{"Name":"Gastric cancer","DiseaseID__c":"GARD:0007704","id":7704,"encodedName":"gastric-cancer","IsDeleted":false,"Disease_Name_Full__c":"Gastric cancer","Xref_IDs__c":"C0024623; C16; C9331; DOID:10534; MEDGEN:44264; MONDO:0001056; OMIM:613659","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":2,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":2,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":3,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0001056","Disease_Description__c":"A primary or metastatic malignant neoplasm involving the stomach.","GARD_Name__c":"Gastric cancer","GARD_Synonym__c":"ca lesser curvature - stomach; cancer of stomach; gastric cancer risk after h. pylori infection; gastric cancer, somatic; gc; malignant gastric neoplasm; malignant gastric tumor; malignant gastric tumour; malignant neoplasm of lesser curve of stomach; malignant neoplasm of stomach; malignant neoplasm of the stomach; malignant stomach neoplasm; malignant tumor of body of stomach; malignant tumor of greater curve of stomach; malignant tumor of lesser curve of stomach; malignant tumor of stomach; malignant tumor of the stomach; malignant tumour of body of stomach; malignant tumour of greater curve of stomach; malignant tumour of lesser curve of stomach; malignant tumour of stomach; malignant tumour of the stomach; stomach cancer","Curated_Disease_Description_Source__c":"GARD:0007704","Curated_Disease_Description__c":"The stomach is an organ between the esophagus and the small intestine. It mixes food with stomach acid and helps digest protein. Stomach cancer mostly affects older people - two-thirds of people who have it are over age 65. Your risk of getting it is also higher if you have had a Helicobacter pylori infection, have had stomach inflammation, are a man, eat lots of salted, smoked, or pickled foods, smoke cigarettes, have a family history of stomach cancer.\r\n\r\nIt is hard to diagnose stomach cancer in its early stages. Indigestion and stomach discomfort can be symptoms of early cancer, but other problems can cause the same symptoms. In advanced cases, there may be blood in your stool, vomiting, unexplained weight loss, jaundice, or trouble swallowing. Doctors diagnose stomach cancer with a physical exam, blood and imaging tests, an endoscopy, and a biopsy.\r\n\r\nBecause it is often found late, it can be hard to treat stomach cancer. Treatment options include surgery, chemotherapy, radiation or a combination.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0001056","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"The stomach is an organ between the esophagus and the small intestine. It mixes food with stomach acid and helps digest protein. Stomach cancer mostly affects older people - two-thirds of people who have it are over age 65. Your risk of getting it is also higher if you have had a Helicobacter pylori infection, have had stomach inflammation, are a man, eat lots of salted, smoked, or pickled foods, smoke cigarettes, have a family history of stomach cancer.\r\n\r\nIt is hard to diagnose stomach cancer in its early stages. Indigestion and stomach discomfort can be symptoms of early cancer, but other problems can cause the same symptoms. In advanced cases, there may be blood in your stool, vomiting, unexplained weight loss, jaundice, or trouble swallowing. Doctors diagnose stomach cancer with a physical exam, blood and imaging tests, an endoscopy, and a biopsy.\r\n\r\nBecause it is often found late, it can be hard to treat stomach cancer. Treatment options include surgery, chemotherapy, radiation or a combination.","Curated_Disease_Description_Source__c":"GARD:0007704","GARD_Synonym__c":"ca lesser curvature - stomach; cancer of stomach; gastric cancer risk after h. pylori infection; gastric cancer, somatic; gc; malignant gastric neoplasm; malignant gastric tumor; malignant gastric tumour; malignant neoplasm of lesser curve of stomach; malignant neoplasm of stomach; malignant neoplasm of the stomach; malignant stomach neoplasm; malignant tumor of body of stomach; malignant tumor of greater curve of stomach; malignant tumor of lesser curve of stomach; malignant tumor of stomach; malignant tumor of the stomach; malignant tumour of body of stomach; malignant tumour of greater curve of stomach; malignant tumour of lesser curve of stomach; malignant tumour of stomach; malignant tumour of the stomach; stomach cancer","Name":"Gastric cancer","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Guts UK!","Website__c":"https://gutscharity.org.uk/"},{"Account_Name__c":"Rare Cancers Australia","Website__c":"http://rarecancers.org.au/"},{"Account_Name__c":"No Stomach For Cancer","Website__c":"https://www.nostomachforcancer.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0024623","Source__c":"C0024623","Xref__c":"C0024623"},{"URL__c":"https://www.omim.org/entry/613659","Source__c":"C0024623; MONDO:0001056","Xref__c":"OMIM:613659"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=44264","Source__c":"C0024623","Xref__c":"MEDGEN:44264"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A10534","Source__c":"MONDO:0001056","Xref__c":"DOID:10534"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9331","Source__c":"C0024623; MONDO:0001056","Xref__c":"C9331"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/C16","Source__c":"MONDO:0001056","Xref__c":"C16"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=363349007","Source__c":"C0024623","Xref__c":"363349007"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0001056","Source__c":"GARD:0007704","Xref__c":"MONDO:0001056"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0012126","Source__c":"C0024623","Xref__c":"HP:0012126"},{"URL__c":"https://www.cancer.gov/types/stomach/treatment"},{"URL__c":"https://medlineplus.gov/stomachcancer.html"}],"GARD_Disease_Gene__c":[{"GeneSymbol__c":"KRAS","GHR_URL__c":"https://medlineplus.gov/genetics/gene/kras","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"FGFR2","GHR_URL__c":"https://medlineplus.gov/genetics/gene/fgfr2","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"IL1RN","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"MUTYH","GHR_URL__c":"https://medlineplus.gov/genetics/gene/mutyh","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"ERBB2","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"IRF1","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"APC","GHR_URL__c":"https://medlineplus.gov/genetics/gene/apc","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"KLF6","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"IL1B","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"CASP10","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"PIK3CA","GHR_URL__c":"https://medlineplus.gov/genetics/gene/pik3ca","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true}],"GARD_Disease_Feature__c":[{"Provided_By__c":"OMIM:613659","Feature__r":{"HPO_Description__c":"A cancer arising in any part of the stomach.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012126","HPO_Synonym__c":"Gastric cancer","HPO_Name__c":"Stomach cancer","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"OMIM:613659","Feature__r":{"HPO_Description__c":"An increase in the level of L-fucose in the urine.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0410067","HPO_Name__c":"Increased level of L-fucose in urine","HPO_Feature_Type__c":"Lab"}}],"tags":{"Disease Category":["Cancer"]},"synonyms":["ca lesser curvature - stomach"," cancer of stomach"," gastric cancer risk after h. pylori infection"," gastric cancer, somatic"," gc"," malignant gastric neoplasm"," malignant gastric tumor"," malignant gastric tumour"," malignant neoplasm of lesser curve of stomach"," malignant neoplasm of stomach"," malignant neoplasm of the stomach"," malignant stomach neoplasm"," malignant tumor of body of stomach"," malignant tumor of greater curve of stomach"," malignant tumor of lesser curve of stomach"," malignant tumor of stomach"," malignant tumor of the stomach"," malignant tumour of body of stomach"," malignant tumour of greater curve of stomach"," malignant tumour of lesser curve of stomach"," malignant tumour of stomach"," malignant tumour of the stomach"," stomach cancer"]}