{"Name":"Mediastinal yolk sac tumor","DiseaseID__c":"GARD:0008258","id":8258,"encodedName":"mediastinal-yolk-sac-tumor","IsDeleted":false,"Disease_Name_Full__c":"Mediastinal yolk sac tumor","Xref_IDs__c":"C1334683; C6443; MEDGEN:233176; MONDO:0023726","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":1,"Disease_Characteristics_Score__c":1,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0023726","Disease_Description__c":"An extragonadal non-seminomatous malignant germ cell tumor that arises from the mediastinum. It is characterized by the presence of small pale cells with small amount of cytoplasm and round to oval nuclei with small nucleoli forming a variety of patterns, including microcystic, macrocystic, pseudopapillary, myxomatous, hepatoid, polyvesicular vitelline, and solid. It manifests with respiratory distress, thoracic pain, fever, and superior vena cava syndrome.","GARD_Name__c":"Mediastinal yolk sac tumor","GARD_Synonym__c":"endodermal sinus neoplasm of mediastinum; endodermal sinus neoplasm of the mediastinum; endodermal sinus tumor of mediastinum; endodermal sinus tumor of the mediastinum; endodermal sinus tumour of mediastinum; endodermal sinus tumour of the mediastinum; mediastinal endodermal sinus neoplasm; mediastinal endodermal sinus tumor; mediastinal endodermal sinus tumour; mediastinal yolk sac neoplasm; mediastinal yolk sac tumour; mediastinum yolk sac tumor; mediastinum yolk sac tumour; yolk sac neoplasm of mediastinum; yolk sac neoplasm of the mediastinum; yolk sac tumor of mediastinum; yolk sac tumor of the mediastinum; yolk sac tumour of mediastinum; yolk sac tumour of the mediastinum","Curated_Disease_Description_Source__c":"MONDO:0023726","Curated_Disease_Description__c":"An extragonadal non-seminomatous malignant germ cell tumor that arises from the mediastinum. It is characterized by the presence of small pale cells with small amount of cytoplasm and round to oval nuclei with small nucleoli forming a variety of patterns, including microcystic, macrocystic, pseudopapillary, myxomatous, hepatoid, polyvesicular vitelline, and solid. It manifests with respiratory distress, thoracic pain, fever, and superior vena cava syndrome.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0023726","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"An extragonadal non-seminomatous malignant germ cell tumor that arises from the mediastinum. It is characterized by the presence of small pale cells with small amount of cytoplasm and round to oval nuclei with small nucleoli forming a variety of patterns, including microcystic, macrocystic, pseudopapillary, myxomatous, hepatoid, polyvesicular vitelline, and solid. It manifests with respiratory distress, thoracic pain, fever, and superior vena cava syndrome.","Curated_Disease_Description_Source__c":"MONDO:0023726","GARD_Synonym__c":"endodermal sinus neoplasm of mediastinum; endodermal sinus neoplasm of the mediastinum; endodermal sinus tumor of mediastinum; endodermal sinus tumor of the mediastinum; endodermal sinus tumour of mediastinum; endodermal sinus tumour of the mediastinum; mediastinal endodermal sinus neoplasm; mediastinal endodermal sinus tumor; mediastinal endodermal sinus tumour; mediastinal yolk sac neoplasm; mediastinal yolk sac tumour; mediastinum yolk sac tumor; mediastinum yolk sac tumour; yolk sac neoplasm of mediastinum; yolk sac neoplasm of the mediastinum; yolk sac tumor of mediastinum; yolk sac tumor of the mediastinum; yolk sac tumour of mediastinum; yolk sac tumour of the mediastinum","Name":"Mediastinal yolk sac tumor","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C1334683","Source__c":"C1334683","Xref__c":"C1334683"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=233176","Source__c":"C1334683","Xref__c":"MEDGEN:233176"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C6443","Source__c":"C1334683; MONDO:0023726","Xref__c":"C6443"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0023726","Source__c":"GARD:0008258","Xref__c":"MONDO:0023726"}],"tags":{"Disease Category":["Cancer"]},"synonyms":["endodermal sinus neoplasm of mediastinum"," endodermal sinus neoplasm of the mediastinum"," endodermal sinus tumor of mediastinum"," endodermal sinus tumor of the mediastinum"," endodermal sinus tumour of mediastinum"," endodermal sinus tumour of the mediastinum"," mediastinal endodermal sinus neoplasm"," mediastinal endodermal sinus tumor"," mediastinal endodermal sinus tumour"," mediastinal yolk sac neoplasm"," mediastinal yolk sac tumour"," mediastinum yolk sac tumor"," mediastinum yolk sac tumour"," yolk sac neoplasm of mediastinum"," yolk sac neoplasm of the mediastinum"," yolk sac tumor of mediastinum"," yolk sac tumor of the mediastinum"," yolk sac tumour of mediastinum"," yolk sac tumour of the mediastinum"]}