{"Name":"Myeloproliferative neoplasm","DiseaseID__c":"GARD:0009319","id":9319,"encodedName":"myeloproliferative-neoplasm","IsDeleted":false,"Disease_Name_Full__c":"Myeloproliferative neoplasm","Xref_IDs__c":"425333006; C1292778; C4345; DOID:2226; MEDGEN:220955; MONDO:0020076; ORPHA:98274","USA_Estimate__c":"50,000","No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":1,"World_Estimate__c":"80,000 to 800,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":1,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0020076","Disease_Description__c":"A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)","GARD_Name__c":"Myeloproliferative neoplasm","GARD_Synonym__c":"chronic myeloproliferative disease; chronic myeloproliferative disorder; chronic myeloproliferative disorder (clinical); chronic myeloproliferative neoplasm; cmpd; mpd; mpn; myeloproliferative disorder; myeloproliferative neoplasm, chronic; myeloproliferative tumor; myeloproliferative tumour","Curated_Disease_Description_Source__c":"GARD:0009319","Curated_Disease_Description__c":"Myeloproliferative neoplasms are a group of slow-growing blood cancers in which the bone marrow makes too many abnormal red blood cells, white blood cells, or platelets, which accumulate in the blood. The type of myeloproliferative disorder is based on whether too many red blood cells, white blood cells, or platelets are being made. Sometimes the body will make too many of more than one type of blood cell, but usually one type of blood cell is affected more than the others. There are 6 types of Myeloproliferative neoplasm: chronic myelogenous leukemia (CML), polycythemia vera, primary myelofibrosis (also called chronic idiopathic myelofibrosis), essential thrombocythemia, chronic neutrophilic leukemia, and chronic eosinophilic leukemia.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"50,000","Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:98274","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0020076","ORPHANET_ID__c":"ORPHA:98274","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Neoplasia mieloproliferativa","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"neoplasia mieloproliferativa","Spanish_GARD_Synonym__c":"mpd; mpn; trastorno mieloproliferativo","Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Myeloproliferative neoplasms are a group of slow-growing blood cancers in which the bone marrow makes too many abnormal red blood cells, white blood cells, or platelets, which accumulate in the blood. The type of myeloproliferative disorder is based on whether too many red blood cells, white blood cells, or platelets are being made. Sometimes the body will make too many of more than one type of blood cell, but usually one type of blood cell is affected more than the others. There are 6 types of Myeloproliferative neoplasm: chronic myelogenous leukemia (CML), polycythemia vera, primary myelofibrosis (also called chronic idiopathic myelofibrosis), essential thrombocythemia, chronic neutrophilic leukemia, and chronic eosinophilic leukemia.","Curated_Disease_Description_Source__c":"GARD:0009319","GARD_Synonym__c":"chronic myeloproliferative disease; chronic myeloproliferative disorder; chronic myeloproliferative disorder (clinical); chronic myeloproliferative neoplasm; cmpd; mpd; mpn; myeloproliferative disorder; myeloproliferative neoplasm, chronic; myeloproliferative tumor; myeloproliferative tumour","Name":"Myeloproliferative neoplasm","Curated_USA_Estimate__c":"50,000","estimateUsa":"50,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Aplastic Anemia and MDS International Foundation","Website__c":"https://www.aamds.org"},{"Account_Name__c":"HealthTree Foundation","Website__c":"https://healthtree.org/"},{"Account_Name__c":"American Cancer Society","Website__c":"https://www.cancer.org"},{"Account_Name__c":"Blood Cancer United","Website__c":"https://bloodcancerunited.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Hematology","Tag_Category__c":"Disease Category;Specialist","category_description":"Blood diseases affect the blood or blood-forming organs, including red blood cells, white blood cells, platelets, plasma, and bone marrow.","curated_tag_name":"Blood diseases"},{"Tag_Name__c":"Myeloid hemopathy","Tag_Category__c":"Account","curated_tag_name":"Blood or bone marrow disease"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:98274"}],"Diagnosis__c":[{"Type__c":"GTR","Curie__c":"MEDGEN:C0027022"},{"Type__c":"GTR","Curie__c":"MEDGEN:C1292778"}],"External_Identifier_Disease__c":[{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4345","Source__c":"C1292778; MONDO:0020076","Xref__c":"C4345"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C1292778","Source__c":"C1292778","Xref__c":"C1292778"},{"URL__c":"https://www.orpha.net/en/disease/detail/98274","Source__c":"C1292778; MONDO:0020076","Xref__c":"ORPHA:98274"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A2226","Source__c":"MONDO:0020076","Xref__c":"DOID:2226"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=425333006","Source__c":"MONDO:0020076","Xref__c":"425333006"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=220955","Source__c":"C1292778","Xref__c":"MEDGEN:220955"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=109993000","Source__c":"C1292778","Xref__c":"109993000"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0020076","Source__c":"GARD:0009319","Xref__c":"MONDO:0020076"},{"URL__c":"https://www.cancer.gov/types/myeloproliferative"}],"tags":{"Specialist":["Cancer - Oncologist","Hematology","Pediatrics"],"Disease Category":["Cancer","Hematology"],"Account":["Myeloid hemopathy"]},"synonyms":["chronic myeloproliferative disease"," chronic myeloproliferative disorder"," chronic myeloproliferative disorder (clinical)"," chronic myeloproliferative neoplasm"," cmpd"," mpd"," mpn"," myeloproliferative disorder"," myeloproliferative neoplasm, chronic"," myeloproliferative tumor"," myeloproliferative tumour"]}