Currently, we are not aware of an association between Niemann-Pick disease type B and cellulite. People with Niemann-Pick disease have an abnormal lipid (fat) metabolism which causes lipids to build-up in the spleen, lung, liver, bone marrow, and brain. Signs and symptoms may include enlarged liver and spleen (hepatosplenomegaly), reduced growth, frequent lung infections, and reduced numbers of blood cells involved in clotting (platelets).
Cellulite is often found in the pelvis, thighs, and abdomen. It is estimated to affect 85% to 95% of women. According to a review article on cellulite by Khan MH et al., 2010, cellulite is thought to result from the "herniation of subcutaneous fat within fibrous connective tissue." The underlying cause for this herniation is not well understood, and is likely multifaceted.