{"Name":"Neuroendocrine neoplasm","DiseaseID__c":"GARD:0009316","id":9316,"encodedName":"neuroendocrine-neoplasm","IsDeleted":false,"Disease_Name_Full__c":"Neuroendocrine neoplasm","Xref_IDs__c":"128928004; 1290052006; 255046005; C0206754; C188218; C3809; D018358; DOID:169; HP:0100634; MEDGEN:64652; MONDO:0019496; ORPHA:877","USA_Estimate__c":"50,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"80,000 to 800,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":4,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0019496","Disease_Description__c":"A group of rare tumors characterized by predominantly neuroendocrine differentiation, potentially arising in most organs of the body, including the central nervous system, respiratory tract, larynx, gastrointestinal tract, thyroid, skin, breast, and urogenital system. The gastrointestinal tract and lungs are the most common primary tumor sites. Based on clinical behavior, histology, and proliferation rate, the tumors may be categorized as well differentiated (low grade to intermediate grade) neuroendocrine tumors and poorly differentiated (high grade) neuroendocrine carcinomas. They may or may not be associated with clinical hormone hypersecretion syndromes.","GARD_Name__c":"Neuroendocrine neoplasm","GARD_Synonym__c":"apudoma; nen - neuroendocrine neoplasm; neuroendocrine neoplasia; neuroendocrine tumor; neuroendocrine tumour; well-differentiated neuroendocrine tumor","Curated_Disease_Description_Source__c":"GARD:0009316","Curated_Disease_Description__c":"A neuroendocrine neoplasm (carcinoid tumor) is a type of neuroendocrine tumor that usually develops in the digestive (GI) tract (such as the stomach or intestines) or in the lungs. In some cases, a neuroendocrine neoplasm develops in another part of the body, such as the pancreas, testicle (in men), or ovary (in women). In later stages, symptoms may vary depending on where the tumor is located. Symptoms of a GI neuroendocrine neoplasm may only develop if the tumor has spread to the liver. The tumor may produce hormone-like substances that spread to the body and cause symptoms of carcinoid syndrome, such as flushing of the face and chest, diarrhea, and trouble breathing. People with a lung neuroendocrine neoplasm are less likely to have carcinoid syndrome, but may experience coughing, wheezing, or pneumonia. The tumor may also cause various symptoms if it has spread to other parts of the body. The cause of neuroendocrine neoplasms is unknown, but certain unavoidable risk factors may increase a person's chance of developing a neuroendocrine neoplasm.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"50,000","Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:877","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0019496","ORPHANET_ID__c":"ORPHA:877","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Tumor neuroendocrino","Spanish_Description_Source__c":"ORPHA:877","Spanish_Description__c":"Es un grupo de tumores poco frecuentes caracterizados por una diferenciación predominantemente neuroendocrina, que se desarrolla potencialmente en la mayoría de los órganos del cuerpo, incluido el sistema nervioso central, el tracto respiratorio, la laringe, el tracto digestivo, la tiroides, la piel, la mama y el sistema urogenital. El tracto digestivo y los pulmones son los sitios de tumores primarios más comunes. Según el comportamiento clínico, la histología y la tasa de proliferación, los tumores pueden clasificarse como tumores neuroendocrinos bien diferenciados (bajo grado bajo a grado intermedio) y carcinomas neuroendocrinos poco diferenciados (alto grado). Pueden o no estar asociados a síndromes clínicos de hipersecreción hormonal.","Spanish_Disease_Name__c":"tumor neuroendocrino","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"A neuroendocrine neoplasm (carcinoid tumor) is a type of neuroendocrine tumor that usually develops in the digestive (GI) tract (such as the stomach or intestines) or in the lungs. In some cases, a neuroendocrine neoplasm develops in another part of the body, such as the pancreas, testicle (in men), or ovary (in women). In later stages, symptoms may vary depending on where the tumor is located. Symptoms of a GI neuroendocrine neoplasm may only develop if the tumor has