{"Name":"PANDAS","DiseaseID__c":"GARD:0007312","id":7312,"encodedName":"pandas","IsDeleted":false,"Disease_Name_Full__c":"PANDAS","Xref_IDs__c":"C2931429; C537163; MEDGEN:419798; MONDO:0019020; ORPHA:66624","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0019020","Disease_Description__c":"PANDAS is an acronym for Pediatric Autoimmune Neuropsychiatric Disorders Associated with a group A beta-hemolytic Streptococcal infection and applied to a subgroup of children with obsessive-compulsive disorder (OCD) and/or tic disorders.","GARD_Name__c":"PANDAS","GARD_Synonym__c":"paediatric autoimmune disorders associated with streptococcus infections; paediatric autoimmune neuropsychiatric disorders associated with streptococcus infections; pandas - pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection; pediatric autoimmune disorders associated with streptococcus infections; pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection; pediatric autoimmune neuropsychiatric disorders associated with streptococcus infections","Curated_Disease_Description_Source__c":"GARD:0007312","Curated_Disease_Description__c":"Pediatric autoimmune neuropsychiatric disorders associated with Streptococcus infections (PANDAS) is a neurological and psychiatric condition in which symptoms are brought on or worsened by a Streptococcal (strep) infection. PANDAS is a subtype of pediatric acute-onset neuropsychiatric syndrome (PANS). The main neuropsyciatric symptoms are the presence of obsessive-compulsive disorder (OCD) and/or tics (uncontrolled, sudden, repetitive movements or sounds), which are severe enough to interfere the ability to function. After the initial strep infection, subsequent flares can be associated with other infectious or environmental triggers. The underlying cause of PANDAS is unclear, but studies suggest that a strep infection causes an abnormal immune response resulting in neuropsychiatric symptoms.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"as a Child","SourceID__c":"ORPHA:66624","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0019020","ORPHANET_ID__c":"ORPHA:66624","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Pandas","Spanish_Description_Source__c":"ORPHA:66624","Spanish_Description__c":"El acrónimo PANDAS (en inglés Pediatric Autoimmune Neuropsychiatric Disorders Associated with a group A beta-hemolytic streptococcal infection) se aplica a un subgrupo de niños con trastorno obsesivo-compulsivo (TOC) y/o tics.","Spanish_Disease_Name__c":"pandas","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:98006","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Pediatric autoimmune neuropsychiatric disorders associated with Streptococcus infections (PANDAS) is a neurological and psychiatric condition in which symptoms are brought on or worsened by a Streptococcal (strep) infection. PANDAS is a subtype of pediatric acute-onset neuropsychiatric syndrome (PANS). The main neuropsyciatric symptoms are the presence of obsessive-compulsive disorder (OCD) and/or tics (uncontrolled, sudden, repetitive movements or sounds), which are severe enough to interfere the ability to function. After the initial strep infection, subsequent flares can be associated with other infectious or environmental triggers. The underlying cause of PANDAS is unclear, but studies suggest that a strep infection causes an abnormal immune response resulting in neuropsychiatric symptoms.","Curated_Disease_Description_Source__c":"GARD:0007312","GARD_Synonym__c":"paediatric autoimmune disorders associated with streptococcus infections; paediatric autoimmune neuropsychiatric disorders associated with streptococcus infections; pandas - pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection; pediatric autoimmune disorders associated with streptococcus infections; pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection; pediatric autoimmune neuropsychiatric disorders associated with streptococcus infections","Name":"PANDAS","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"PACE Foundation","Website__c":"https://pacefoundation4kids.org/"},{"Account_Name__c":"Autoimmune Registry","Website__c":"https://www.autoimmuneregistry.org/"},{"Account_Name__c":"EXPAND","Website__c":"https://expand.care/"},{"Account_Name__c":"Allergy & Asthma Network Mothers of Asthmatics","Website__c":"https://allergyasthmanetwork.org/"},{"Account_Name__c":"Autoimmune Association","Website__c":"https://autoimmune.org/"},{"Account_Name__c":"International OCD Foundation","Website__c":"https://iocdf.org/"},{"Account_Name__c":"PANDAS Network","Website__c":"https://pandasnetwork.org/"},{"Account_Name__c":"PANS Research Consortium","Website__c":"https://med.stanford.edu/pans/research/PANS-consortium.html"},{"Account_Name__c":"PANDAS Physicians Network","Website__c":"https://www.pandasppn.org/parent-information/"},{"Account_Name__c":"Pediatric Research and Advocacy Initiative","Website__c":"https://praikids.org/"},{"Account_Name__c":"ASPIRE","Website__c":"https://aspire.care/"},{"Account_Name__c":"PANS PANDAS UK","Website__c":"https://www.panspandasuk.org"},{"Account_Name__c":"Northwest PANDAS/PANS Network","Website__c":"https://www.nwppn.org/"},{"Account_Name__c":"Neuroimmune Foundation","Website__c":"https://www.neuroimmune.