{"Name":"SUNCT syndrome","DiseaseID__c":"GARD:0009257","id":9257,"encodedName":"sunct-syndrome","IsDeleted":false,"Disease_Name_Full__c":"SUNCT syndrome","Xref_IDs__c":"725058003; C1262087; C85174; D050798; MEDGEN:224724; MONDO:0018927; ORPHA:57145","USA_Estimate__c":"50,000","No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"80,000 to 800,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0018927","Disease_Description__c":"A rare primary headache disorder characterized by unilateral trigeminal pain that occurs in association with ipsilateral cranial autonomic symptoms (conjunctival injection and tearing).","GARD_Name__c":"SUNCT syndrome","GARD_Synonym__c":"short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing; short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing syndrome; short-lasting, unilateral, neuralgiform headache attacks with conjunctival injection and tearing; sunct (short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing) syndrome; sunct headache","Curated_Disease_Description_Source__c":"MONDO:0018927","Curated_Disease_Description__c":"A rare primary headache disorder characterized by unilateral trigeminal pain that occurs in association with ipsilateral cranial autonomic symptoms (conjunctival injection and tearing).","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"50,000","Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:57145","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0018927","ORPHANET_ID__c":"ORPHA:57145","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Síndrome sunct","Spanish_Description_Source__c":"ORPHA:57145","Spanish_Description__c":"Es una cefalea primaria poco frecuente caracterizada por dolor unilateral del trigémino asociado a síntomas autonómicos craneales ipsilaterales (inyección conjuntival y lagrimeo).","Spanish_Disease_Name__c":"síndrome sunct","Spanish_GARD_Synonym__c":"cefalea unilateral neuralgiforme de breve duración con reacción conjuntival y lagrimeo","Category_Linearization__c":"ORPHA:98006","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"A rare primary headache disorder characterized by unilateral trigeminal pain that occurs in association with ipsilateral cranial autonomic symptoms (conjunctival injection and tearing).","Curated_Disease_Description_Source__c":"MONDO:0018927","GARD_Synonym__c":"short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing; short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing syndrome; short-lasting, unilateral, neuralgiform headache attacks with conjunctival injection and tearing; sunct (short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing) syndrome; sunct headache","Name":"SUNCT syndrome","Curated_USA_Estimate__c":"50,000","estimateUsa":"50,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"OUCH (UK)","Website__c":"https://ouchuk.org/"},{"Account_Name__c":"The Migraine Trust","Website__c":"https://www.migrainetrust.org/"},{"Account_Name__c":"National Headache Foundation","Website__c":"https://headaches.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Neurology","Tag_Category__c":"Disease Category;Specialist","category_description":"Neurological diseases affect the brain, spinal cord, cranial nerves, autonomic nerves, or other peripheral nerves.","curated_tag_name":"Neurological diseases"},{"Tag_Name__c":"Vascular Neurology","Tag_Category__c":"Specialist","curated_tag_name":"Vascular neurology"},{"Tag_Name__c":"Vascular Medicine","Tag_Category__c":"Specialist","curated_tag_name":"Vascular diseases"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:57145"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C050798","Source__c":"C1262087; MONDO:0018927","Xref__c":"D050798"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C85174","Source__c":"C1262087; MONDO:0018927","Xref__c":"C85174"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C1262087","Source__c":"C1262087","Xref__c":"C1262087"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=725058003","Source__c":"C1262087; MONDO:0018927","Xref__c":"725058003"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=224724","Source__c":"C1262087","Xref__c":"MEDGEN:224724"},{"URL__c":"https://www.orpha.net/en/disease/detail/57145","Source__c":"C1262087; MONDO:0018927; ORPHA:57145","Xref__c":"ORPHA:57145"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0018927","Source__c":"GARD:0009257","Xref__c":"MONDO:0018927"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Intermittent episodes of abnormally increased perspiration.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001069","HPO_Synonym__c":"Hyperhidrosis, episodic; Sporadic excessive sweating","HPO_Name__c":"Episodic hyperhidrosis","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Abnormal (non-physiological) constriction of the pupil.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000616","HPO_Synonym__c":"Constricted pupils; Pupillary constriction","HPO_Name__c":"Miosis","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Abnormal excessive perspiration (sweating) despite the lack of appropriate stimuli like hot and humid weather.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000975","HPO_Synonym__c":"Diaphoresis; Excessive sweating; Increased sweating; Profuse sweating; Sweating; Sweating profusely; Sweating, increased","HPO_Name__c":"Hyperhidrosis","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Abnormally increased lacrimation, that is, excessive tearing (watering eye).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0009926","HPO_Synonym__c":"Increased lacrimation; Increased tears; Tearing; Watery eyes","HPO_Name__c":"Epiphora","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the jaw.