Low grade appendix mucinous neoplasm (LAMN) is a well differentiated mucinous adenocarcinoma that arises from the appendix. Well differentiated means when the cells of the tumor and the organization of the tumor’s tissue are almost normal. A mucinous adencarcinoma is a type of cancer that produces what is called “mucin”, which is the main component of mucus. They begin to form on the lining cells “epithelial cells” on exocrine glands with lots of mucous. LAMN is characterized by slow growth and it is associated with the development of pseudomyxoma peritonei. Unlike the high grade mucinous adenocarcinoma of the appendix, it usually does not spread beyond the peritoneum (the membrane lining the cavity of the abdomen and covering the abdominal organs) and it does not spread (metastasize) to other sites of the body. Pseudomyxoma peritonei (PMP) is a condition that occur when the appendiceal mucinous tumors spread to the peritoneum. Treatment is with surgery removing the tumor, and may include chemotherapy. To learn how a tumor grade is determined visit the National Institute of Cancer link: Tumor Grade.
Last updated: 11/5/2016
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Kurogochi T, Fujita T, Iida N, Etoh K, Ogawa M & Yanaga K. Chronic Abdominal Pain, Appendiceal Mucinous Neoplasm, and Concurrent Intestinal Endometriosis. J Med Case Reports. 2012; 6(327):http://www.medscape.com/viewarticle/777020_3.