Is fatigue a common symptom of polyglucosan body disease?
Polyglucosan body disease is a progressive neurological disorder that results in dysfunction of the upper and lower motor neurons. The motor neurons are the cells in our nervous system that control voluntary muscle action such as walking.
Generalized fatigue can be associated with motor neuron dysfunction, as well as neurological disorders in general.
The Brain and Spine Foundation, a source of information and support for individuals with neurological conditions, provides information on Fatigue and neurological conditions. Additionally, the following articles provide additional information on this topic. A link to the article abstract is provided below.
To obtain the full article, contact a medical/university library (or your local library for interlibrary loan), or order it online using the links above. The National Library of Medicine (NLM) Web site has a page for locating libraries in your area that can provide direct access to these journals (print or online). The Web page also describes how you can get these articles through interlibrary loan and Loansome Doc (an NLM document-ordering service). You can access this page at the following link http://nnlm.gov/members/. You can also contact the NLM toll-free at 888-346-3656 to locate libraries in your area.
Last updated: 6/9/2016
What is polyglucosan body disease?
Polyglucosan body disease affects the nervous system. Individuals with this condition usually begin to show signs of the disorder after the age of 40. Signs and symptoms include trouble walking due to decreased sensation in the legs (peripheral neuropathy) and muscle weakness and stiffness (spasticity). Individuals may also have trouble controlling bladder function as a result of damage to the nerves of the bladder (neurogenic bladder). Approximately half of the individuals with adult polyglucosan body disease also experience some degree of intellectual impairment. Mutations in the GBE1 gene can cause adult polyglucosan body disease. In some cases, no mutation can be found and the cause of the disease is not known. Adult polyglucosan body disease is thought to be inherited in an autosomal recessive manner. Treatment usually involves a team of specialists who can address the specific symptoms such as walking difficulties, incontinence, and intellectual impairment.
Last updated: 9/22/2015
We hope this information is helpful. We strongly recommend you discuss this information with your doctor. If you still have questions, please