Myoepithelial carcinoma

Title

Other Names:

Malignant myoepithelioma; Myoepithelioma carcinoma

Categories:

Rare Cancers

Summary Summary

Myoepithelial carcinoma is a rare malignant (cancerous) tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues. Approximately 66% of these tumors occur in a part of the salivary gland, known as the parotid gland. The average age of diagnosis is 55 years. Symptoms of myoepithelial carcinoma usually begin with a painless mass.^[1] Other symptoms vary depending on the site of the tumor and may include: hoarseness, nasal blockage, bleeding from the nose, pain, headaches, and facial weakness and paralysis.^[2] Treatment depends on the location and stage of the tumor. Treatment options may include surgery to remove the affected tissues, radiation therapy, and chemotherapy.^[1]

Last updated: 11/18/2016

Treatment Treatment

The treatment for metastatic myoepithelial carcinoma usually begins with surgery to remove the main tumor. Radiation therapy can be used to reduce the chance that the tumor could return in the same location. There is limited evidence about the usefulness of chemotherapy in treating myoepithelial carcinoma, and there are no standard treatment guidelines.^[1]

Last updated: 11/18/2016

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Prognosis Prognosis

The prognosis for myoepithelial carcinoma likely depends on various factors and may be difficult to predict. Follow-up studies with information on prognosis are limited. One study that followed 27 patients from 9 months-17 years found that 14 individuals had recurrent tumors, 6 developed distant metastasis, 3 regional lymph node metastasis, and 10 passed away.^[3] Another study found that among 31 malignant soft tissue myoepithelial tumors, 13 recurred in the same area (42%) and 10 metastasized (32%).^[4]

Last updated: 11/18/2016

Organizations Organizations

Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.

Organizations Providing General Support

American Cancer Society
250 Williams Street NW
Atlanta, GA 30329
Toll-free: 1-800-227-2345
Website: https://www.cancer.org

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Learn More Learn More

These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

Where to Start

The American Cancer Society has developed an information page on salivary gland cancer. Click on the link to view the information page.
The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.

In-Depth Information

Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
PubMed is a searchable database of medical literature and lists journal articles that discuss Myoepithelial carcinoma. Click on the link to view a sample search on this topic.

GARD Answers GARD Answers

Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know. Submit a new question

What treatment options are available for myoepithelial carcinoma (malignant myoepithelioma)? Is there a clinical trial for treatment of this cancer? See answer
Most research indicates myoepithelial carcinoma (malignant myoepithelioma) is a rare cancer of the salivary glands. Can this cancer occur on someone's back? Also, is this a terminal illness with a short life expectancy? See answer

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References References

Salivary Gland Cancer Treatment: Myoepithelial carcinoma. National Cancer Institute Web site. September 15, 2015; https://www.cancer.gov/types/head-and-neck/hp/salivary-gland-treatment-pdq#link/_311. Accessed 11/18/2016.
M. Sherif Said. Myoepithelial Carcinoma. Medscape. September 27, 2015; http://emedicine.medscape.com/article/1720030. Accessed 11/18/2016.
Yu G; Ma D; Sun K; Li T; Zhang Y. Myoepithelial carcinoma of the salivary glands: behavior and management.. Chin Med J. 2003; 116(2):163-165. https://www.ncbi.nlm.nih.gov/pubmed/?term=12775221.
Hornick JL, Fletcher CD. Myoepithelial tumors of soft tissue: a clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters. Am J Surg Pathol. 2003 Sep;27(9):1183-96..