{"Name":"Melioidosis","DiseaseID__c":"GARD:0009546","id":9546,"encodedName":"melioidosis","IsDeleted":false,"Disease_Name_Full__c":"Melioidosis","Xref_IDs__c":"186312003; 428111003; C0025229; C128336; D008554; DOID:5052; MEDGEN:44346; MONDO:0017775; ORPHA:31202","USA_Estimate__c":"200,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":1,"World_Estimate__c":"800,000 to 5,000,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":1,"No_of_Disease_Descriptions__c":4,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0017775","Disease_Description__c":"An infection that is caused by Burkholderia pseudomallei, which is found in soil and water; symptoms vary widely, but most commonly include fever, cough, pneumonia, arthralgia, myalgia, and skin ulceration.","GARD_Name__c":"Melioidosis","GARD_Synonym__c":"acute and fulminating melioidosis; burkholderia pseudomallei caused disease or disorder; burkholderia pseudomallei disease or disorder; burkholderia pseudomallei infectious disease; infection due to burkholderia pseudomallei; infection due to malleomyces pseudomallei; infection due to pseudomonas pseudomallei; infection due to whitmore's bacillus; nightcliff gardener's disease; pseudoglanders; subacute and chronic melioidosis; whitmore's disease","Curated_Disease_Description_Source__c":"GARD:0009546","Curated_Disease_Description__c":"Melioidosis is an infectious disease caused by the bacteria Burkholderia pseudomallei that are commonly found in the soil and water. Melioidosis is a rare disease in the United States, but it is common in tropical or subtropical areas of the world, including Southeast Asia, Africa, and Australia. The signs and symptoms of the disease can vary greatly and may mimic those of tuberculosis or common forms of pneumonia. Symptoms may include pain or swelling, fever, abscess, cough, high fever, headache, trouble breathing, and more. Although healthy people can also experience symptoms of the disease, people with certain conditions like diabetes, liver disease, kidney disease, lung disease, thalassemia, cancer, or certain autoimmune diseases may be more severely affected. Diagnosis is made by collecting blood, sputum, urine, or pus samples and growing the bacteria.","Curated_USA_Estimate_Source__c":"CDC","Curated_USA_Estimate__c":"1,000","Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:31202","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0017775","ORPHANET_ID__c":"ORPHA:31202","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Melioidosis","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"melioidosis","Spanish_GARD_Synonym__c":"infección por burkholderia pseudomallei","Category_Linearization__c":"ORPHA:68416","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Melioidosis is an infectious disease caused by the bacteria Burkholderia pseudomallei that are commonly found in the soil and water. Melioidosis is a rare disease in the United States, but it is common in tropical or subtropical areas of the world, including Southeast Asia, Africa, and Australia. The signs and symptoms of the disease can vary greatly and may mimic those of tuberculosis or common forms of pneumonia. Symptoms may include pain or swelling, fever, abscess, cough, high fever, headache, trouble breathing, and more. Although healthy people can also experience symptoms of the disease, people with certain conditions like diabetes, liver disease, kidney disease, lung disease, thalassemia, cancer, or certain autoimmune diseases may be more severely affected. Diagnosis is made by collecting blood, sputum, urine, or pus samples and growing the bacteria.","Curated_Disease_Description_Source__c":"GARD:0009546","GARD_Synonym__c":"acute and fulminating melioidosis; burkholderia pseudomallei caused disease or disorder; burkholderia pseudomallei disease or disorder; burkholderia pseudomallei infectious disease; infection due to burkholderia pseudomallei; infection due to malleomyces pseudomallei; infection due to pseudomonas pseudomallei; infection due to whitmore's bacillus; nightcliff gardener's disease; pseudoglanders; subacute and chronic melioidosis; whitmore's disease","Name":"Melioidosis","Curated_USA_Estimate__c":"1,000","Curated_USA_Estimate_Source__c":"CDC","estimateUsa":"1,000"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Infectious Disease","Tag_Category__c":"Disease Category;Specialist","category_description":"Infectious diseases are caused by bacteria, viruses, fungi, or parasites entering the body, multiplying, and spreading illness.","curated_tag_name":"Infectious diseases"},{"Tag_Name__c":"Rare Bacterial Infectious Disease","Tag_Category__c":"Cause","curated_tag_name":"Bacterial Infectious Disease"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:31202"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0025229","Source__c":"C0025229","Xref__c":"C0025229"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A5052","Source__c":"MONDO:0017775","Xref__c":"DOID:5052"},{"URL__c":"https://www.orpha.net/en/disease/detail/31202","Source__c":"C0025229; MONDO:0017775; ORPHA:31202","Xref__c":"ORPHA:31202"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C128336","Source__c":"C0025229; MONDO:0017775","Xref__c":"C128336"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=44346","Source__c":"C0025229","Xref__c":"MEDGEN:44346"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C008554","Source__c":"C0025229; MONDO:0017775","Xref__c":"D008554"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=186312003","Source__c":"MONDO:0017775","Xref__c":"186312003"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0017775","Source__c":"GARD:0009546","Xref__c":"MONDO:0017775"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=428111003","Source__c":"C0025229","Xref__c":"428111003"},{"URL__c":"https://www.cdc.gov/melioidosis/about/"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Degeneration (wear and tear) of articular cartilage, i.e., of the joint surface. Joint degeneration may be accompanied by osteophytes (bone overgrowth), narrowing of the joint space, regions of sclerosis at the joint surface, or joint deformity.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002758","HPO_Synonym__c":"Degenerative joint disease","HPO_Name__c":"Osteoarthritis","Feature_System__c":"Musculoskeletal System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Presence of viable bacteria in the blood.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0031864","HPO_Synonym__c":"Bacteria in blood culture; Bacteria in blood cultures","HPO_Name__c":"Bacteremia","HPO_Feature_Type__c":"Lab"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"An infection of bone of the foot.