What does having two copies of the A1298C mutation mean for treatment and further testing recommendations?
Having two copies of A1298C is not associated with significant health risks. We recommend that you discuss this with your doctor to determine if further testing is recommended.
Last updated: 9/27/2017
How might a MTHFR gene variants be treated?
Having MTHFR gene variants alone does not impact treatment. If a person has high homocysteine levels they should be carefully evaluated to identify all causes. Very high homocysteine levels rarely result from having the common variants alone. People with very high homocysteine levels should be carefully evaluated for other factors known to affect homocysteine, such as:
Treatments and life-style changes are given based upon the patient's circumstances. As mentioned above, homocysteine levels can rise in people with and without MTHFR gene variants if they lack folate, choline, or B vitamins (B12, B6, and riboflavin). People with concerns about their nutrition should speak with a healthcare professional. Supplements may be recommended if the person is found to have a nutritional deficiency.
Current clinical guidelines do not recommend changes in prenatal care or prenatal vitamins based upon MTHFR gene variant status alone. Women of childbearing age should take the standard dose of folate supplementation to reduce the risk of neural tube defects. Women with a previous child with a neural tube defect or a family history of neural tube defect should talk to their doctors about requirements for extra folate supplementation.
We recommend you speak with a trusted healthcare professional before taking any supplement.
Last updated: 9/22/2017
We hope this information is helpful. We strongly recommend you discuss this information with your doctor. If you still have questions, please