The most serious hemorrhaging that can occur in Factor XIII deficiency is in the
Females with Factor XIII deficiency who become pregnant are at high risk for miscarriage if they do not receive appropriate treatment. Men with this disorder may be sterile or have extremely low sperm counts. Replacing Factor XIII in these men does not correct sterility. Some of the less frequently seen symptoms are poor wound healing, excessive bleeding from wounds, blood blisters attached to the abdominal wall (retroperitoneal hematomas), and/or blood in the urine (hematuria).Some symptoms are seldom or never seen in people with Factor XIII deficiency, which may help to distinguish it from other bleeding disorders. These may include excessive blood loss during menstruation, hemorrhages within the eye, gastrointestinal bleeding,
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
|Medical Terms||Other Names||
|80%-99% of people have these symptoms|
|Abnormal umbilical stump bleeding||0011884|
|Reduced factor XIII activity||0008357|
|Umbilical cord hematoma||0030657|
|30%-79% of people have these symptoms|
Easy bruising[ more ]
Bleeding in brain
Bleeding within a joint
Hemarthrosis[ more ]
|Oral cavity bleeding||
Bleeding from mouth
|5%-29% of people have these symptoms|
|Bleeding with minor or no trauma||
|Delayed onset bleeding||0040232|
Nosebleed[ more ]
Abnormally heavy bleeding during menstruation
|Persistent bleeding after trauma||
Excessive bleeding after minor trauma
Frequent bleeding with trauma
Prolonged bleeding after minor trauma[ more ]
|Poor wound healing||0001058|
|Prolonged bleeding after dental extraction||0006298|
|Prolonged bleeding after surgery||
Excessive bleeding during surgery
Protracted bleeding after surgery[ more ]
|Prolonged bleeding following circumcision||0030137|
|Recurrent spontaneous abortion||0200067|
|1%-4% of people have these symptoms|
|Inflammation of the large intestine||0002037|
|Percent of people who have these symptoms is not available through HPO|
Symptoms present at birth
Bleeding within the skull
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Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
Conditions with similar signs and symptoms from Orphanet
Differential diagnoses mainly include the other congenital coagulation factor deficiencies: fibrinogen, factors II, V, VII, X, XI, VIII, IX (see these terms).
Visit the Orphanet disease page for more information.
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