{"Name":"Takotsubo cardiomyopathy","DiseaseID__c":"GARD:0009400","id":9400,"encodedName":"takotsubo-cardiomyopathy","IsDeleted":false,"Disease_Name_Full__c":"Takotsubo cardiomyopathy","Xref_IDs__c":"441541008; C1739395; C85181; D054549; HP:0011665; I51.81; MEDGEN:366029; MONDO:0019018; ORPHA:66529","USA_Estimate__c":"50,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"80,000 to 800,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":4,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0019018","Disease_Description__c":"A rare cardiac disease characterized by acute occurrence of heart failure after an emotional or physical trigger; recovery of the wall motion abnormalities are observed within months. Symptoms are similar to acute coronary syndrome (ACS).","GARD_Name__c":"Takotsubo cardiomyopathy","GARD_Synonym__c":"acute stress cardiomyopathy; ampulla cardiomyopathy; apical ballooning syndrome; ballooning cardiomyopathy; broken heart syndrome; broken-heart syndrome; left ventricular ballooning syndrome; left ventricular transient apical ballooning; stress cardiomyopathy; stress-induced cardiomyopathy; tako tsubo syndrome; tako-tsubo cardiomyopathy; tako-tsubo syndrome; takotsubo syndrome; transient antero-apical dyskinesia; transient left ventricular apical ballooning syndrome","Curated_Disease_Description_Source__c":"GARD:0009400","Curated_Disease_Description__c":"Tako-Tsubo cardiomyopathy is a temporary condition that affects the heart. In people with this condition, extreme emotional or physical stress (i.e. intense grief, anger, surprise, illness or surgery) can lead to heart muscle failure. Symptoms of the condition mimic those of a heart attack and may include sudden chest pain, shortness of breath, and an irregular heartbeat. The cause of Tako-Tsubo cardiomyopathy is not completely understood.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"50,000","Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:66529","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0019018","ORPHANET_ID__c":"ORPHA:66529","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Miocardiopatía de tako-tsubo","Spanish_Description_Source__c":"ORPHA:66529","Spanish_Description__c":"Es una enfermedad cardíaca poco frecuente caracterizada por la aparición de insuficiencia cardíaca aguda después de un desencadenante emocional o físico, en la que la recuperación de las anomalías del movimiento de la pared se observa en un plazo de meses. Los síntomas son similares a los del síndrome coronario agudo (SCA).","Spanish_Disease_Name__c":"miocardiopatía de tako-tsubo","Spanish_GARD_Synonym__c":"miocardiopatía de takotsubo; síndrome de tako-tsubo","Category_Linearization__c":"ORPHA:97929","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Tako-Tsubo cardiomyopathy is a temporary condition that affects the heart. In people with this condition, extreme emotional or physical stress (i.e. intense grief, anger, surprise, illness or surgery) can lead to heart muscle failure. Symptoms of the condition mimic those of a heart attack and may include sudden chest pain, shortness of breath, and an irregular heartbeat. The cause of Tako-Tsubo cardiomyopathy is not completely understood.","Curated_Disease_Description_Source__c":"GARD:0009400","GARD_Synonym__c":"acute stress cardiomyopathy; ampulla cardiomyopathy; apical ballooning syndrome; ballooning cardiomyopathy; broken heart syndrome; broken-heart syndrome; left ventricular ballooning syndrome; left ventricular transient apical ballooning; stress cardiomyopathy; stress-induced cardiomyopathy; tako tsubo syndrome; tako-tsubo cardiomyopathy; tako-tsubo syndrome; takotsubo syndrome; transient antero-apical dyskinesia; transient left ventricular apical ballooning syndrome","Name":"Takotsubo cardiomyopathy","Curated_USA_Estimate__c":"50,000","estimateUsa":"50,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"American Heart Association","Website__c":"https://www.heart.org"},{"Account_Name__c":"Takotsubo Network","Website__c":"https://takotsubo.net/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cardiology","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cardiomyopathy","Tag_Category__c":"Account","curated_tag_name":"Cardiomyopathy"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:66529"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C054549","Source__c":"C1739395; MONDO:0019018","Xref__c":"D054549"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C1739395","Source__c":"C1739395","Xref__c":"C1739395"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=441541008","Source__c":"C1739395; MONDO:0019018","Xref__c":"441541008"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=366029","Source__c":"C1739395","Xref__c":"MEDGEN:366029"},{"URL__c":"https://www.orpha.net/en/disease/detail/66529","Source__c":"C1739395; MONDO:0019018; ORPHA:66529","Xref__c":"ORPHA:66529"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C85181","Source__c":"C1739395; MONDO:0019018","Xref__c":"C85181"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/I51.81","Source__c":"MONDO:0019018","Xref__c":"I51.81"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0011665","Source__c":"C1739395","Xref__c":"HP:0011665"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0019018","Source__c":"GARD:0009400","Xref__c":"MONDO:0019018"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A sensation that the heart is pounding or racing, which is a non-specific sign but may be a manifestation of arrhythmia.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001962","HPO_Synonym__c":"Heart palpitations; Missed heart beat; Palpitations; Skipped heart beat","HPO_Name__c":"Palpitations","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"A small reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle. The normal range in adults is at least 50 percent, and a mild reduction is defined as 40-49 percent.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012663","HPO_Synonym__c":"Mildly reduced ejection fraction","HPO_Name__c":"Mildly reduced left ventricular ejection fraction","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Imaging_Echocardiogram"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0004308","HPO_Synonym__c":"Ventricular arrhythmias","HPO_Name__c":"Ventricular arrhythmia","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An electrocardiographic anomaly in which the ST segment is observed to be located inferior to the isoelectric line.