{"Name":"Plasma cell leukemia","DiseaseID__c":"GARD:0009373","id":9373,"encodedName":"plasma-cell-leukemia","IsDeleted":false,"Disease_Name_Full__c":"Plasma cell leukemia","Xref_IDs__c":"128922003; 95210003; C0023484; C3180; C90.1; D007952; DOID:9513; MEDGEN:9733; MONDO:0018689; ORPHA:454714","USA_Estimate__c":"1,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"1 to 8,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":3,"No_of_Age_at_Onset__c":2,"Description_Source__c":"MONDO:0018689","Disease_Description__c":"An aggressive plasma cell neoplasm characterized by the presence of neoplastic plasma cells in the peripheral blood. It is characterized by the presence of a circulating clonal plasma cell count that exceeds 2x10^9/L or is 20% of the leukocyte differential count.","GARD_Name__c":"Plasma cell leukemia","GARD_Synonym__c":"leukaemia plasmacytic; leukemia plasmacytic; pcl; plasma cell leukemia, disease; plasma cell leukemia, morphology; plasmacytic leukaemia; plasmacytic leukemia","Curated_Disease_Description_Source__c":"GARD:0009373","Curated_Disease_Description__c":"Plasma cell leukemia (PCL) is a rare and aggressive form of multiple myeloma that involves high levels of plasma cells circulating in the peripheral blood. The signs and symptoms of PCL include aggressive clinical features, such as extramedullary disease, bone marrow failure, advanced stage disease and expression of distinct immunophenotypic markers.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"1,000","Age_at_Onset_Snippet_Text__c":"as an Adult and as an Older Adult","SourceID__c":"ORPHA:454714","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0018689","ORPHANET_ID__c":"ORPHA:454714","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Leucemia de células plasmáticas","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"leucemia de células plasmáticas","Spanish_GARD_Synonym__c":"lcp","Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Plasma cell leukemia (PCL) is a rare and aggressive form of multiple myeloma that involves high levels of plasma cells circulating in the peripheral blood. The signs and symptoms of PCL include aggressive clinical features, such as extramedullary disease, bone marrow failure, advanced stage disease and expression of distinct immunophenotypic markers.","Curated_Disease_Description_Source__c":"GARD:0009373","GARD_Synonym__c":"leukaemia plasmacytic; leukemia plasmacytic; pcl; plasma cell leukemia, disease; plasma cell leukemia, morphology; plasmacytic leukaemia; plasmacytic leukemia","Name":"Plasma cell leukemia","Curated_USA_Estimate__c":"1,000","estimateUsa":"1,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Cancer.net","Website__c":"https://www.cancer.net/"},{"Account_Name__c":"The Leukemia & Lymphoma Society","Website__c":"www.lls.org"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Hematology","Tag_Category__c":"Disease Category;Specialist","category_description":"Blood diseases affect the blood or blood-forming organs, including red blood cells, white blood cells, platelets, plasma, and bone marrow.","curated_tag_name":"Blood diseases"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Elderly","Provided_By__c":"ORPHA:454714"},{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:454714"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C007952","Source__c":"C0023484; MONDO:0018689","Xref__c":"D007952"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3180","Source__c":"C0023484; MONDO:0018689","Xref__c":"C3180"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=9733","Source__c":"C0023484","Xref__c":"MEDGEN:9733"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A9513","Source__c":"MONDO:0018689","Xref__c":"DOID:9513"},{"URL__c":"https://www.orpha.net/en/disease/detail/454714","Source__c":"C0023484; MONDO:0018689; ORPHA:454714","Xref__c":"ORPHA:454714"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0023484","Source__c":"C0023484","Xref__c":"C0023484"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=95210003","Source__c":"C0023484; MONDO:0018689","Xref__c":"95210003"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0018689","Source__c":"GARD:0009373","Xref__c":"MONDO:0018689"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/C90.1","Source__c":"MONDO:0018689","Xref__c":"C90.1"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=128922003","Source__c":"C0023484","Xref__c":"128922003"}],"tags":{"Specialist":["Cancer - Oncologist","Hematology"],"Disease Category":["Cancer","Hematology"]},"synonyms":["leukaemia plasmacytic"," leukemia plasmacytic"," pcl"," plasma cell leukemia, disease"," plasma cell leukemia, morphology"," plasmacytic leukaemia"," plasmacytic leukemia"]}