," mgus - monoclonal gammopathy of uncertain significance"," mgus - monoclonal gammopathy of undetermined significance"," monoclonal gammopathy of uncertain significance"," monoclonal gammopathy of undetermined significance (mgus)"," monoclonal gammopathy of undetermined significance (morphologic abnormality)"," monoclonal gammopathy of unknown significance"," monoclonal gammopathy, benign"],"spanishId":12572,"spanishName":"gamapatia-monoclonal-de-significado-incierto"}