{"Name":"Paget disease of the nipple","DiseaseID__c":"GARD:0007303","id":7303,"encodedName":"paget-disease-of-the-nipple","IsDeleted":false,"Disease_Name_Full__c":"Paget disease of the nipple","Xref_IDs__c":"403946000; C1704323; C3301; MEDGEN:352830; MONDO:0015873; ORPHA:180275","USA_Estimate__c":"5,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"8,000 to 80,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":1,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0015873","Disease_Description__c":"Paget disease of the nipple describes a rare presentation of breast cancer, seen most frequently in women aged 50-60, manifesting with nipple drainage and itching, erythema, crusty and excoriated nipple, thickened plaques, and hyperpigmentation (less frequently). It is due to tumor cells invading the nipple-areola complex and represents 1-3% of all new breast cancer diagnoses.","GARD_Name__c":"Paget disease of the nipple","GARD_Synonym__c":"mammary paget disease; nipple paget's disease; paget disease of nipple; paget disease of the breast; paget's disease of nipple; paget's disease of the breast; paget's disease of the nipple","Curated_Disease_Description_Source__c":"MONDO:0015873","Curated_Disease_Description__c":"Paget disease of the nipple describes a rare presentation of breast cancer, seen most frequently in women aged 50-60, manifesting with nipple drainage and itching, erythema, crusty and excoriated nipple, thickened plaques, and hyperpigmentation (less frequently). It is due to tumor cells invading the nipple-areola complex and represents 1-3% of all new breast cancer diagnoses.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"5,000","Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:180275","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0015873","ORPHANET_ID__c":"ORPHA:180275","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Enfermedad de paget del pezón","Spanish_Description_Source__c":"ORPHA:180275","Spanish_Description__c":"La enfermedad de Paget del pezón describe una presentación rara del cáncer de mama, visto con mayor frecuencia en mujeres de 50-60 años de edad, que se manifiesta con secreción del pezón y picazón, eritema, costras, pezón excoriado, placas engrosadas e hiperpigmentación (con menos frecuencia). Es debida a la presencia de células tumorales que invaden el complejo areola-pezón y representa entre 1-3% de todos los cánceres de mama diagnosticados.","Spanish_Disease_Name__c":"enfermedad de paget del pezón","Spanish_GARD_Synonym__c":"enfermedad de paget del pecho; enfermedad de paget mamaria","Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Paget disease of the nipple describes a rare presentation of breast cancer, seen most frequently in women aged 50-60, manifesting with nipple drainage and itching, erythema, crusty and excoriated nipple, thickened plaques, and hyperpigmentation (less frequently). It is due to tumor cells invading the nipple-areola complex and represents 1-3% of all new breast cancer diagnoses.","Curated_Disease_Description_Source__c":"MONDO:0015873","GARD_Synonym__c":"mammary paget disease; nipple paget's disease; paget disease of nipple; paget disease of the breast; paget's disease of nipple; paget's disease of the breast; paget's disease of the nipple","Name":"Paget disease of the nipple","Curated_USA_Estimate__c":"5,000","estimateUsa":"5,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Breastcancer.org","Website__c":"https://www.breastcancer.org/"},{"Account_Name__c":"Young Survival Coalition","Website__c":"https://youngsurvival.org/"},{"Account_Name__c":"CancerCare","Website__c":"https://www.cancercare.org/"},{"Account_Name__c":"Susan G. Komen","Website__c":"https://www.komen.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Urogenital Disorders","Tag_Category__c":"Disease Category","category_description":"Urinary and reproductive diseases affect the kidneys, ureters, bladder, urethra, or the reproductive organs.","curated_tag_name":"Urinary and reproductive diseases"},{"Tag_Name__c":"Obstetrics / Gynecology","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:180275"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C1704323","Source__c":"C1704323","Xref__c":"C1704323"},{"URL__c":"https://www.orpha.net/en/disease/detail/180275","Source__c":"C1704323; MONDO:0015873; ORPHA:180275","Xref__c":"ORPHA:180275"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=352830","Source__c":"C1704323","Xref__c":"MEDGEN:352830"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3301","Source__c":"C1704323; MONDO:0015873","Xref__c":"C3301"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=403946000","Source__c":"C1704323; MONDO:0015873","Xref__c":"403946000"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0015873","Source__c":"GARD:0007303","Xref__c":"MONDO:0015873"}],"tags":{"Specialist":["Cancer - Oncologist","Obstetrics / Gynecology"],"Disease Category":["Cancer","Urogenital Disorders"]},"synonyms":["mammary paget disease"," nipple paget's disease"," paget disease of nipple"," paget disease of the breast"," paget's disease of nipple"," paget's disease of the breast"," paget's disease of the nipple"]}