{"Name":"Shwartzman phenomenon","DiseaseID__c":"GARD:0007636","id":7636,"encodedName":"shwartzman-phenomenon","IsDeleted":false,"Disease_Name_Full__c":"Shwartzman phenomenon","Xref_IDs__c":"C0037018; D012790; DOID:3825; MEDGEN:48656; MONDO:0002783","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":1,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":2,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0002783","Disease_Description__c":"Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (endotoxins) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous thrombosis and necrosis. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of immune system, coagulation, fibrinolysis, and blood flow.","GARD_Name__c":"Shwartzman phenomenon","GARD_Synonym__c":"shwartzman reaction; shwartzman reaction (function); shwartzman reaction, function","Curated_Disease_Description_Source__c":"MEDGEN:C0037018","Curated_Disease_Description__c":"Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0002783","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow.","Curated_Disease_Description_Source__c":"MEDGEN:C0037018","GARD_Synonym__c":"shwartzman reaction; shwartzman reaction (function); shwartzman reaction, function","Name":"Shwartzman phenomenon","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Vascular Medicine","Tag_Category__c":"Specialist","curated_tag_name":"Vascular diseases"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0037018","Source__c":"C0037018","Xref__c":"C0037018"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=48656","Source__c":"C0037018","Xref__c":"MEDGEN:48656"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C012790","Source__c":"C0037018; MONDO:0002783","Xref__c":"D012790"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A3825","Source__c":"MONDO:0002783","Xref__c":"DOID:3825"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0002783","Source__c":"GARD:0007636","Xref__c":"MONDO:0002783"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=24453002","Source__c":"C0037018","Xref__c":"24453002"}],"tags":{"Specialist":["Vascular Medicine"]},"synonyms":["shwartzman reaction"," shwartzman reaction (function)"," shwartzman reaction, function"]}