Is fatigue a common symptom of polyglucosan body disease?
Polyglucosan body disease is a progressive neurological disorder that results in dysfunction of the upper and lower motor neurons. The motor neurons are the cells in our nervous system that control voluntary muscle action such as walking.
Generalized fatigue can be associated with motor neuron dysfunction, as well as neurological disorders in general.
The Brain and Spine Foundation, a source of information and support for individuals with neurological conditions, provides information on Fatigue and neurological conditions. Additionally, the following articles provide additional information on this topic. A link to the article abstract is provided below.
To obtain the full article, contact a medical/university library (or your local library for interlibrary loan), or order it online using the links above. The National Library of Medicine (NLM) Web site has a page for locating libraries in your area that can provide direct access to these journals (print or online). The Web page also describes how you can get these articles through interlibrary loan and Loansome Doc (an NLM document-ordering service). You can access this page at the following link http://nnlm.gov/members/. You can also contact the NLM toll-free at 888-346-3656 to locate libraries in your area.
Last updated: 6/9/2016
What is polyglucosan body disease?
Adult polyglucosan body disease (APBD) affects the nervous system. People with this disease usually begin to show signs after the age of 40. Signs and symptoms include trouble walking due to peripheral neuropathy and muscle weakness and stiffness. People with APBD also develop problems with bladder control due to damage to the bladder's nerves (neurogenic bladder). About half of people with APBD also develop dementia. APBD can be caused by mutations in the GBE1gene and inheritance is autosomal recessive. In some cases, the cause is not known. Treatment aims to improve quality of life by controlling each symptom of the disease. APBD likely shortens life expectancy, but with symptom management and supportive care, people with APBD can have years of productive life.
Last updated: 11/29/2017
We hope this information is helpful. We strongly recommend you discuss this information with your doctor. If you still have questions, please