{"Name":"Sertoli-Leydig cell tumor","DiseaseID__c":"GARD:0009967","id":9967,"encodedName":"sertoli-leydig-cell-tumor","IsDeleted":false,"Disease_Name_Full__c":"Sertoli-Leydig cell tumor","Xref_IDs__c":"C0206723; D018310; DOID:2997; MEDGEN:61669; MONDO:0002479","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":2,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0002479","Disease_Description__c":"A sex cord-gonadal stromal tumor consists of leydig cells; sertoli cells; and fibroblasts in varying proportions and degree of differentiation. Most such tumors produce androgens in the Leydig cells, formerly known as androblastoma or arrhenoblastoma. Androblastomas occur in the testis or the ovary causing precocious masculinization in the males, and defeminization, or virilization (virilism) in the females. In some cases, the Sertoli cells produce estrogens.","GARD_Name__c":"Sertoli-Leydig cell tumor","GARD_Synonym__c":null,"Curated_Disease_Description_Source__c":"GARD:0009967","Curated_Disease_Description__c":"Sertoli-leydig cell tumors are a cancer that starts in the female ovaries. The cancer cells produce and release a male sex hormone which may cause the development of male physical characteristics (virilization), including facial hair and a deep voice. This type of tumor is sometimes called arrhenoblastoma of the ovary or a stromal tumor. Sertoli-leydig cell tumors are rare tumors which account for less than 0.5% of all ovarian tumors. While they can be found in women of all age groups, they are most common in young women.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0002479","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Sertoli-leydig cell tumors are a cancer that starts in the female ovaries. The cancer cells produce and release a male sex hormone which may cause the development of male physical characteristics (virilization), including facial hair and a deep voice. This type of tumor is sometimes called arrhenoblastoma of the ovary or a stromal tumor. Sertoli-leydig cell tumors are rare tumors which account for less than 0.5% of all ovarian tumors. While they can be found in women of all age groups, they are most common in young women.","Curated_Disease_Description_Source__c":"GARD:0009967","Name":"Sertoli-Leydig cell tumor","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"American Cancer Society","Website__c":"https://www.cancer.org"},{"Account_Name__c":"Ovarian Cancer Research Alliance","Website__c":"https://ocrahope.org"},{"Account_Name__c":"National Ovarian Cancer Coalition","Website__c":"https://ovarian.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0206723","Source__c":"C0206723","Xref__c":"C0206723"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=61669","Source__c":"C0206723","Xref__c":"MEDGEN:61669"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C018310","Source__c":"C0206723; MONDO:0002479","Xref__c":"D018310"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A2997","Source__c":"MONDO:0002479","Xref__c":"DOID:2997"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0002479","Source__c":"GARD:0009967","Xref__c":"MONDO:0002479"}],"tags":{"Disease Category":["Cancer"]},"synonyms":[""]}