This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
| Medical Terms | Other Names | Learn More: HPO ID |
|---|---|---|
| 80%-99% of people have these symptoms | ||
| Autoimmunity |
Autoimmune disease
Autoimmune disorder
[ more ]
|
0002960 |
| 30%-79% of people have these symptoms | ||
| Abnormal large intestine physiology | 0012700 | |
| Ascites |
Accumulation of fluid in the abdomen
|
0001541 |
| Cirrhosis |
Scar tissue replaces healthy tissue in the liver
|
0001394 |
| Dilated superficial abdominal veins | 0030168 | |
| Elevated alkaline phosphatase of hepatic origin | 0010638 | |
| Elevated hepatic transaminase |
High liver enzymes
|
0002910 |
| Fever | 0001945 | |
| Hepatic fibrosis | 0001395 | |
| Hepatomegaly |
Enlarged liver
|
0002240 |
|
Enlarged liver and spleen
|
0001433 | |
| Palmar telangiectasia | 0100869 | |
| Portal |
0001409 | |
| Spider hemangioma | 0012522 | |
| Splenomegaly |
Increased spleen size
|
0001744 |
| Ulcerative colitis | 0100279 | |
| Weight loss | 0001824 | |
| 5%-29% of people have these symptoms | ||
| Abdominal pain |
Pain in stomach
Stomach pain
[ more ]
|
0002027 |
| Adenocarcinoma of the large intestine | 0040275 | |
| Celiac disease | 0002608 | |
| Cholangiocarcinoma |
Bile duct cancer
|
0030153 |
| Cholelithiasis |
Gallstones
|
0001081 |
| Chronic hepatic failure |
Chronic liver failure
|
0100626 |
| Congestive heart failure |
Cardiac failure
Cardiac failures
Heart failure
[ more ]
|
0001635 |
| Depressivity |
Depression
|
0000716 |
| Fatigue |
Tired
Tiredness
[ more ]
|
0012378 |
| Generalized amyotrophy |
Diffuse skeletal muscle wasting
Generalized muscle degeneration
Muscle atrophy, generalized
[ more ]
|
0003700 |
| Hepatitis |
Liver inflammation
|
0012115 |
| Hepatocellular carcinoma | 0001402 | |
| Hypoalbuminemia |
Low blood albumin
|
0003073 |
|
Yellow skin
Yellowing of the skin
[ more ]
|
0000952 | |
| Osteopenia | 0000938 | |
| 0000939 | ||
| Pancreatitis |
Pancreatic inflammation
|
0001733 |
| Pleural effusion | 0002202 | |
| Polyclonal elevation of IgM | 0003459 | |
| Prolonged prothrombin time | 0008151 | |
| Pruritus |
Itching
Itchy skin
Skin itching
[ more ]
|
0000989 |
| Renal insufficiency |
Renal failure
Renal failure in adulthood
[ more ]
|
0000083 |
| Thyroiditis |
Thyroid gland inflammation
|
0100646 |
| Type I |
Type 1 diabetes
Type I diabetes
[ more ]
|
0100651 |
| Vitamin A deficiency | 0004905 | |
| Vitamin D deficiency |
Deficient in vitamin D
|
0100512 |
| Vitamin E deficiency | 0100513 | |
| Vitamin K deficiency | 0011892 | |
| 1%-4% of people have these symptoms | ||
| Acute hepatic failure |
Acute liver failure
|
0006554 |
| 0001298 | ||
| 0100575 | ||
| Uveitis | 0000554 | |
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
|
Conditions with similar signs and symptoms from Orphanet
|
|---|
|
Differential diagnoses include other hepatic diseases, such as autoimmune hepatitis and primary biliary cholangitis. Exclusion of multiple secondary causes leading to PSC-like bile duct changes, such as IgG4-associated sclerosing cholangitis, mast cell cholangiopathy, infections, biliary calculi or trauma, and other identifiable causes of insults to the biliary tree (leading to the ERCP or MRCP features seen in PSC) is mandatory to establish the diagnosis of PSC.
Visit the
Orphanet disease page
for more information.
|
Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
NCATS Rare Diseases Are Not Rare! Challenge
October 9, 2018
The NIH Undiagnosed Diseases Network Expands
September 26, 2018
Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know. Submit a new question
What causes the pain in primary sclerosing cholangitis? Does increased pain indicate a worsening of the disease and thus the need to re-do tests? See answer
