{"Name":"Eccrine porocarcinoma","DiseaseID__c":"GARD:0007431","id":7431,"encodedName":"eccrine-porocarcinoma","IsDeleted":false,"Disease_Name_Full__c":"Eccrine porocarcinoma","Xref_IDs__c":"128685001; 254708001; C1266065; C5560; D057090; DOID:7566; MEDGEN:266098; MONDO:0006189","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":1,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0006189","Disease_Description__c":"A carcinoma with eccrine differentiation arising from the sweat glands. It may arise de novo or as a malignant transformation of a pre-existing poroma. It usually grows in the legs, buttocks, feet, and trunk and usually presents as an ulcerative plaque. It is characterized by the presence of intraepidermal and dermal nests of malignant epithelial cells. It may recur after excision and metastasize to the lymph nodes and less frequently to distal anatomic sites.","GARD_Name__c":"Eccrine porocarcinoma","GARD_Synonym__c":"eccrine porocarcinoma of skin; eccrine poroma, malignant; epidermotropic eccrine carcinoma; malignant eccrine poroma; porocarcinoma","Curated_Disease_Description_Source__c":"GARD:0007431","Curated_Disease_Description__c":"Eccrine porocarcinoma is a rare type of skin cancer that may occur by chance or may develop from a benign (non-cancerous) skin tumor. They affect the eccrine sweat glands, which are the major sweat glands of the body. Eccrine porocarcinoma usually are found in adults older than 60 and appear as a single red elevated solid mass (nodule) or a thickened or elevated lesion (plaque). They are found anywhere on the body, but occur most commonly on the lower limbs, head, and upper limbs. Most people with an Eccrine porocarcinoma do not have symptoms; however some individuals may notice bleeding from the tumor or itching. Factors that may increase the risk to develop an Eccrine porocarcinoma include family history, suppression of the immune system, and exposure to ultraviolet light or radiation.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0006189","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Eccrine porocarcinoma is a rare type of skin cancer that may occur by chance or may develop from a benign (non-cancerous) skin tumor. They affect the eccrine sweat glands, which are the major sweat glands of the body. Eccrine porocarcinoma usually are found in adults older than 60 and appear as a single red elevated solid mass (nodule) or a thickened or elevated lesion (plaque). They are found anywhere on the body, but occur most commonly on the lower limbs, head, and upper limbs. Most people with an Eccrine porocarcinoma do not have symptoms; however some individuals may notice bleeding from the tumor or itching. Factors that may increase the risk to develop an Eccrine porocarcinoma include family history, suppression of the immune system, and exposure to ultraviolet light or radiation.","Curated_Disease_Description_Source__c":"GARD:0007431","GARD_Synonym__c":"eccrine porocarcinoma of skin; eccrine poroma, malignant; epidermotropic eccrine carcinoma; malignant eccrine poroma; porocarcinoma","Name":"Eccrine porocarcinoma","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A7566","Source__c":"MONDO:0006189","Xref__c":"DOID:7566"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C1266065","Source__c":"C1266065","Xref__c":"C1266065"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=266098","Source__c":"C1266065","Xref__c":"MEDGEN:266098"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C057090","Source__c":"C1266065; MONDO:0006189","Xref__c":"D057090"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C5560","Source__c":"C1266065; MONDO:0006189","Xref__c":"C5560"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=254708001","Source__c":"C1266065; MONDO:0006189","Xref__c":"254708001"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0006189","Source__c":"GARD:0007431","Xref__c":"MONDO:0006189"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=128685001","Source__c":"C1266065","Xref__c":"128685001"}],"tags":{"Disease Category":["Cancer"]},"synonyms":["eccrine porocarcinoma of skin"," eccrine poroma, malignant"," epidermotropic eccrine carcinoma"," malignant eccrine poroma"," porocarcinoma"]}