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Neurology","Tag_Category__c":"Disease Category;Specialist","category_description":"Neurological diseases affect the brain, spinal cord, cranial nerves, autonomic nerves, or other peripheral nerves.","curated_tag_name":"Neurological diseases"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Childhood","Provided_By__c":"ORPHA:66624"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=419798","Source__c":"C2931429","Xref__c":"MEDGEN:419798"},{"URL__c":"https://www.orpha.net/en/disease/detail/66624","Source__c":"C2931429; MONDO:0019020; ORPHA:66624","Xref__c":"ORPHA:66624"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C537163","Source__c":"MONDO:0019020","Xref__c":"C537163"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C2931429","Source__c":"C2931429","Xref__c":"C2931429"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=446682003","Source__c":"C2931429","Xref__c":"446682003"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0019020","Source__c":"GARD:0007312","Xref__c":"MONDO:0019020"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Loss of developmental skills, as manifested by loss of developmental milestones.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002376","HPO_Synonym__c":"Loss of acquired milestones; Loss of developmental milestones; Loss of milestones; Mental deterioration in childhood; Neurodevelopmental regression; Psychomotor regression; Psychomotor regression beginning in infancy; Psychomotor regression in infants; Psychomotor regression, progressive","HPO_Name__c":"Developmental regression","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Lack of the ability to control the urinary bladder leading to involuntary urination at an age where control of the bladder should already be possible.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000805","HPO_Name__c":"Enuresis","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An abnormally heightened sensitivity to loud sounds.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002183","HPO_Synonym__c":"Fear of loud sounds","HPO_Name__c":"Phonophobia","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A type of anxiety disorder characterized by the avoidance of public places, especially where crowds gather.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000756","HPO_Synonym__c":"Fear of open spaces","HPO_Name__c":"Agoraphobia","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An abnormal shift in patterns of thinking, acting, or feeling.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000751","HPO_Synonym__c":"Personality change; Personality changes","HPO_Name__c":"Personality changes","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Repeated, individually recognizable, intermittent movements or movement fragments that are almost always briefly suppressible and are usually associated with awareness of an urge to perform the movement.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100033","HPO_Synonym__c":"Tic disorder","HPO_Name__c":"Tics","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Joint pain.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002829","HPO_Synonym__c":"Arthralgias; Joint pain","HPO_Name__c":"Arthralgia","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Fears of rejection by and/or separation from significant others are associated with fears of excessive dependency and complete loss of autonomy.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0031468","HPO_Name__c":"Separation insecurity","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Attention deficit hyperactivity disorder (ADHD) manifests at age 2-3 years or by first grade at the latest. The main symptoms are distractibility, impulsivity, hyperactivity, and often trouble organizing tasks and projects, difficulty going to sleep, and social problems from being aggressive, loud, or impatient.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0007018","HPO_Synonym__c":"ADHD; Attention deficit; Attention deficit disorder; Attention deficit-hyperactivity disorder; Attention deficits; Childhood attention deficit/hyperactivity disorder","HPO_Name__c":"Attention deficit hyperactivity disorder","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Acting on the spur of the moment or on a momentary basis without consideration of outcomes; having difficulty establishing or following plans; experiencing a sense of urgency and engaging in behavior that is uninhibited, cannot be inhibited, and is uncontrolled. The possibility of repression is inconceivable.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100710","HPO_Synonym__c":"Impulsive; Impulsivity","HPO_Name__c":"Impulsivity","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"The presence of one or more obsessive-compulsive personality traits. Obsessions refer to persistent intrusive thoughts, and compulsions to intrusive behaviors, which the affected person experiences as involuntary, senseless, or repugnant.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0008770","HPO_Synonym__c":"Obsessive-compulsive trait; Obsessive-compulsive traits","HPO_Name__c":"Obsessive-compulsive trait","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Excluded (0%)","Feature__r":{"HPO_Description__c":"A state of abnormally elevated or irritable mood, arousal, and/or energy levels.