{"Name":"Oligodendroglioma","DiseaseID__c":"GARD:0009953","id":9953,"encodedName":"oligodendroglioma","IsDeleted":false,"Disease_Name_Full__c":"Oligodendroglioma","Xref_IDs__c":"1156974002; 443936004; C0028945; C129319; C3288; D009837; DOID:3181; HP:0033681; MEDGEN:45190; MONDO:0016695; ORPHA:251627","USA_Estimate__c":"5,000","No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"8,000 to 80,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":4,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0016695","Disease_Description__c":"A well-differentiated (WHO grade II), diffusely infiltrating neuroglial tumor, typically located in the cerebral hemispheres. It is composed predominantly of cells which morphologically resemble oligodendroglia. The neoplastic cells have rounded homogeneous nuclei and, on paraffin sections, a swollen, clear cytoplasm ('honeycomb' appearance). (Adapted from WHO)","GARD_Name__c":"Oligodendroglioma","GARD_Synonym__c":"well differentiated oligodendroglial tumor; well differentiated oligodendroglial tumour; well differentiated oligodendroglioma; who grade ii oligodendroglial neoplasm; who grade ii oligodendroglial tumor; who grade ii oligodendroglial tumour","Curated_Disease_Description_Source__c":"GARD:0009953","Curated_Disease_Description__c":"Oligodendrogliomas are brain tumors arising from oligodendrocytes, a type of cell that makes up the supportive (glial) tissue of the brain. They can be low-grade (grade II) or high-grade (grade III, also called anaplastic). While they can be found anywhere within the cerebral hemisphere, they are most common in the frontal and temporal lobes. They are generally soft, grayish-pink tumors that often contain mineral deposits (calcifications), areas of hemorrhage, and/or cysts. Common symptoms include seizures, headaches and changes in personality. Other symptoms vary by the size and location of the tumor. The exact cause of opigodendrogliomas is unknown. Some appear to have a chromosome abnormality involving loss of chromosomes 1p and 19q.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"5,000","Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:251627","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0016695","ORPHANET_ID__c":"ORPHA:251627","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Oligodendroglioma","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"oligodendroglioma","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Oligodendrogliomas are brain tumors arising from oligodendrocytes, a type of cell that makes up the supportive (glial) tissue of the brain. They can be low-grade (grade II) or high-grade (grade III, also called anaplastic). While they can be found anywhere within the cerebral hemisphere, they are most common in the frontal and temporal lobes. They are generally soft, grayish-pink tumors that often contain mineral deposits (calcifications), areas of hemorrhage, and/or cysts. Common symptoms include seizures, headaches and changes in personality. Other symptoms vary by the size and location of the tumor. The exact cause of opigodendrogliomas is unknown. Some appear to have a chromosome abnormality involving loss of chromosomes 1p and 19q.","Curated_Disease_Description_Source__c":"GARD:0009953","GARD_Synonym__c":"well differentiated oligodendroglial tumor; well differentiated oligodendroglial tumour; well differentiated oligodendroglioma; who grade ii oligodendroglial neoplasm; who grade ii oligodendroglial tumor; who grade ii oligodendroglial tumour","Name":"Oligodendroglioma","Curated_USA_Estimate__c":"5,000","estimateUsa":"5,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Oligo Nation","Website__c":"https://www.oligonation.org/"},{"Account_Name__c":"Alex's Lemonade Stand Foundation","Website__c":"https://www.alexslemonade.org/"},{"Account_Name__c":"The Healing Exchange BRAIN TRUST","Website__c":"https://braintrust.org/"},{"Account_Name__c":"American Brain Tumor Association","Website__c":"https://www.abta.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Neurology","Tag_Category__c":"Disease Category;Specialist","category_description":"Neurological diseases affect the brain, spinal cord, cranial nerves, autonomic nerves, or other peripheral nerves.","curated_tag_name":"Neurological diseases"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:251627"}],"External_Identifier_Disease__c":[{"URL__c":"https://raresource.nih.gov/diseases/filter/0009953","Source__c":"RareSource"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C009837","Source__c":"MONDO:0016695","Xref__c":"D009837"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A3181","Source__c":"MONDO:0016695","Xref__c":"DOID:3181"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=45190","Source__c":"C0028945","Xref__c":"MEDGEN:45190"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0028945","Source__c":"C0028945","Xref__c":"C0028945"},{"URL__c":"https://www.orpha.net/en/disease/detail/251627","Source__c":"C0028945; MONDO:0016695; ORPHA:251627","Xref__c":"ORPHA:251627"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3288","Source__c":"MONDO:0016695","Xref__c":"C3288"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=443936004","Source__c":"C0028945","Xref__c":"443936004"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0016695","Source__c":"GARD:0009953","Xref__c":"MONDO:0016695"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0033681","Source__c":"C0028945","Xref__c":"HP:0033681"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=1156974002","Source__c":"C0028945","Xref__c":"1156974002"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C129319","Source__c":"C0028945","Xref__c":"C129319"}],"tags":{"Specialist":["Cancer - Oncologist","Neurology","Pediatrics"],"Disease Category":["Cancer","Neurology"]},"synonyms":["well differentiated oligodendroglial tumor"," well differentiated oligodendroglial tumour"," well differentiated oligodendroglioma"," who grade ii oligodendroglial neoplasm"," who grade ii oligodendroglial tumor"," who grade ii oligodendroglial tumour"]}