{"Name":"Ocular melanoma","DiseaseID__c":"GARD:0007236","id":7236,"encodedName":"ocular-melanoma","IsDeleted":false,"Disease_Name_Full__c":"Ocular melanoma","Xref_IDs__c":"C0558356; C8562; DOID:1752; MEDGEN:107846; MONDO:0006325","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":1,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":1,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":2,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0006325","Disease_Description__c":"A melanoma that arises from the structures of the eye or ocular adnexa.","GARD_Name__c":"Ocular melanoma","GARD_Synonym__c":"eye melanoma; eye melanoma (disease); eyeball of camera-type eye melanoma; eyeball of camera-type eye melanoma (disease); malignant melanoma of eye; melanoma (disease) of eyeball of camera-type eye; melanoma of eye; melanoma of the eye; mm (malignant melanoma) of eye","Curated_Disease_Description_Source__c":"GARD:0007236","Curated_Disease_Description__c":"Ocular melanoma (OM) is a cancer in pigment-producing cells of the eye called melanocytes. Melanocytes are cells that produce the pigment melanin that colors the skin, hair, and eyes, as well as forms moles. There are four tissues in the eye in which melanoma can develop: the uveal tract (uvea); conjunctiva; eyelid; and orbit. The uvea - the middle layer within the eye - is divided into three main parts: the iris, ciliary body, and choroid. Uveal melanoma, also called intraOcular melanoma, is the most common Ocular melanoma. Conjunctival melanoma manifests on the surface of the eye and has been increasing in incidence. Eyelid and primary orbital melanoma are the least common variants.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0006325","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Ocular melanoma (OM) is a cancer in pigment-producing cells of the eye called melanocytes. Melanocytes are cells that produce the pigment melanin that colors the skin, hair, and eyes, as well as forms moles. There are four tissues in the eye in which melanoma can develop: the uveal tract (uvea); conjunctiva; eyelid; and orbit. The uvea - the middle layer within the eye - is divided into three main parts: the iris, ciliary body, and choroid. Uveal melanoma, also called intraOcular melanoma, is the most common Ocular melanoma. Conjunctival melanoma manifests on the surface of the eye and has been increasing in incidence. Eyelid and primary orbital melanoma are the least common variants.","Curated_Disease_Description_Source__c":"GARD:0007236","GARD_Synonym__c":"eye melanoma; eye melanoma (disease); eyeball of camera-type eye melanoma; eyeball of camera-type eye melanoma (disease); malignant melanoma of eye; melanoma (disease) of eyeball of camera-type eye; melanoma of eye; melanoma of the eye; mm (malignant melanoma) of eye","Name":"Ocular melanoma","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Melanoma Research Foundation","Website__c":"https://www.melanoma.org/"},{"Account_Name__c":"EYEMELANOMA.ORG","Website__c":"https://eyemelanoma.org/"},{"Account_Name__c":"Ocular Melanoma Foundation","Website__c":"https://ocularmelanoma.org/"},{"Account_Name__c":"A Cure In Sight","Website__c":"https://acureinsight.org/"},{"Account_Name__c":"Melanoma Research Alliance","Website__c":"https://www.curemelanoma.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A1752","Source__c":"MONDO:0006325","Xref__c":"DOID:1752"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C8562","Source__c":"C0558356; MONDO:0006325","Xref__c":"C8562"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0558356","Source__c":"C0558356","Xref__c":"C0558356"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=107846","Source__c":"C0558356","Xref__c":"MEDGEN:107846"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0006325","Source__c":"GARD:0007236","Xref__c":"MONDO:0006325"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=274087000","Source__c":"C0558356","Xref__c":"274087000"},{"URL__c":"https://melanoma.org/wp-content/uploads/2020/05/Final-High-Level-Summary-FDA-OM-Listening-Session.pdf"}],"tags":{"Disease Category":["Cancer"]},"synonyms":["eye melanoma"," eye melanoma (disease)"," eyeball of camera-type eye melanoma"," eyeball of camera-type eye melanoma (disease)"," malignant melanoma of eye"," melanoma (disease) of eyeball of camera-type eye"," melanoma of eye"," melanoma of the eye"," mm (malignant melanoma) of eye"]}