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0040264","HPO_Synonym__c":"Jaw pain","HPO_Name__c":"Jaw pain","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Edema in the region of the eyelids.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100540","HPO_Synonym__c":"Edema of the eyelids; Eyelid edema; Fullness of eyelids; Puffy eyelids; Puffy lids; Swelling of eyelids","HPO_Name__c":"Palpebral edema","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Dilatation of the blood vessels of the conjunctiva leading to a red appearance of the sclera.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0030953","HPO_Synonym__c":"Conjunctival injection; Conjunctival vascular congestion","HPO_Name__c":"Conjunctival hyperemia","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Increased lacrimation owing to overproduction of tears.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0031731","HPO_Name__c":"Increased tear production","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002076","HPO_Synonym__c":"Intermittent migraine headaches; Migraine; Migraine headache; Migraine headaches","HPO_Name__c":"Migraine","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Pain in the ear can be a consequence of otologic disease (primary or otogenic otalgia), or can arise from pathologic processes and structures other than the ear (secondary or referred otalgia).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0030766","HPO_Synonym__c":"Ear pain; Otalgia; Pain in the ear","HPO_Name__c":"Ear pain","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"A state of unease is characterized by diffuse motor activity or motion, which is subject to limited control, nonproductive, or disorganized behavior.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000711","HPO_Synonym__c":"Fidgetiness; Restiveness","HPO_Name__c":"Restlessness","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"The upper eyelid margin is positioned 3 mm or more lower than usual and covers the superior portion of the iris (objective); or, the upper lid margin obscures at least part of the pupil (subjective).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000508","HPO_Synonym__c":"Blepharoptosis; Drooping upper eyelid; Eyelid ptosis; Palpebral ptosis","HPO_Name__c":"Ptosis","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Intermittent pain, i.e., pain that occurs occasionally and at irregular intervals.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0032148","HPO_Name__c":"Episodic pain","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Recurrent episodes of redness of the skin together with a sensation of warmth or burning of the affected areas of skin.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0031284","HPO_Name__c":"Flushing","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100661","HPO_Synonym__c":"Tic douloureux","HPO_Name__c":"Trigeminal neuralgia","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"A state of excessive motor activity that is associated with mental distress or a feeling of substantial unease or inner tension. Distinguished from restlessness by the increased level of emotional distress and negative intensity of the experience. Agitation has a significant level of physical activity that is typically threatening to the self or others.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000713","HPO_Synonym__c":"Psychomotor agitation","HPO_Name__c":"Agitation","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000282","HPO_Synonym__c":"Facial puffiness; Facial swelling; Swelling of the face","HPO_Name__c":"Facial edema","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Increased discharge of mucus from the nose.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0031417","HPO_Synonym__c":"Nasal Discharge; Runny Nose","HPO_Name__c":"Rhinorrhea","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000613","HPO_Synonym__c":"Extreme sensitivity of the eyes to light; Light hypersensitivity; Photodysphoria","HPO_Name__c":"Photophobia","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Redness of the skin of the face, caused by hyperemia of the capillaries in the lower layers of the skin.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001041","HPO_Synonym__c":"Blushed cheeks; Blushing; Red face; Red in the face","HPO_Name__c":"Facial erythema","Feature_System__c":"Skin System; Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Reduced ability to pass air through the nasal cavity often leading to mouth breathing.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001742","HPO_Synonym__c":"Blockage of nose; Nasal blockage; Nasal obstruction; Obstruction of nose; Stuffy nose","HPO_Name__c":"Nasal congestion","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002013","HPO_Synonym__c":"Emesis; Throwing up; Vomiting","HPO_Name__c":"Vomiting","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:57145","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A sensation of unease in the stomach together with an urge to vomit.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002018","HPO_Synonym__c":"Nausea","HPO_Name__c":"Nausea","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Disease Category":["Neurology"],"Specialist":["Neurology","Vascular Neurology","Vascular Medicine"]},"synonyms":["short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing"," short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing syndrome"," short-lasting, unilateral, neuralgiform headache attacks with conjunctival injection and tearing"," sunct (short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing) syndrome"," sunct headache"]}