spread to the liver. The tumor may produce hormone-like substances that spread to the body and cause symptoms of carcinoid syndrome, such as flushing of the face and chest, diarrhea, and trouble breathing. People with a lung neuroendocrine neoplasm are less likely to have carcinoid syndrome, but may experience coughing, wheezing, or pneumonia. The tumor may also cause various symptoms if it has spread to other parts of the body. The cause of neuroendocrine neoplasms is unknown, but certain unavoidable risk factors may increase a person's chance of developing a neuroendocrine neoplasm.","Curated_Disease_Description_Source__c":"GARD:0009316","GARD_Synonym__c":"apudoma; nen - neuroendocrine neoplasm; neuroendocrine neoplasia; neuroendocrine tumor; neuroendocrine tumour; well-differentiated neuroendocrine tumor","Name":"Neuroendocrine neoplasm","Curated_USA_Estimate__c":"50,000","estimateUsa":"50,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"GO2 Foundation for Lung Cancer","Website__c":"https://go2.org/"},{"Account_Name__c":"International Neuroendocrine Cancer Alliance","Website__c":"https://incalliance.org/"},{"Account_Name__c":"American Cancer Society","Website__c":"https://www.cancer.org"},{"Account_Name__c":"Carcinoid Cancer Foundation","Website__c":"https://www.carcinoid.org/"},{"Account_Name__c":"Neuroendocrine Tumor Research Foundation","Website__c":"https://netrf.org/"},{"Account_Name__c":"Neuroendocrine Cancer UK","Website__c":"https://www.neuroendocrinecancer.org.uk/"},{"Account_Name__c":"Canadian NeuroEndocrine Tumour Society","Website__c":"https://cnets.ca/"},{"Account_Name__c":"Pancreatica","Website__c":"https://pancreatica.org/"},{"Account_Name__c":"The Healing NET Foundation","Website__c":"https://www.thehealingnet.org/"},{"Account_Name__c":"Learn Advocate Connect Neuroendocrine Tumor Society","Website__c":"https://www.lacnets.org/"},{"Account_Name__c":"NorCal CarciNet Community","Website__c":"https://norcalcarcinet.org/"},{"Account_Name__c":"Neuroendocrine Cancer Awareness Network","Website__c":"https://www.netcancerawareness.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Endocrine","Tag_Category__c":"Disease Category;Specialist","category_description":"Endocrine diseases affect hormone production or how the body responds to a specific hormone(s).","curated_tag_name":"Endocrine diseases"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:877"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.orpha.net/en/disease/detail/877","Source__c":"C0206754; MONDO:0019496; ORPHA:877","Xref__c":"ORPHA:877"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A169","Source__c":"MONDO:0019496","Xref__c":"DOID:169"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=255046005","Source__c":"MONDO:0019496","Xref__c":"255046005"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=64652","Source__c":"C0206754","Xref__c":"MEDGEN:64652"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C018358","Source__c":"C0206754; MONDO:0019496","Xref__c":"D018358"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3809","Source__c":"C0206754; MONDO:0019496","Xref__c":"C3809"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0206754","Source__c":"C0206754","Xref__c":"C0206754"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=1288045008","Source__c":"C0206754","Xref__c":"1288045008"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=1290052006","Source__c":"C0206754","Xref__c":"1290052006"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C188218","Source__c":"MONDO:0019496","Xref__c":"C188218"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=1286768001","Source__c":"C0206754","Xref__c":"1286768001"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0100634","Source__c":"C0206754","Xref__c":"HP:0100634"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=128928004","Source__c":"C0206754","Xref__c":"128928004"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0019496","Source__c":"GARD:0009316","Xref__c":"MONDO:0019496"}],"tags":{"Specialist":["Cancer - Oncologist","Endocrine"],"Disease Category":["Cancer","Endocrine"]},"synonyms":["apudoma"," nen - neuroendocrine neoplasm"," neuroendocrine neoplasia"," neuroendocrine tumor"," neuroendocrine tumour"," well-differentiated neuroendocrine tumor"]}