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012250","HPO_Name__c":"ST segment depression","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Procedure_EKG"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"Severely decreased cardiac output with evidence of inadequate end-organ perfusion (i.e., tissue hypoxia) in the presence of adequate intravascular volume.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0030149","HPO_Synonym__c":"Cardiovascular shock","HPO_Name__c":"Cardiogenic shock","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Reduced wall motion (contraction) of the apex of the left ventricle. This manifestation can be observed on echocardiography.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0031483","HPO_Synonym__c":"Left ventricular apical hypokinesis","HPO_Name__c":"Reduced contraction of the left ventricular apex","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Excluded (0%)","Feature__r":{"HPO_Description__c":"Abnormal narrowing of the coronary artery.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0005145","HPO_Synonym__c":"Narrowing of coronary artery","HPO_Name__c":"Coronary artery stenosis","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"An abnormality of the mitral valve characterized by insufficiency or incompetence of the mitral valve resulting in retrograde leaking of blood through the mitral valve upon ventricular contraction.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001653","HPO_Synonym__c":"Mitral incompetence; Mitral insufficiency; Mitral valve insufficiency; Mitral valve regurgitation","HPO_Name__c":"Mitral regurgitation","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Increased time between the start of the Q wave and the end of the T wave as measured by the electrocardiogram (EKG).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001657","HPO_Synonym__c":"Long QT syndrome; Prolong qt interval on ekg","HPO_Name__c":"Prolonged QT interval","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Procedure_EKG"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"A slower than normal heart rate (in adults, slower than 60 beats per minute).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001662","HPO_Synonym__c":"Brachycardia; Slow heartbeats","HPO_Name__c":"Bradycardia","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An electrocardiographic anomaly in which the ST segment is observed to be located superior to the isoelectric line.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012251","HPO_Name__c":"ST segment elevation","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Procedure_EKG"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the chest.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100749","HPO_Synonym__c":"Chest pain; Thoracic pain","HPO_Name__c":"Chest pain","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"The presence of chronic increased pressure in the systemic arterial system.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000822","HPO_Synonym__c":"Arterial hypertension; Systemic hypertension","HPO_Name__c":"Hypertension","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Accumulation of substantial excess body fat.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001513","HPO_Synonym__c":"Having too much body fat; Obesity","HPO_Name__c":"Obesity","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A longer than normal interval (corrected for heart rate) between the Q and T waves in the heart's cycle. Prolonged QTc can cause premature action potentials during late phase depolarizations thereby leading to ventricular arrhythmias and ventricular fibrillations.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0005184","HPO_Name__c":"Prolonged QTc interval","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Procedure_EKG"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002013","HPO_Synonym__c":"Emesis; Throwing up; Vomiting","HPO_Name__c":"Vomiting","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An increased concentration of tropnin T in the blood, which is a cardiac regulatory protein that controls the calcium mediated interaction between actin and myosin. Raised cardiac troponin concentrations are now accepted as the standard biochemical marker for the diagnosis of myocardial infarction.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0410174","HPO_Synonym__c":"Increased troponin T level in blood","HPO_Name__c":"Increased circulating troponin T concentration","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A localized outpouching of ventricular cavity that is generally associated with dyskinesia and paradoxical expansion during systole.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0006698","HPO_Name__c":"Dilatation of the ventricular cavity","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0011675","HPO_Synonym__c":"Abnormal heart rate; Arrhythmias; Cardiac arrhythmia; Cardiac arrhythmias; Cardiac rhythm disturbances; Heart rhythm disorders; Irregular heart beat; Irregular heartbeat","HPO_Name__c":"Arrhythmia","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"A transient loss of consciousness (i.e., characterized by a rapid onset, a short duration, and a spontaneous and complete recovery) due to cerebral hypoperfusion.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001279","HPO_Synonym__c":"Fainting spell","HPO_Name__c":"Syncope","Feature_System__c":"Nervous System; Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"Fluid accumulation in the lungs.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100598","HPO_Synonym__c":"Excess fluid in lungs; Lung edema; Pulmonary edema; Wet lung","HPO_Name__c":"Pulmonary edema","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"Uncontrolled contractions of muscles fibers in the left ventricle not producing contraction of the left ventricle. Ventricular fibrillation usually begins with a ventricular premature contraction and a short run of rapid ventricular tachycardia degenerating into uncoordinating ventricular fibrillations.