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001886","HPO_Synonym__c":"Foot bone infection","HPO_Name__c":"Foot osteomyelitis","Feature_System__c":"Musculoskeletal System; Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A type of infection of the skin that can be regarded as a sign of a pathological susceptibility to infection.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0032162","HPO_Name__c":"Unusual skin infection","Feature_System__c":"Skin System; Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A circumscribed area of pus or necrotic debris in the skin (within the epidermis or dermis).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0031292","HPO_Synonym__c":"Skin abscess","HPO_Name__c":"Cutaneous abscess","Feature_System__c":"Skin System; Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A bacterial infection and inflammation of the skin und subcutaneous tissues.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100658","HPO_Synonym__c":"Bacterial infection of skin; Skin infection","HPO_Name__c":"Cellulitis","Feature_System__c":"Musculoskeletal System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Acute inflammation of the lung due to an infection.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0011949","HPO_Name__c":"Acute infectious pneumonia","Feature_System__c":"Respiratory system; Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Body temperature elevated above the normal range.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001945","HPO_Synonym__c":"Fever; Hyperthermia; Pyrexia","HPO_Name__c":"Fever","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A circumscribed area of pus or necrotic debris in the liver.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100523","HPO_Synonym__c":"Hepatic abscess; Liver abscess","HPO_Name__c":"Liver abscess","Feature_System__c":"Immune System; Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0003095","HPO_Name__c":"Septic arthritis","Feature_System__c":"Musculoskeletal System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"The presence of any abnormality of the genitourinary system.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000119","HPO_Synonym__c":"Abnormality of the GU system; Genitourinary abnormality; Genitourinary tract anomalies; Genitourinary tract malformation; Urogenital abnormalities; Urogenital anomalies","HPO_Name__c":"Abnormality of the genitourinary system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"A circumscribed area of pus or necrotic debris in lung parenchyma, which leads to a cavity, and after formation of bronchopulmonary fistula, can manifest as an air-fluid level inside the cavity.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0025044","HPO_Name__c":"Lung abscess","Feature_System__c":"Respiratory system; Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"The state in which profound and widespread reduction of effective tissue perfusion leads first to reversible, and then if prolonged, to irreversible cellular injury.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0031273","HPO_Name__c":"Shock","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"Inflammation of the parotid gland.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0011850","HPO_Name__c":"Parotitis","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A collection of pus, immune cells, and other material in the brain.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0030049","HPO_Synonym__c":"Brain abscess","HPO_Name__c":"Brain abscess","Feature_System__c":"Nervous System; Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"Any abnormality of the parotid glands, which are the salivary glands that are located in the subcutaneous tissues of the face overlying the mandibular ramus and anterior and inferior to the external ear.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000197","HPO_Synonym__c":"Abnormality of parotid gland; Anomaly of the parotid gland","HPO_Name__c":"Abnormal parotid gland morphology","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Inflammation of the liver.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012115","HPO_Synonym__c":"Liver inflammation","HPO_Name__c":"Hepatitis","Feature_System__c":"Immune System; Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"The presence of inflammation of the prostate.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000024","HPO_Synonym__c":"Inflammation of the prostate","HPO_Name__c":"Prostatitis","Feature_System__c":"Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An abnormality of the spleen.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001743","HPO_Synonym__c":"Abnormality of the spleen","HPO_Name__c":"Abnormality of the spleen","Feature_System__c":"Cardiovascular System; Immune System; Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A circumscribed area of pus or necrotic debris in the parenchyma of the spleen.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0025059","HPO_Name__c":"Splenic abscess","Feature_System__c":"Cardiovascular System; Immune System; Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Inflammation of any part of the lung parenchyma.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002090","HPO_Synonym__c":"Pneumonia","HPO_Name__c":"Pneumonia","Feature_System__c":"Respiratory system; Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An infection of the upper or lower respiratory tract.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0011947","HPO_Synonym__c":"Respiratory infection; Respiratory tract infection","HPO_Name__c":"Respiratory tract infection","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:31202","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100806","HPO_Synonym__c":"Infection in blood stream","HPO_Name__c":"Sepsis","Feature_System__c":"Immune System","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Disease Category":["Infectious Disease"],"Specialist":["Infectious Disease","Pediatrics"],"Cause":["Rare Bacterial Infectious Disease"]},"synonyms":["acute and fulminating melioidosis"," burkholderia pseudomallei caused disease or disorder"," burkholderia pseudomallei disease or disorder"," burkholderia pseudomallei infectious disease"," infection due to burkholderia pseudomallei"," infection due to malleomyces pseudomallei"," infection due to pseudomonas pseudomallei"," infection due to whitmore's bacillus"," nightcliff gardener's disease"," pseudoglanders"," subacute and chronic melioidosis"," whitmore's disease"]}