{"Name":"IgG4-related mediastinitis","DiseaseID__c":"GARD:0008337","id":8337,"encodedName":"igg4-related-mediastinitis","IsDeleted":false,"Disease_Name_Full__c":"IgG4-related mediastinitis","Xref_IDs__c":"C0264573; C536136; MEDGEN:82683; MONDO:0018978; ORPHA:63999","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":2,"No_of_Age_at_Onset__c":0,"Description_Source__c":"GARD:0008337","Disease_Description__c":"Fibrosing mediastinitis is a condition that affects the area between the lungs (mediastinum) which contains the heart, large blood vessels, windpipe (trachea), esophagus, and lymph nodes. People with Fibrosing mediastinitis have varying amounts of scar tissue in the mediastinum which may cause problems for the organs located there. For example, some affected people may develop blocked airways that can interfere with lung function. Others may have compressed blood vessels which can slow or prevent blood flow to and from the heart. The exact cause of Fibrosing mediastinitis is not fully understood, but it is not inherited. Many cases are linked to a specific type of fungal infection called histoplasmosis.","GARD_Name__c":"IgG4-related mediastinitis","GARD_Synonym__c":"fibrosing mediastinitis; fibrosis of mediastinum; fibrous mediastinitis; idiopathic hilar fibrosis; idiopathic mediastinal fibrosis; mediastinal fibrosis; sclerosing mediastinitis","Curated_Disease_Description_Source__c":"GARD:0008337","Curated_Disease_Description__c":"IgG4-related mediastinitis is a condition that affects the area between the lungs (mediastinum) which contains the heart, large blood vessels, windpipe (trachea), esophagus, and lymph nodes. People with IgG4-related mediastinitis have varying amounts of scar tissue in the mediastinum which may cause problems for the organs located there. For example, some affected people may develop blocked airways that can interfere with lung function. Others may have compressed blood vessels which can slow or prevent blood flow to and from the heart. The exact cause of IgG4-related mediastinitis is not fully understood, but it is not inherited. Many cases are linked to a specific type of fungal infection called histoplasmosis.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":"ORPHA:63999","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0018978","ORPHANET_ID__c":"ORPHA:63999","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Mediastinitis asociada a igg4","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"mediastinitis asociada a igg4","Spanish_GARD_Synonym__c":"fibrosis mediastínica; mediastinitis esclerosante; mediastinitis fibrosante","Category_Linearization__c":"ORPHA:97955","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"IgG4-related mediastinitis is a condition that affects the area between the lungs (mediastinum) which contains the heart, large blood vessels, windpipe (trachea), esophagus, and lymph nodes. People with IgG4-related mediastinitis have varying amounts of scar tissue in the mediastinum which may cause problems for the organs located there. For example, some affected people may develop blocked airways that can interfere with lung function. Others may have compressed blood vessels which can slow or prevent blood flow to and from the heart. The exact cause of IgG4-related mediastinitis is not fully understood, but it is not inherited. Many cases are linked to a specific type of fungal infection called histoplasmosis.","Curated_Disease_Description_Source__c":"GARD:0008337","GARD_Synonym__c":"fibrosing mediastinitis; fibrosis of mediastinum; fibrous mediastinitis; idiopathic hilar fibrosis; idiopathic mediastinal fibrosis; mediastinal fibrosis; sclerosing mediastinitis","Name":"IgG4-related mediastinitis","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Pulmonology","Tag_Category__c":"Disease Category;Specialist","category_description":"Respiratory diseases affect the nose, mouth, throat, voice box, windpipe, lungs, or blood vessels.","curated_tag_name":"Respiratory diseases"},{"Tag_Name__c":"Rheumatology","Tag_Category__c":"Specialist"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0264573","Source__c":"C0264573","Xref__c":"C0264573"},{"URL__c":"https://www.orpha.net/en/disease/detail/63999","Source__c":"C0264573; MONDO:0018978; ORPHA:63999","Xref__c":"ORPHA:63999"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C536136","Source__c":"MONDO:0018978","Xref__c":"C536136"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=82683","Source__c":"C0264573","Xref__c":"MEDGEN:82683"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0018978","Source__c":"GARD:0008337","Xref__c":"MONDO:0018978"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=7377003","Source__c":"C0264573","Xref__c":"7377003"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=21247003","Source__c":"C0264573","Xref__c":"21247003"}],"tags":{"Disease Category":["Pulmonology"],"Specialist":["Pulmonology","Rheumatology"]},"synonyms":["fibrosing mediastinitis"," fibrosis of mediastinum"," fibrous mediastinitis"," idiopathic hilar fibrosis"," idiopathic mediastinal fibrosis"," mediastinal fibrosis"," sclerosing mediastinitis"]}