Some rare forms of diabetes result from mutations in a single gene and are called monogenic . Monogenic forms of diabetes may account for about 1 to 5 percent of all cases of diabetes in young people . In some cases of monogenic diabetes, the gene mutation is inherited; but in others, the gene mutation develops spontaneously . Most mutations in monogenic diabetes reduce the body's ability to produce insulin, a protein produced in the pancreas that is essential for the body to use glucose for energy . As a result, monogenic diabetes can easily be mistaken for type 1 diabetes .
Some tests that help differentiate monogenic diabetes from type 1 diabetes are simple and relatively inexpensive; parents of children who were diagnosed with type 1 diabetes at an early age should discuss with their physician whether such a test was conducted at the time of diagnosis, as such testing may not have been done.
A correct diagnosis that allows the proper treatment to be selected should lead to better glucose control and improved health in the long term. Testing of other family members may also be indicated to determine whether they are at risk for diabetes .
People with monogenic forms of diabetes still need to check their blood sugar levels, however, they may not need to check as often as a person with type 1 diabetes .
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My daughter was diagnosed with type 1 diabetes at three years of age. We recently learned that she may have monogenic diabetes. I have never heard if monogenic diabetes. When was monogenic diabetes discovered? Why is genetic testing important in monogenic diabetes? How is genetic for monogenic diabetes done? See answer
My child was diagnosed with type 1 diabetes mellitus when he was 6 years old. He was also an intrauterine growth retardation (IUGR) baby. I have read that IUGR can be associated with monogenic diabetes. Due to this possible connection and since there is no other family history of type 1 diabetes, should I have my child tested for monogenic diabetes? See answer