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100754","HPO_Synonym__c":"Hypomania; Hypomanic; Manic","HPO_Name__c":"Mania","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Chorea (Greek for 'dance') refers to widespread arrhythmic involuntary movements of a forcible, jerky and restless fashion. It is a random-appearing sequence of one or more discrete involuntary movements or movement fragments. Movements appear random because of variability in timing, duration or location. Each movement may have a distinct start and end. However, movements may be strung together and thus may appear to flow randomly from one muscle group to another. Chorea can involve the trunk, neck, face, tongue, and extremities.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002072","HPO_Synonym__c":"Choreic movements; Choreiform movements","HPO_Name__c":"Chorea","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0040183","HPO_Synonym__c":"Stool holding; Stool soiling","HPO_Name__c":"Encopresis","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An abnormal fear-induced behavior includes observable actions. This behavior is characterized by abnormal responses to fear or abnormal fear levels. Examples of such behavior include avoiding fear-inducing situations.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100852","HPO_Synonym__c":"Abnormal fear-induced behavior; Abnormal fear/anxiety-related behavior","HPO_Name__c":"Abnormal fear-induced behavior","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Increased susceptibility to streptococcus pneumoniae infections as manifested by a history of recurrent infections by streptococcus pneumoniae.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0005366","HPO_Name__c":"Recurrent streptococcus pneumoniae infections","Feature_System__c":"Respiratory system; Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An abnormal fear of being in a closed or narrow space with no escape is called claustrophobia.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0025253","HPO_Name__c":"Claustrophobia","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Frequently experiencing feelings of being down, miserable, and/or hopeless; struggling to recover from these moods; having a pessimistic outlook on the future; feeling a pervasive sense of shame; having a low self-worth; experiencing thoughts of suicide and engaging in suicidal behavior.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000716","HPO_Synonym__c":"Depression; Depressive episode; Depressivity","HPO_Name__c":"Depression","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An emotional state characterized by negative feelings of heightened frustration, annoyance, or feeling upset, often triggered by internal factors (e.g., fatigue, hunger, unfulfilled desires) or external factors (e.g., social or environmental challenges). Irritability may be unpredictable, and is accompanied by a lowered threshold for emotional reactivity and observable features (speech, facial expressions, or psychomotor activity).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000737","HPO_Synonym__c":"Cranky; Easily annoyed; Easily bothered; Easily upset; Grumpy; Hot-temper; Irritability; Irritable; Irritable mood; On edge; Quick-temper; Short fuse; Short tempered","HPO_Name__c":"Irritability","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Lack of physical coordination resulting in an abnormal tendency to drop items or bump into objects.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002312","HPO_Synonym__c":"Clumsiness","HPO_Name__c":"Clumsiness","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Unstable emotional experiences and frequent mood changes; emotions that are easily aroused, intense, and/or disproportionate to events and circumstances.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000712","HPO_Name__c":"Emotional lability","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An enduring pattern of uncooperative, defiant, and hostile behavior towards authority figures that does not involve major antisocial violations, is not accounted for by the child's developmental stage, and results in significant functional impairment. A certain level of oppositional behavior is common in children and adolescents.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0010865","HPO_Synonym__c":"ODD","HPO_Name__c":"Oppositional defiant disorder","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An abnormal pattern in the quality, quantity, or characteristics of sleep.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002360","HPO_Synonym__c":"Difficulty sleeping; Sleep abnormality; Sleep disturbances; Sleep dysfunction; Sleep-wake disturbance; Trouble sleeping","HPO_Name__c":"Sleep disturbance","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66624","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Lack of desire to eat (loss of appetite).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002039","HPO_Synonym__c":"Anorexia; Deliberately not eating; Obsessive dieting; Refusing to eat","HPO_Name__c":"Anorexia","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Disease Category":["Neurology"],"Specialist":["Neurology","Pediatrics"]},"synonyms":["paediatric autoimmune disorders associated with streptococcus infections"," paediatric autoimmune neuropsychiatric disorders associated with streptococcus infections"," pandas - pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection"," pediatric autoimmune disorders associated with streptococcus infections"," pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection"," pediatric autoimmune neuropsychiatric disorders associated with streptococcus infections"]}