{"Name":"Limbic encephalitis","DiseaseID__c":"GARD:0008742","id":8742,"encodedName":"limbic-encephalitis","IsDeleted":false,"Disease_Name_Full__c":"Limbic encephalitis","Xref_IDs__c":"230192003; C0338430; C4350; D020363; DOID:0080741; MEDGEN:137895; MONDO:0015588","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":2,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0015588","Disease_Description__c":"A group of autoimmune conditions characterized by inflammation of the limbic system and other parts of the brain.The cardinal sign of limbic encephalitis is a severe impairment of short-term memory; however,symptoms may also include confusion, psychiatric symptoms, and seizures.The symptomstypically develop over a few weeks or months, but they may evolve over a few days. Limbic encephalitis is often associated with an underlying neoplasm (paraneoplastic limbic encephalitis); however some cases never have a neoplasm identified (non-paraneoplastic limbic encephalitis). Delayed diagnosis is common, but improvements are being made to assist in early detection. Various tests including imaging studies (MRI, PET) laboratory tests (CSF analysis), and tests that measure the electrical activity of the brain (EEG) may be utilized to confirm a diagnosis. Treatment includes removal of the neoplasm (if identified) and immunotherapy.","GARD_Name__c":"Limbic encephalitis","GARD_Synonym__c":"limbic encephalopathy","Curated_Disease_Description_Source__c":"GARD:0008742","Curated_Disease_Description__c":"Limbic encephalitis represents a group of autoimmune conditions characterized by inflammation of the limbic system and other parts of the brain. The cardinal sign of Limbic encephalitis is a severe impairment of short-term memory; however, symptoms may also include confusion, psychiatric symptoms, and seizures. The symptoms typically develop over a few weeks or months, but they may evolve over a few days. Limbic encephalitis is often associated with an underlying neoplasm (paraneoplastic Limbic encephalitis); however some cases never have a neoplasm identified (non-paraneoplastic Limbic encephalitis). Various tests including imaging studies, laboratory tests, and tests that measure the electrical activity of the brain (EEG) may be utilized to confirm a diagnosis.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0015588","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Limbic encephalitis represents a group of autoimmune conditions characterized by inflammation of the limbic system and other parts of the brain. The cardinal sign of Limbic encephalitis is a severe impairment of short-term memory; however, symptoms may also include confusion, psychiatric symptoms, and seizures. The symptoms typically develop over a few weeks or months, but they may evolve over a few days. Limbic encephalitis is often associated with an underlying neoplasm (paraneoplastic Limbic encephalitis); however some cases never have a neoplasm identified (non-paraneoplastic Limbic encephalitis). Various tests including imaging studies, laboratory tests, and tests that measure the electrical activity of the brain (EEG) may be utilized to confirm a diagnosis.","Curated_Disease_Description_Source__c":"GARD:0008742","GARD_Synonym__c":"limbic encephalopathy","Name":"Limbic encephalitis","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Encephalitis411","Website__c":"https://encephalitis411.org/"},{"Account_Name__c":"Encephalitis Society","Website__c":"https://www.encephalitis.info/"},{"Account_Name__c":"International Autoimmune Encephalitis Society","Website__c":"https://autoimmune-encephalitis.org/"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C020363","Source__c":"C0338430; MONDO:0015588","Xref__c":"D020363"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=230192003","Source__c":"C0338430; MONDO:0015588","Xref__c":"230192003"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=137895","Source__c":"C0338430","Xref__c":"MEDGEN:137895"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0338430","Source__c":"C0338430","Xref__c":"C0338430"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A0080741","Source__c":"MONDO:0015588","Xref__c":"DOID:0080741"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0015588","Source__c":"GARD:0008742","Xref__c":"MONDO:0015588"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=445014002","Source__c":"C0338430","Xref__c":"445014002"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4350","Source__c":"C0338430","Xref__c":"C4350"}],"tags":{},"synonyms":["limbic encephalopathy"]}