{"Name":"Trigeminal neuralgia","DiseaseID__c":"GARD:0007805","id":7805,"encodedName":"trigeminal-neuralgia","IsDeleted":false,"Disease_Name_Full__c":"Trigeminal neuralgia","Xref_IDs__c":"31681005; C0040997; D014277; DOID:12098; G50.0; HP:0100661; MEDGEN:21683; MONDO:0008599; OMIM:190400; ORPHA:221091","USA_Estimate__c":"50,000","No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":3,"World_Estimate__c":"80,000 to 800,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":3,"No_of_Disease_Descriptions__c":4,"Disease_Characteristics_Score__c":7,"No_of_Age_at_Onset__c":3,"Description_Source__c":"MONDO:0008599","Disease_Description__c":"Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of theface), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown. Treatment options include medicines, surgery, and complementary approaches.","GARD_Name__c":"Trigeminal neuralgia","GARD_Synonym__c":"fothergill's neuralgia; neuralgia of trigeminal nerve; tic douloureux; tn - trigeminal neuralgia; trifacial neuralgia; trifocal neuralgia; trigeminal nerve neuralgia","Curated_Disease_Description_Source__c":"GARD:0007805","Curated_Disease_Description__c":"Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of the face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"50,000","Age_at_Onset_Snippet_Text__c":"at a variety of ages","SourceID__c":"ORPHA:221091","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0008599","ORPHANET_ID__c":"ORPHA:221091","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Neuralgia trigeminal","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"neuralgia trigeminal","Spanish_GARD_Synonym__c":"tic doloroso","Category_Linearization__c":"ORPHA:98006","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of the face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown.","Curated_Disease_Description_Source__c":"GARD:0007805","GARD_Synonym__c":"fothergill's neuralgia; neuralgia of trigeminal nerve; tic douloureux; tn - trigeminal neuralgia; trifacial neuralgia; trifocal neuralgia; trigeminal nerve neuralgia","Name":"Trigeminal neuralgia","Curated_USA_Estimate__c":"50,000","estimateUsa":"50,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"OUCH (UK)","Website__c":"https://ouchuk.org/"},{"Account_Name__c":"Ben's Friends","Website__c":"https://www.bensfriends.org/"},{"Account_Name__c":"American Chronic Pain Association","Website__c":"https://www.acpanow.com/"},{"Account_Name__c":"Facial Pain Association","Website__c":"https://www.facepain.org/"},{"Account_Name__c":"Trigeminal Neuralgia Association UK","Website__c":"https://www.tna.org.uk/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Neurology","Tag_Category__c":"Disease Category;Specialist","category_description":"Neurological diseases affect the brain, spinal cord, cranial nerves, autonomic nerves, or other peripheral nerves.","curated_tag_name":"Neurological diseases"},{"Tag_Name__c":"Peripheral Neuropathy","Tag_Category__c":"Account","curated_tag_name":"Peripheral neuropathy"},{"Tag_Name__c":"Neuromuscular medicine","Tag_Category__c":"Specialist","curated_tag_name":"Neuromuscular medicine"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adolescent","Provided_By__c":"ORPHA:221091"},{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:221091"},{"Age_At_Onset__c":"Elderly","Provided_By__c":"ORPHA:221091"}],"Diagnosis__c":[{"Type__c":"GTR","Curie__c":"MEDGEN:C0040997"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C014277","Source__c":"C0040997; MONDO:0008599","Xref__c":"D014277"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=31681005","Source__c":"C0040997; MONDO:0008599","Xref__c":"31681005"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/G50.0","Source__c":"MONDO:0008599","Xref__c":"G50.0"},{"URL__c":"https://www.omim.org/entry/190400","Source__c":"C0040997; MONDO:0008599; ORPHA:221091","Xref__c":"OMIM:190400"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=21683","Source__c":"C0040997","Xref__c":"MEDGEN:21683"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0040997","Source__c":"C0040997","Xref__c":"C0040997"},{"URL__c":"https://www.orpha.net/en/disease/detail/221091","Source__c":"C0040997; MONDO:0008599; ORPHA:221091","Xref__c":"ORPHA:221091"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A12098","Source__c":"MONDO:0008599","Xref__c":"DOID:12098"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0100661","Source__c":"C0040997","Xref__c":"HP:0100661"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0008599","Source__c":"GARD:0007805","Xref__c":"MONDO:0008599"},{"URL__c":"https://medlineplus.gov/trigeminalneuralgia.html"},{"URL__c":"https://www.ninds.nih.gov/health-information/disorders/trigeminal-neuralgia"},{"URL__c":"https://www.nidcr.nih.gov/health-info/trigeminal-neuralgia"}],"Inheritance__c":["Autosomal dominant"],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:221091","HPO_Frequency__c":"Always (100%)","Feature__r":{"HPO_Description__c":"A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100661","HPO_Synonym__c":"Tic douloureux","HPO_Name__c":"Trigeminal neuralgia","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:221091","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002465","HPO_Synonym__c":"Poor speech","HPO_Name__c":"Poor speech","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:221091","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Impaired ability to eat related to problems gathering food and getting ready to suck, chew, or swallow it.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0011968","HPO_Synonym__c":"Decreased oral intake; Feeding difficulties; Feeding problems; Poor feeding","HPO_Name__c":"Feeding difficulties","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:221091","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A loss of myelin from nerve fibers in the central nervous system.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0007305","HPO_Synonym__c":"Demyelination in central white matter","HPO_Name__c":"CNS demyelination","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:221091","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An abnormality of the primary sensation that is mediated by peripheral nerves (pain, temperature, touch, vibration, joint position). The word hypoesthesia (or hypesthesia) refers to a reduction in cutaneous sensation to a specific type of testing.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0003474","HPO_Synonym__c":"Sensory impairment","HPO_Name__c":"Somatic sensory dysfunction","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:221091","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Reduced strength of the tongue musculature, resulting in difficulties moving the tongue and possible accompanied by dysarthria or dysphagia.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000183","HPO_Name__c":"Tongue muscle weakness","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:221091","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Pain due to a stimulus that does not normally provoke pain.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012533","HPO_Name__c":"Allodynia","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:221091","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the mandible.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0200025","HPO_Synonym__c":"Lower jaw pain","HPO_Name__c":"Mandibular pain","Feature_System__c":"Musculoskeletal System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:221091","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Frequently experiencing feelings of being down, miserable, and/or hopeless; struggling to recover from these moods; having a pessimistic outlook on the future; feeling a pervasive sense of shame; having a low self-worth; experiencing thoughts of suicide and engaging in suicidal behavior.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000716","HPO_Synonym__c":"Depression; Depressive episode; Depressivity","HPO_Name__c":"Depression","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:221091","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001293","HPO_Name__c":"Cranial nerve compression","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:221091","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Abnormal twisting of arteries or veins.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0004948","HPO_Synonym__c":"Twisted blood vessels","HPO_Name__c":"Vascular tortuosity","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:221091","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002664","HPO_Synonym__c":"Neoplasia; 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Pins and needles feeling; Tingling","HPO_Name__c":"Paresthesia","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:221091","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the eye.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0200026","HPO_Synonym__c":"Eye pain","HPO_Name__c":"Ocular pain","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Disease Category":["Neurology"],"Specialist":["Neurology","Neuromuscular medicine","Pediatrics"],"Account":["Peripheral Neuropathy"]},"synonyms":["fothergill's neuralgia"," neuralgia of trigeminal nerve"," tic douloureux"," tn - trigeminal neuralgia"," trifacial neuralgia"," trifocal neuralgia"," trigeminal nerve neuralgia"]}