{"Name":"Placental site trophoblastic tumor","DiseaseID__c":"GARD:0007403","id":7403,"encodedName":"placental-site-trophoblastic-tumor","IsDeleted":false,"Disease_Name_Full__c":"Placental site trophoblastic tumor","Xref_IDs__c":"237252008; 75320001; C0206666; C3757; D018245; DOID:3596; MEDGEN:104914; MONDO:0020552; ORPHA:99928","USA_Estimate__c":"1,000","No_of_Specialist_Tagsa__c":4,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"1 to 8,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":6,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0020552","Disease_Description__c":"A rare gestational trophoblastic neoplasm characterized histologically by invasion of myometrium by intermediate trophoblastic cells without chorionic villi and containing human placental lactogen hormone (hPL). Tissue necrosis is usually absent and hemorrhage is mild. The tumor develops from the placental implantation site and always occurs following pregnancy, voluntary termination of pregnancy (VTP) or miscarriage. Indicative signs are irregular metrorrhagia some time after spontaneous miscarriage or VTP, presence of metastasis or unexplained metrorrhagia in the weeks and months following normal childbirth or ectopic pregnancy.","GARD_Name__c":"Placental site trophoblastic tumor","GARD_Synonym__c":"placental site gestational trophoblastic tumor; placental site gestational trophoblastic tumour; placental site trophoblastic tumor (morphologic abnormality); placental site trophoblastic tumour (morphologic abnormality); placental-site gestational trophoblastic neoplasm; placental-site gestational trophoblastic tumor; placental-site gestational trophoblastic tumour; placental-site gtt; psst","Curated_Disease_Description_Source__c":"PlainLanguagePilotV1-Sep23","Curated_Disease_Description__c":"Placental site trophoblastic tumor is a rare type of cancer that can happen after a pregnancy, miscarriage, or termination. It starts in the place where the placenta was attached to the uterus. This tumor is made up of cells that produce a hormone called human placental lactogen (hPL). Unlike other types of tumors, this one usually does not cause tissue death and bleeding is not severe.\nSymptoms include irregular bleeding after a miscarriage or termination, or unexplained bleeding after a normal delivery or ectopic pregnancy. In some cases, the cancer may spread to other parts of the body.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"1,000","Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:99928","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0020552","ORPHANET_ID__c":"ORPHA:99928","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Tumor trofoblástico del sitio placentario","Spanish_Description_Source__c":"ORPHA:99928","Spanish_Description__c":"Es una neoplasia trofoblástica gestacional poco frecuente caracterizada histológicamente por la invasión del miometrio por células trofoblásticas intermedias sin vellosidades coriónicas y que contienen el lactógeno placentari humano (hPL). La necrosis tisular suele estar ausente y la hemorragia es leve. El tumor se desarrolla a partir del lugar de implantación de la placenta y siempre se produce tras un embarazo, una interrupción voluntaria del embarazo (IVE) o un aborto espontáneo. Los signos indicativos son la metrorragia irregular algún tiempo después de un aborto espontáneo o IVE, la presencia de metástasis o la metrorragia inexplicable en las semanas y meses siguientes al parto normal o al embarazo ectópico.","Spanish_Disease_Name__c":"tumor trofoblástico del sitio placentario","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Placental site trophoblastic tumor is a rare type of cancer that can happen after a pregnancy, miscarriage, or termination. It starts in the place where the placenta was attached to the uterus. This tumor is made up of cells that produce a hormone called human placental lactogen (hPL). Unlike other types of tumors, this one usually does not cause tissue death and bleeding is not severe.\nSymptoms include irregular bleeding after a miscarriage or termination, or unexplained bleeding after a normal delivery or ectopic pregnancy. In some cases, the cancer may spread to other parts of the body.","Curated_Disease_Description_Source__c":"PlainLanguagePilotV1-Sep23","GARD_Synonym__c":"placental site gestational trophoblastic tumor; placental site gestational trophoblastic tumour; placental site trophoblastic tumor (morphologic abnormality); placental site trophoblastic tumour (morphologic abnormality); placental-site gestational trophoblastic neoplasm; placental-site gestational trophoblastic tumor; placental-site gestational trophoblastic tumour; placental-site gtt; psst","Name":"Placental site trophoblastic tumor","Curated_USA_Estimate__c":"1,000","estimateUsa":"1,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"American Cancer Society","Website__c":"https://www.cancer.org"},{"Account_Name__c":"Cancer.net","Website__c":"https://www.cancer.net/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Urogenital Disorders","Tag_Category__c":"Disease Category","category_description":"Urinary and reproductive diseases affect the kidneys, ureters, bladder, urethra, or the reproductive organs.","curated_tag_name":"Urinary and reproductive diseases"},{"Tag_Name__c":"Obstetrics / Gynecology","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Rare gynecological tumor","Tag_Category__c":"Account;Specialist","curated_tag_name":"Gynecological tumors"},{"Tag_Name__c":"Pregnancy-Related Diseases","Tag_Category__c":"Specialist","curated_tag_name":"Pregnancy-related diseases"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:99928"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C018245","Source__c":"C0206666; MONDO:0020552","Xref__c":"D018245"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A3596","Source__c":"MONDO:0020552","Xref__c":"DOID:3596"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=237252008","Source__c":"C0206666; MONDO:0020552","Xref__c":"237252008"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0206666","Source__c":"C0206666","Xref__c":"C0206666"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3757","Source__c":"C0206666; MONDO:0020552","Xref__c":"C3757"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=104914","Source__c":"C0206666","Xref__c":"MEDGEN:104914"},{"URL__c":"https://www.orpha.net/en/disease/detail/99928","Source__c":"C0206666; MONDO:0020552; ORPHA:99928","Xref__c":"ORPHA:99928"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=75320001","Source__c":"C0206666","Xref__c":"75320001"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0020552","Source__c":"GARD:0007403","Xref__c":"MONDO:0020552"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:99928","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Bleeding at irregular intervals.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100608","HPO_Synonym__c":"Abnormal uterus bleeding; Intermenstrual bleeding; Menstrual spotting","HPO_Name__c":"Metrorrhagia","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:99928","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Absence of menses for an interval of time equivalent to a total of more than (or equal to) 3 previous cycles or 6 months.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000141","HPO_Synonym__c":"Abnormal absence of menstruation","HPO_Name__c":"Amenorrhea","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Specialist":["Cancer - Oncologist","Obstetrics / Gynecology","Rare gynecological tumor","Pregnancy-Related Diseases"],"Disease Category":["Cancer","Urogenital Disorders"],"Account":["Rare gynecological tumor"]},"synonyms":["placental site gestational trophoblastic tumor"," placental site gestational trophoblastic tumour"," placental site trophoblastic tumor (morphologic abnormality)"," placental site trophoblastic tumour (morphologic abnormality)"," placental-site gestational trophoblastic neoplasm"," placental-site gestational trophoblastic tumor"," placental-site gestational trophoblastic tumour"," placental-site gtt"," psst"]}