{"Name":"Acute hemorrhagic leukoencephalitis","DiseaseID__c":"GARD:0008629","id":8629,"encodedName":"acute-hemorrhagic-leukoencephalitis","IsDeleted":false,"Disease_Name_Full__c":"Acute hemorrhagic leukoencephalitis","Xref_IDs__c":"72986009; C0014077; C84535; D004684; DOID:10992; MEDGEN:4937; MONDO:0011716; OMIM:606752","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":2,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0011716","Disease_Description__c":"Acute hemorrhagic leukoencephalitis(AHL) is a veryrareform of acute disseminated encephalomyelitis that usuallyresults indeath. It is characterized by a brief but intense attack of inflammation in the brain and spinal cord that damages the myelin -- the protective covering of the nerve fibers. It may also cause bleeding in the brain, leading to damage of the white matter. Symptoms usually come on quickly, beginning with symptoms such as fever, neck stiffness, fatigue, headache, nausea vomiting,seizures, and coma.AHL has a very poor prognosis, with rapid deterioration and death usually occurring within days to one week after onset of symptoms because of severe inflammation in the brain. Although the exact cause is unclear,AHL usually followsaviral infection, or less often, vaccination for measles, mumps, or rubella. Some researchers think that an infection or vaccination can initiate an autoimmune process in the body thus leading to AHL.","GARD_Name__c":"Acute hemorrhagic leukoencephalitis","GARD_Synonym__c":"acute haemorrhagic leucoencephalitis of weston hurst; acute hemorrhagic encephalomyelitis; acute hemorrhagic leukoencephalitis of weston hurst; acute necrotizing hemorrhagic leukoencephalitis; ahl; hurst's disease; weston-hurst syndrome","Curated_Disease_Description_Source__c":"GARD:0008629","Curated_Disease_Description__c":"Acute hemorrhagic leukoencephalitis (AHLE) is a rare form of acute disseminated encephalomyelitis. It is characterized by a brief but intense attack of inflammation in the brain and spinal cord that damages the myelin (the protective covering of the nerve fibers). It may also cause bleeding in the brain, leading to damage of the white matter. Symptoms usually come on quickly and may include fever, neck stiffness, fatigue, headache, nausea, vomiting, seizures, and coma. Although the exact cause is unclear, AHLE usually follows a viral or bacterial infection, or less often, vaccination for measles or rabies.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0011716","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Acute hemorrhagic leukoencephalitis (AHLE) is a rare form of acute disseminated encephalomyelitis. It is characterized by a brief but intense attack of inflammation in the brain and spinal cord that damages the myelin (the protective covering of the nerve fibers). It may also cause bleeding in the brain, leading to damage of the white matter. Symptoms usually come on quickly and may include fever, neck stiffness, fatigue, headache, nausea, vomiting, seizures, and coma. Although the exact cause is unclear, AHLE usually follows a viral or bacterial infection, or less often, vaccination for measles or rabies.","Curated_Disease_Description_Source__c":"GARD:0008629","GARD_Synonym__c":"acute haemorrhagic leucoencephalitis of weston hurst; acute hemorrhagic encephalomyelitis; acute hemorrhagic leukoencephalitis of weston hurst; acute necrotizing hemorrhagic leukoencephalitis; ahl; hurst's disease; weston-hurst syndrome","Name":"Acute hemorrhagic leukoencephalitis","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Global Autoimmune Institute","Website__c":"https://www.autoimmuneinstitute.org/"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C004684","Source__c":"C0014077; MONDO:0011716","Xref__c":"D004684"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A10992","Source__c":"MONDO:0011716","Xref__c":"DOID:10992"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0014077","Source__c":"C0014077","Xref__c":"C0014077"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C84535","Source__c":"C0014077; MONDO:0011716","Xref__c":"C84535"},{"URL__c":"https://www.omim.org/entry/606752","Source__c":"C0014077; MONDO:0011716","Xref__c":"OMIM:606752"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=72986009","Source__c":"C0014077; MONDO:0011716","Xref__c":"72986009"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=4937","Source__c":"C0014077","Xref__c":"MEDGEN:4937"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0011716","Source__c":"GARD:0008629","Xref__c":"MONDO:0011716"}],"tags":{},"synonyms":["acute haemorrhagic leucoencephalitis of weston hurst"," acute hemorrhagic encephalomyelitis"," acute hemorrhagic leukoencephalitis of weston hurst"," acute necrotizing hemorrhagic leukoencephalitis"," ahl"," hurst's disease"," weston-hurst syndrome"]}