{"Name":"Acute fatty liver of pregnancy","DiseaseID__c":"GARD:0009578","id":9578,"encodedName":"acute-fatty-liver-of-pregnancy","IsDeleted":false,"Disease_Name_Full__c":"Acute fatty liver of pregnancy","Xref_IDs__c":"716379000; C1455728; C537957; MEDGEN:264102; MONDO:0016573; ORPHA:243367","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0016573","Disease_Description__c":"A rare, severe complication occurring in the third trimester of pregnancy or in early postpartum period bearing a risk for perinatal and maternal mortality and characterized by jaundice, rise of hepatic injuries and evolving to acute liver failure and encephalopathy.","GARD_Name__c":"Acute fatty liver of pregnancy","GARD_Synonym__c":"aflp; aflp - acute fatty liver of pregnancy; nonalcoholic fatty liver during pregnancy","Curated_Disease_Description_Source__c":"GARD:0009578","Curated_Disease_Description__c":"Acute fatty liver of pregnancy (AFLP) is a rare and serious complication of pregnancy. It is characterized by a build-up of fat in the liver, which can lead to liver damage. The cause of AFLP is not well understood, but genetics may play a role. Symptoms generally begin in the third trimester and may include persistent nausea and vomiting, pain in the stomach or upper-right abdomen, malaise, jaundice and headache.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:243367","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0016573","ORPHANET_ID__c":"ORPHA:243367","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Hígado graso agudo del embarazo","Spanish_Description_Source__c":"ORPHA:243367","Spanish_Description__c":"Es una complicación grave aunque poco frecuente que se produce en el tercer trimestre del embarazo o en el inicio del periodo postparto. Constituye un riesgo para la mortalidad perinatal y materna, y se caracteriza por ictericia e incremento de las lesiones hepáticas, e implica una insuficiencia hepática aguda y encefalopatía.","Spanish_Disease_Name__c":"hígado graso agudo del embarazo","Spanish_GARD_Synonym__c":"aflp","Category_Linearization__c":"ORPHA:57146","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Acute fatty liver of pregnancy (AFLP) is a rare and serious complication of pregnancy. It is characterized by a build-up of fat in the liver, which can lead to liver damage. The cause of AFLP is not well understood, but genetics may play a role. Symptoms generally begin in the third trimester and may include persistent nausea and vomiting, pain in the stomach or upper-right abdomen, malaise, jaundice and headache.","Curated_Disease_Description_Source__c":"GARD:0009578","GARD_Synonym__c":"aflp; aflp - acute fatty liver of pregnancy; nonalcoholic fatty liver during pregnancy","Name":"Acute fatty liver of pregnancy","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Preeclampsia Foundation","Website__c":"https://www.preeclampsia.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Gastroenterology","Tag_Category__c":"Disease Category;Specialist","category_description":"Gastrointestinal diseases, or digestive diseases, affect the esophagus, stomach, small intestine, large intestine, liver, gallbladder, or pancreas.","curated_tag_name":"Gastrointestinal diseases"},{"Tag_Name__c":"Urogenital Disorders","Tag_Category__c":"Disease Category","category_description":"Urinary and reproductive diseases affect the kidneys, ureters, bladder, urethra, or the reproductive organs.","curated_tag_name":"Urinary and reproductive diseases"},{"Tag_Name__c":"Obstetrics / Gynecology","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Pregnancy-Related Diseases","Tag_Category__c":"Specialist","curated_tag_name":"Pregnancy-related diseases"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:243367"}],"External_Identifier_Disease__c":[{"URL__c":"https://raresource.nih.gov/diseases/filter/0009578","Source__c":"RareSource"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C1455728","Source__c":"C1455728","Xref__c":"C1455728"},{"URL__c":"https://www.orpha.net/en/disease/detail/243367","Source__c":"C1455728; MONDO:0016573; ORPHA:243367","Xref__c":"ORPHA:243367"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=716379000","Source__c":"C1455728; MONDO:0016573","Xref__c":"716379000"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=264102","Source__c":"C1455728","Xref__c":"MEDGEN:264102"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C537957","Source__c":"MONDO:0016573","Xref__c":"C537957"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0016573","Source__c":"GARD:0009578","Xref__c":"MONDO:0016573"}],"GARD_Disease_Gene__c":[{"GeneSymbol__c":"HADHA","GHR_URL__c":"https://medlineplus.gov/genetics/gene/hadha","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true}],"Inheritance__c":["Non-Mendelian inheritance"],"tags":{"Disease Category":["Gastroenterology","Urogenital Disorders"],"Specialist":["Gastroenterology","Obstetrics / Gynecology","Pregnancy-Related Diseases"]},"synonyms":["aflp"," aflp - acute fatty liver of pregnancy"," nonalcoholic fatty liver during pregnancy"]}