This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
| Medical Terms | Other Names | Learn More: HPO ID |
|---|---|---|
| 80%-99% of people have these symptoms | ||
| Abnormal pyramidal sign | 0007256 | |
| Gait disturbance |
Abnormal gait
Abnormal walk
Impaired gait
[ more ]
|
0001288 |
| Hemiparesis |
Weakness of one side of body
|
0001269 |
|
Mental deficiency
Mental retardation
Mental retardation, nonspecific
Mental-retardation
[ more ]
|
0001249 | |
| Muscle weakness |
Muscular weakness
|
0001324 |
| Neurogenic bladder | 0000011 | |
|
Involuntary muscle stiffness, contraction, or spasm
|
0001257 | |
| Urinary bladder sphincter dysfunction | 0002839 | |
| Urinary incontinence |
Loss of bladder control
|
0000020 |
| 30%-79% of people have these symptoms | ||
| Behavioral abnormality |
Behavioral changes
Behavioral disorders
Behavioral disturbances
Behavioral problems
Behavioral/psychiatric abnormalities
Behavioural/Psychiatric abnormality
Psychiatric disorders
Psychiatric disturbances
[ more ]
|
0000708 |
| Distal sensory impairment |
Decreased sensation in extremities
|
0002936 |
| Skin ulcer |
Open skin sore
|
0200042 |
| 5%-29% of people have these symptoms | ||
| Abnormality of extrapyramidal motor function | 0002071 | |
| 0001251 | ||
|
Dementia, progressive
Progressive dementia
[ more ]
|
0000726 | |
| EMG abnormality | 0003457 | |
| Limitation of joint mobility |
Decreased joint mobility
Decreased mobility of joints
Limited joint mobility
Limited joint motion
[ more ]
|
0001376 |
| Orthostatic hypotension | 0001278 | |
| Percent of people who have these symptoms is not available through HPO | ||
| Abnormal upper motor neuron morphology |
Abnormal shape of upper motor neuron
|
0002127 |
| Abnormality of metabolism/homeostasis |
Laboratory abnormality
Metabolism abnormality
[ more ]
|
0001939 |
| Abnormality of the cerebral white matter | 0002500 | |
| Adult onset |
Symptoms begin in adulthood
|
0003581 |
| 0000007 | ||
| Cognitive impairment |
Abnormality of cognition
Cognitive abnormality
Cognitive defects
Cognitive deficits
Intellectual impairment
Mental impairment
[ more ]
|
0100543 |
| Paresthesia |
Pins and needles feeling
Tingling
[ more ]
|
0003401 |
| Peripheral axonal neuropathy | 0003477 | |
| Slow progression |
Signs and symptoms worsen slowly with time
|
0003677 |
| Spastic paraplegia | 0001258 | |
| Tetraparesis | 0002273 | |
If you need medical advice, you can look for doctors or other healthcare professionals who have experience with this disease. You may find these specialists through advocacy organizations, clinical trials, or articles published in medical journals. You may also want to contact a university or tertiary medical center in your area, because these centers tend to see more complex cases and have the latest technology and treatments.
If you can’t find a specialist in your local area, try contacting national or international specialists. They may be able to refer you to someone they know through conferences or research efforts. Some specialists may be willing to consult with you or your local doctors over the phone or by email if you can't travel to them for care.
You can find more tips in our guide, How to Find a Disease Specialist. We also encourage you to explore the rest of this page to find resources that can help you find specialists.
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
|
Conditions with similar signs and symptoms from Orphanet
|
|---|
|
The motor neuron dysfunction seen in APBD may be similar to that seen in amyotrophic lateral sclerosis (see this term). Primary urologic dysfunction, multiple sclerosis and Alzheimer's disease should also be considered, as well as other causes of adult onset myeloneuropathy and leukoencephalopathy.
Visit the
Orphanet disease page
for more information.
|
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
The NIH Undiagnosed Diseases Network Expands
September 26, 2018
2017 Million Dollar Bike Ride Pilot Grant Program
August 30, 2017
2016 Million Dollar Bike Ride Pilot Grant Program
August 15, 2016
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Is fatigue a common symptom of polyglucosan body disease? See answer
