{"Name":"Tuberculosis","DiseaseID__c":"GARD:0007827","id":7827,"encodedName":"tuberculosis","IsDeleted":false,"Disease_Name_Full__c":"Tuberculosis","Xref_IDs__c":"56717001; A15-A19; C0041296; C3423; D014376; DOID:399; MEDGEN:22513; MONDO:0018076; ORPHA:3389","USA_Estimate__c":"50,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":2,"World_Estimate__c":"80,000 to 800,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":2,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0018076","Disease_Description__c":"A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use.","GARD_Name__c":"Tuberculosis","GARD_Synonym__c":"infection caused by mycobacterium tuberculosis; tb - tuberculosis; tuberculosis disease; tuberculous","Curated_Disease_Description_Source__c":"MONDO:0018076","Curated_Disease_Description__c":"Tuberculosis (TB) is a bacterial disease that usually attacks the lungs. But it can also attack other parts of the body, including the kidneys, spine, and brain.\r\n\r\nNot everyone infected with TB bacteria (germs) becomes sick. So, there are two types of TB conditions: 1) inactive (latent) TB infection, where the TB germs live in your body but don't make you sick and 2) TB disease (active TB) where you get sick from the TB germs. TB disease can almost always be cured with antibiotics. But if it's not treated properly, it can be fatal.\r\n\r\nTB is found in the U.S., but it is more common in certain other countries.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"50,000","Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:3389","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0018076","ORPHANET_ID__c":"ORPHA:3389","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Tuberculosis","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"tuberculosis","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:68416","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Tuberculosis (TB) is a bacterial disease that usually attacks the lungs. But it can also attack other parts of the body, including the kidneys, spine, and brain.\r\n\r\nNot everyone infected with TB bacteria (germs) becomes sick. So, there are two types of TB conditions: 1) inactive (latent) TB infection, where the TB germs live in your body but don't make you sick and 2) TB disease (active TB) where you get sick from the TB germs. TB disease can almost always be cured with antibiotics. But if it's not treated properly, it can be fatal.\r\n\r\nTB is found in the U.S., but it is more common in certain other countries.","Curated_Disease_Description_Source__c":"MONDO:0018076","GARD_Synonym__c":"infection caused by mycobacterium tuberculosis; tb - tuberculosis; tuberculosis disease; tuberculous","Name":"Tuberculosis","Curated_USA_Estimate__c":"50,000","estimateUsa":"50,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"American Lung Association","Website__c":"https://www.lung.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Infectious Disease","Tag_Category__c":"Disease Category;Specialist","category_description":"Infectious diseases are caused by bacteria, viruses, fungi, or parasites entering the body, multiplying, and spreading illness.","curated_tag_name":"Infectious diseases"},{"Tag_Name__c":"Rare Bacterial Infectious Disease","Tag_Category__c":"Cause","curated_tag_name":"Bacterial Infectious Disease"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:3389"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=22513","Source__c":"C0041296","Xref__c":"MEDGEN:22513"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/A15-A19","Source__c":"MONDO:0018076","Xref__c":"A15-A19"},{"URL__c":"https://www.orpha.net/en/disease/detail/3389","Source__c":"C0041296; MONDO:0018076; ORPHA:3389","Xref__c":"ORPHA:3389"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A399","Source__c":"MONDO:0018076","Xref__c":"DOID:399"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C014376","Source__c":"C0041296; MONDO:0018076","Xref__c":"D014376"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=56717001","Source__c":"C0041296; MONDO:0018076","Xref__c":"56717001"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3423","Source__c":"C0041296; MONDO:0018076","Xref__c":"C3423"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0041296","Source__c":"C0041296","Xref__c":"C0041296"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0018076","Source__c":"GARD:0007827","Xref__c":"MONDO:0018076"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=371569005","Source__c":"C0041296","Xref__c":"371569005"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=373576009","Source__c":"C0041296","Xref__c":"373576009"},{"URL__c":"https://medlineplus.gov/tuberculosis.html"},{"URL__c":"https://www.niaid.nih.gov/diseases-conditions/tuberculosis"}],"tags":{"Disease Category":["Infectious Disease"],"Specialist":["Infectious Disease","Pediatrics"],"Cause":["Rare Bacterial Infectious Disease"]},"synonyms":["infection caused by mycobacterium tuberculosis"," tb - tuberculosis"," tuberculosis disease"," tuberculous"]}