{"Name":"Hurthle cell carcinoma of thyroid","DiseaseID__c":"GARD:0009428","id":9428,"encodedName":"hurthle-cell-carcinoma-of-thyroid","IsDeleted":false,"Disease_Name_Full__c":"Hurthle cell carcinoma of thyroid","Xref_IDs__c":"423158009; C0749424; C4946; C536913; DOID:8161; MEDGEN:196672; MONDO:0011836; OMIM:607464","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":2,"No_of_Age_at_Onset__c":0,"Description_Source__c":"OMIM:607464","Disease_Description__c":"Hurthle cell carcinoma of the thyroid accounts for approximately 3% of all thyroid cancers. Although they are classified as variants of follicular neoplasms, they are more often multifocal and somewhat more aggressive and are less likely to take up iodine than are other follicular neoplasms ({4:Sanders and Silverman, 1998}).\\n\\nHurthle cell tumors, also known as oxyphil cell tumors, are composed of cells with increased numbers of mitochondria, which corresponds morphologically to their voluminous, granular, eosinophilic cytoplasm ({2:Maximo et al., 2005}).","GARD_Name__c":"Hurthle cell carcinoma of thyroid","GARD_Synonym__c":"cancer of thyroid, hurthle cell; hurthle cell carcinoma of the thyroid; hurthle cell carcinoma of the thyroid gland; hurthle cell carcinoma of thyroid gland; hurthle cell thyroid gland carcinoma; hurthle cell thyroid neoplasia; oncocytic carcinoma of the thyroid; oncocytic carcinoma of thyroid; thyroid carcinoma, hurthle cell; thyroid gland hurthle cell carcinoma; thyroid gland oncocytic follicular carcinoma; thyroid hurthle cell carcinoma; thyroid oncocytic carcinoma","Curated_Disease_Description_Source__c":"OMIM:607464","Curated_Disease_Description__c":"Hurthle cell carcinoma of the thyroid accounts for approximately 3% of all thyroid cancers. Although they are classified as variants of follicular neoplasms, they are more often multifocal and somewhat more aggressive and are less likely to take up iodine than are other follicular neoplasms. Hurthle cell tumors, also known as oxyphil cell tumors, are composed of cells with increased numbers of mitochondria, which corresponds morphologically to their voluminous, granular, eosinophilic cytoplasm.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":"OMIM:607464","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0011836","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Hurthle cell carcinoma of the thyroid accounts for approximately 3% of all thyroid cancers. Although they are classified as variants of follicular neoplasms, they are more often multifocal and somewhat more aggressive and are less likely to take up iodine than are other follicular neoplasms. Hurthle cell tumors, also known as oxyphil cell tumors, are composed of cells with increased numbers of mitochondria, which corresponds morphologically to their voluminous, granular, eosinophilic cytoplasm.","Curated_Disease_Description_Source__c":"OMIM:607464","GARD_Synonym__c":"cancer of thyroid, hurthle cell; hurthle cell carcinoma of the thyroid; hurthle cell carcinoma of the thyroid gland; hurthle cell carcinoma of thyroid gland; hurthle cell thyroid gland carcinoma; hurthle cell thyroid neoplasia; oncocytic carcinoma of the thyroid; oncocytic carcinoma of thyroid; thyroid carcinoma, hurthle cell; thyroid gland hurthle cell carcinoma; thyroid gland oncocytic follicular carcinoma; thyroid hurthle cell carcinoma; thyroid oncocytic carcinoma","Name":"Hurthle cell carcinoma of thyroid","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"American Cancer Society","Website__c":"https://www.cancer.org"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"}],"External_Identifier_Disease__c":[{"URL__c":"https://raresource.nih.gov/diseases/filter/0009428","Source__c":"RareSource"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0749424","Source__c":"C0749424","Xref__c":"C0749424"},{"URL__c":"https://www.omim.org/entry/607464","Source__c":"C0749424; MONDO:0011836","Xref__c":"OMIM:607464"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C536913","Source__c":"MONDO:0011836","Xref__c":"C536913"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A8161","Source__c":"MONDO:0011836","Xref__c":"DOID:8161"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=423158009","Source__c":"C0749424; MONDO:0011836","Xref__c":"423158009"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=196672","Source__c":"C0749424","Xref__c":"MEDGEN:196672"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0011836","Source__c":"GARD:0009428","Xref__c":"MONDO:0011836"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4946","Source__c":"C0749424; MONDO:0011836","Xref__c":"C4946"}],"GARD_Disease_Gene__c":[{"GeneSymbol__c":"NDUFA13","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true}],"tags":{"Disease Category":["Cancer"]},"synonyms":["cancer of thyroid, hurthle cell"," hurthle cell carcinoma of the thyroid"," hurthle cell carcinoma of the thyroid gland"," hurthle cell carcinoma of thyroid gland"," hurthle cell thyroid gland carcinoma"," hurthle cell thyroid neoplasia"," oncocytic carcinoma of the thyroid"," oncocytic carcinoma of thyroid"," thyroid carcinoma, hurthle cell"," thyroid gland hurthle cell carcinoma"," thyroid gland oncocytic follicular carcinoma"," thyroid hurthle cell carcinoma"," thyroid oncocytic carcinoma"]}