{"Name":"Lipodermatosclerosis","DiseaseID__c":"GARD:0009671","id":9671,"encodedName":"lipodermatosclerosis","IsDeleted":false,"Disease_Name_Full__c":"Lipodermatosclerosis","Xref_IDs__c":"410016009; C0406500; C537026; MEDGEN:140802; MONDO:0023646","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":1,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0023646","Disease_Description__c":"Lipodermatosclerosis refers to changes in the skin of the lower legs. It is a form of panniculitis (inflammation of the layer of fat under the skin). Signs and symptoms include pain, hardening of skin, change in skin color (redness), swelling, and a tapering of the legs above the ankles. The exact underlying cause is unknown; however, it appears to be associated with venous insufficiency and/or obesity. Treatment usually includes compression therapy.","GARD_Name__c":"Lipodermatosclerosis","GARD_Synonym__c":null,"Curated_Disease_Description_Source__c":"GARD:0009671","Curated_Disease_Description__c":"Lipodermatosclerosis refers to changes in the skin of the lower legs. It is a form of panniculitis (inflammation of the layer of fat under the skin). Symptoms include pain, hardening of skin, change in skin color (redness), swelling, and a tapering of the legs above the ankles. The exact underlying cause is unknown; however, it appears to be associated with venous insufficiency and/or obesity.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0023646","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Lipodermatosclerosis refers to changes in the skin of the lower legs. It is a form of panniculitis (inflammation of the layer of fat under the skin). Symptoms include pain, hardening of skin, change in skin color (redness), swelling, and a tapering of the legs above the ankles. The exact underlying cause is unknown; however, it appears to be associated with venous insufficiency and/or obesity.","Curated_Disease_Description_Source__c":"GARD:0009671","Name":"Lipodermatosclerosis","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"American Skin Association","Website__c":"https://www.americanskin.org/"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=140802","Source__c":"C0406500","Xref__c":"MEDGEN:140802"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=410016009","Source__c":"C0406500; MONDO:0023646","Xref__c":"410016009"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0406500","Source__c":"C0406500","Xref__c":"C0406500"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C537026","Source__c":"MONDO:0023646","Xref__c":"C537026"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0023646","Source__c":"GARD:0009671","Xref__c":"MONDO:0023646"}],"tags":{},"synonyms":[""]}