{"Name":"Cervical intraepithelial neoplasia","DiseaseID__c":"GARD:0009244","id":9244,"encodedName":"cervical-intraepithelial-neoplasia","IsDeleted":false,"Disease_Name_Full__c":"Cervical intraepithelial neoplasia","Xref_IDs__c":"285636001; C0206708; C3782; HP:0032242; MEDGEN:60214; MONDO:0022394","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":1,"Disease_Characteristics_Score__c":1,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MEDGEN:C0206708","Disease_Description__c":"A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992)","GARD_Name__c":"Cervical intraepithelial neoplasia","GARD_Synonym__c":"cin - cervical intraepithelial neoplasia","Curated_Disease_Description_Source__c":"MEDGEN:C0206708","Curated_Disease_Description__c":"A precancerous condition characterized by dysplasia of the cervical epithelium. Cervical intraepithelial neoplasia (CIN) 1, 2 and 3 based on its relationship with the prognosis. CIN 1 is mild dysplasia, which is mostly observed because it disappears as part of its natural course. CIN 3 includes severe dysplasia and carcinoma in situ, and management involves treatment because it is highly likely to develop into invasive cancer.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0022394","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"A precancerous condition characterized by dysplasia of the cervical epithelium. Cervical intraepithelial neoplasia (CIN) 1, 2 and 3 based on its relationship with the prognosis. CIN 1 is mild dysplasia, which is mostly observed because it disappears as part of its natural course. CIN 3 includes severe dysplasia and carcinoma in situ, and management involves treatment because it is highly likely to develop into invasive cancer.","Curated_Disease_Description_Source__c":"MEDGEN:C0206708","GARD_Synonym__c":"cin - cervical intraepithelial neoplasia","Name":"Cervical intraepithelial neoplasia","estimateUsa":""}],"External_Identifier_Disease__c":[{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=285636001","Source__c":"C0206708; MONDO:0022394","Xref__c":"285636001"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=60214","Source__c":"C0206708","Xref__c":"MEDGEN:60214"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3782","Source__c":"C0206708; MONDO:0022394","Xref__c":"C3782"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0206708","Source__c":"C0206708","Xref__c":"C0206708"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0022394","Source__c":"GARD:0009244","Xref__c":"MONDO:0022394"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0032242","Source__c":"C0206708","Xref__c":"HP:0032242"}],"tags":{},"synonyms":["cin - cervical intraepithelial neoplasia"]}