{"Name":"Prinzmetal angina","DiseaseID__c":"GARD:0007465","id":7465,"encodedName":"prinzmetal-angina","IsDeleted":false,"Disease_Name_Full__c":"Prinzmetal angina","Xref_IDs__c":"87343002; C0002963; C66915; D000788; DOID:0111151; MEDGEN:295; MONDO:0006021","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":1,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":3,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0006021","Disease_Description__c":"A syndrome typically consisting of angina (cardiac chest pain) at rest that occurs in cycles. It is caused by vasospasm, a narrowing of the coronary arteries caused by contraction of the smooth muscle tissue in the vessel walls rather than directly by atherosclerosis (buildup of fatty plaque and hardening of the arteries). For a portion of patients Prinzmetal's angina may be a manifestation of vasospastic disorder and is associated with migraine, Raynaud's phenomenon or aspirin-induced asthma.","GARD_Name__c":"Prinzmetal angina","GARD_Synonym__c":"angina inversa; angina pectoris, variant; coronary artery spasm angina; prinzmetal's angina; prinzmetal's variant angina; variant angina; variant angina pectoris","Curated_Disease_Description_Source__c":"GARD:0007465","Curated_Disease_Description__c":"Prinzmetal's variant angina (PVA) is characterized by recurrent episodes of chest pain (angina) that usually occur when a person is at rest, between midnight and early morning. Typical angina, by contrast, is often triggered by physical exertion or emotional stress. Episodes of PVA can be very painful, and may last from several minutes to thirty minutes. In some cases the pain may spread from the chest to the head, shoulder, or arm. The pain associated with PVA is caused by a spasm in the arteries that supply blood to the heart muscle (coronary arteries). This results in an obstruction of blood flow. In some people, persistent spasms increase the risk for serious complications such as a life-threatening arrhythmia or heart attack. PVA most commonly occurs in people who smoke and people who have high cholesterol or high blood pressure. In many cases it occurs for unknown reasons in otherwise healthy people. In some cases it may be triggered by alcohol withdrawal, stress, exposure to cold, certain medications, or use of stimulants such as cocaine. The diagnosis of PVA involves findings on an electrocardiogram, evidence of the spasms on angiogram, and relief of sudden symptoms with medicines called nitrates.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0006021","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Prinzmetal's variant angina (PVA) is characterized by recurrent episodes of chest pain (angina) that usually occur when a person is at rest, between midnight and early morning. Typical angina, by contrast, is often triggered by physical exertion or emotional stress. Episodes of PVA can be very painful, and may last from several minutes to thirty minutes. In some cases the pain may spread from the chest to the head, shoulder, or arm. The pain associated with PVA is caused by a spasm in the arteries that supply blood to the heart muscle (coronary arteries). This results in an obstruction of blood flow. In some people, persistent spasms increase the risk for serious complications such as a life-threatening arrhythmia or heart attack. PVA most commonly occurs in people who smoke and people who have high cholesterol or high blood pressure. In many cases it occurs for unknown reasons in otherwise healthy people. In some cases it may be triggered by alcohol withdrawal, stress, exposure to cold, certain medications, or use of stimulants such as cocaine. The diagnosis of PVA involves findings on an electrocardiogram, evidence of the spasms on angiogram, and relief of sudden symptoms with medicines called nitrates.","Curated_Disease_Description_Source__c":"GARD:0007465","GARD_Synonym__c":"angina inversa; angina pectoris, variant; coronary artery spasm angina; prinzmetal's angina; prinzmetal's variant angina; variant angina; variant angina pectoris","Name":"Prinzmetal angina","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"American Heart Association","Website__c":"https://www.heart.org"},{"Account_Name__c":"International Heart Spasms Alliance","Website__c":"https://www.internationalheartspasmsalliance.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Vascular Medicine","Tag_Category__c":"Specialist","curated_tag_name":"Vascular diseases"}],"External_Identifier_Disease__c":[{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=87343002","Source__c":"C0002963; MONDO:0006021","Xref__c":"87343002"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C000788","Source__c":"C0002963; MONDO:0006021","Xref__c":"D000788"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=295","Source__c":"C0002963","Xref__c":"MEDGEN:295"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0002963","Source__c":"C0002963","Xref__c":"C0002963"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A0111151","Source__c":"MONDO:0006021","Xref__c":"DOID:0111151"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C66915","Source__c":"C0002963","Xref__c":"C66915"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0006021","Source__c":"GARD:0007465","Xref__c":"MONDO:0006021"}],"tags":{"Specialist":["Vascular Medicine"]},"synonyms":["angina inversa"," angina pectoris, variant"," coronary artery spasm angina"," prinzmetal's angina"," prinzmetal's variant angina"," variant angina"," variant angina pectoris"]}