{"Name":"Waterhouse-Friderichsen syndrome","DiseaseID__c":"GARD:0009449","id":9449,"encodedName":"waterhouse-friderichsen-syndrome","IsDeleted":false,"Disease_Name_Full__c":"Waterhouse-Friderichsen syndrome","Xref_IDs__c":"36102002; A39.1; C1403891; C85225; D014884; DOID:9931; MEDGEN:234675; MONDO:0006015; ORPHA:100067","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":1,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":2,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0006015","Disease_Description__c":"A serious disorder characterized by massive adrenal gland hemorrhage secondary to a bacterial infection, most often Neisseria meningitidis infection. It is manifested with decreased blood pressure, shock, disseminated intravascular coagulation, and adrenocortical insufficiency.","GARD_Name__c":"Waterhouse-Friderichsen syndrome","GARD_Synonym__c":"acute adrenal insufficiency with meningococcemia; fatal pneumococcal waterhouse-friderichsen syndrome; meningococcal adrenal syndrome; meningococcal hemorrhagic adrenalitis; meningococcal waterhouse-friderichsen syndrome; waterhouse-friderichsen disease; wfs","Curated_Disease_Description_Source__c":"GARD:0009449","Curated_Disease_Description__c":"Waterhouse–Friderichsen syndrome is adrenal gland failure due to bleeding into the adrenal gland. It is usually caused by severe meningococcal infection or other severe, bacterial infection. Symptoms include acute adrenal gland insufficiency, and profound shock. Waterhouse–Friderichsen syndrome mainly occurs in children, but can occur in adults.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":"ORPHA:100067","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0006015","ORPHANET_ID__c":"ORPHA:100067","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Síndrome de waterhouse-friderichsen","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"síndrome de waterhouse-friderichsen","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:97978","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Waterhouse–Friderichsen syndrome is adrenal gland failure due to bleeding into the adrenal gland. It is usually caused by severe meningococcal infection or other severe, bacterial infection. Symptoms include acute adrenal gland insufficiency, and profound shock. Waterhouse–Friderichsen syndrome mainly occurs in children, but can occur in adults.","Curated_Disease_Description_Source__c":"GARD:0009449","GARD_Synonym__c":"acute adrenal insufficiency with meningococcemia; fatal pneumococcal waterhouse-friderichsen syndrome; meningococcal adrenal syndrome; meningococcal hemorrhagic adrenalitis; meningococcal waterhouse-friderichsen syndrome; waterhouse-friderichsen disease; wfs","Name":"Waterhouse-Friderichsen syndrome","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Endocrine","Tag_Category__c":"Disease Category;Specialist","category_description":"Endocrine diseases affect hormone production or how the body responds to a specific hormone(s).","curated_tag_name":"Endocrine diseases"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A9931","Source__c":"MONDO:0006015","Xref__c":"DOID:9931"},{"URL__c":"https://www.orpha.net/en/disease/detail/100067","Source__c":"C1403891; MONDO:0006015; ORPHA:100067","Xref__c":"ORPHA:100067"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C1403891","Source__c":"C1403891","Xref__c":"C1403891"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C014884","Source__c":"MONDO:0006015","Xref__c":"D014884"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=234675","Source__c":"C1403891","Xref__c":"MEDGEN:234675"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C85225","Source__c":"MONDO:0006015","Xref__c":"C85225"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/A39.1","Source__c":"MONDO:0006015","Xref__c":"A39.1"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=36102002","Source__c":"C1403891; MONDO:0006015","Xref__c":"36102002"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0006015","Source__c":"GARD:0009449","Xref__c":"MONDO:0006015"}],"tags":{"Disease Category":["Endocrine"],"Specialist":["Endocrine"]},"synonyms":["acute adrenal insufficiency with meningococcemia"," fatal pneumococcal waterhouse-friderichsen syndrome"," meningococcal adrenal syndrome"," meningococcal hemorrhagic adrenalitis"," meningococcal waterhouse-friderichsen syndrome"," waterhouse-friderichsen disease"," wfs"]}