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001663","HPO_Name__c":"Ventricular fibrillation","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Paroxysmal chest pain that occurs with exertion or stress and is related to myocardial ischemia.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001681","HPO_Name__c":"Angina pectoris","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Excluded (0%)","Feature__r":{"HPO_Description__c":"Inflammation of the myocardium.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012819","HPO_Synonym__c":"Inflammation of heart muscle","HPO_Name__c":"Myocarditis","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Difficult or labored breathing. Dyspnea is a subjective feeling only the patient can rate, e.g., on a Borg scale.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002094","HPO_Synonym__c":"Abnormal breathing; Breathing difficulty; Difficult to breathe; Difficulty breathing; Shortness of breath; Trouble breathing","HPO_Name__c":"Dyspnea","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0008180","HPO_Synonym__c":"Mildly elevated CPK; Mildly elevated creatine phosphokinase; Mildly elevated serum CK; Mildly elevated serum CPK; Mildly elevated serum phospho-CK; Mildly increased creatine kinase; Mildly increased serum creatine kinase; Moderately elevated serum CK; Moderately elevated serum CPK; Moderately increased serum creatine kinase","HPO_Name__c":"Mildly elevated creatine kinase","HPO_Feature_Type__c":"Lab"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Excluded (0%)","Feature__r":{"HPO_Description__c":"Reduction of the diameter of the coronary arteries as the result of an accumulation of atheromatous plaques within the walls of the coronary arteries, which increases the risk of myocardial ischemia.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001677","HPO_Synonym__c":"Coronary atherosclerosis; Coronary disease; Plaque build-up in arteries supplying blood to heart","HPO_Name__c":"Coronary artery atherosclerosis","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"An atrial arrhythmia characterized by disorganized atrial activity without discrete P waves on the surface EKG, but instead by an undulating baseline or more sharply circumscribed atrial deflections of varying amplitude an frequency ranging from 350 to 600 per minute.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0005110","HPO_Synonym__c":"Quivering upper heart chambers resulting in irregular heartbeat","HPO_Name__c":"Atrial fibrillation","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Low Blood Pressure, vascular hypotension.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002615","HPO_Synonym__c":"Arterial hypotension; Low blood pressure","HPO_Name__c":"Hypotension","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Reduced amplitude (height) of the QRS complex of the electrocardiogram (EKG), defined as amplitudes of all the QRS complexes in the limb leads are less than 5 mm or amplitudes of all the QRS complexes in the precordial leads less than 10 mm.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0025077","HPO_Name__c":"Decreased QRS voltage","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Procedure_EKG"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Excluded (0%)","Feature__r":{"HPO_Description__c":"Any structural abnormality of the coronary arteries.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0006704","HPO_Name__c":"Abnormal coronary artery morphology","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"A cerebrovascular accident (stroke) that occurs because of thromboembolism.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001727","HPO_Name__c":"Thromboembolic stroke","Feature_System__c":"Blood and Blood-Forming Tissue","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A form of heart failure characterized by reduced cardiac output. This may be seen in patients with heart failure owing to ischemic heart disease, hypertension, cardiomyopathy, and other causes.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0009805","HPO_Name__c":"Low-output congestive heart failure","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An inversion of the T-wave (which is normally positive).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0010872","HPO_Synonym__c":"EKG: T-wave inversion","HPO_Name__c":"T-wave inversion","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Procedure_EKG"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A deviation from the normal circulating concentration of B-type natriuretic peptide (BNP).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0031138","HPO_Synonym__c":"Abnormal B-type natriuretic peptide level","HPO_Name__c":"Abnormal circulating B-type natriuretic peptide concentration","HPO_Feature_Type__c":"Lab"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"A seizure is an intermittent abnormality of nervous system physiology characterized by a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001250","HPO_Synonym__c":"Epileptic seizure; Seizures","HPO_Name__c":"Seizure","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:66529","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Dyskinesis is used to describe ventricular muscle segments that bulge outside the left ventricular cavity during systole, as opposed to contracting inwards with the rest of the segments.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:6001073","HPO_Name__c":"Left ventricular apical dyskinesis","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Specialist":["Cardiology","Pediatrics"],"Account":["Cardiomyopathy"]},"synonyms":["acute stress cardiomyopathy"," ampulla cardiomyopathy"," apical ballooning syndrome"," ballooning cardiomyopathy"," broken heart syndrome"," broken-heart syndrome"," left ventricular ballooning syndrome"," left ventricular transient apical ballooning"," stress cardiomyopathy"," stress-induced cardiomyopathy"," tako tsubo syndrome"," tako-tsubo cardiomyopathy"," tako-tsubo syndrome"," takotsubo syndrome"," transient antero-apical dyskinesia"," transient left ventricular apical ballooning syndrome"]}