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Transient neonatal diabetes mellitus


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Other Names:
TNDM1; TNDM; DMTN; TNDM1; TNDM; DMTN; Diabetes mellitus, transient neonatal; Chromosome 6-associated transient diabetes mellitus; Diabetes mellitus, 6q24-related transient neonatal See More
Categories:
Congenital and Genetic Diseases; Endocrine Diseases; Metabolic disorders

Summary Summary


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Transient neonatal diabetes mellitus (TNDB) is a type of diabetes that appears within the first few weeks of life but is transient; affected infants go into remission within a few months, with possible relapse to permanent diabetes in adolescence or adulthood.[1] Affected individuals have slow growth before birth followed by hyperglycemia, dehydration and failure to thrive in infancy.[2] Approximately 70% of cases are caused by the overactivity of certain genes in a region of the long (q) arm of chromosome 6 called 6q24.[3][4] These cases are referred to as 6q24-related TNDB; most (but not all) of these cases are not inherited.[4] Other genetic causes include mutations in the KCNJ11 and ABCC8 genes, which usually cause permanent neonatal diabetes.[3] Treatment may include rehydration and intravenous insulin at the time of diagnosis, followed by subcutaneous insulin.[3]
Last updated: 8/28/2012

Symptoms Symptoms


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This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.

Showing of 25 |
Medical Terms Other Names
Learn More:
HPO ID
80%-99% of people have these symptoms
Dehydration 0001944
Hypoinsulinemia 0040216
Intrauterine growth retardation
Prenatal growth deficiency
Prenatal growth retardation
[ more ]
0001511
Small for gestational age
Birth weight less than 10th percentile
Low birth weight
[ more ]
0001518
30%-79% of people have these symptoms
Macroglossia
Abnormally large tongue
Increased size of tongue
Large tongue
[ more ]
0000158
Maturity-onset diabetes of the young 0004904
Umbilical hernia 0001537
5%-29% of people have these symptoms
Abnormal heart morphology
Abnormality of the heart
Abnormally shaped heart
Heart defect
[ more ]
0001627
Abnormality of limbs
Abnormal limbs
0040064
Abnormality of the kidney
Abnormal kidney
0000077
Failure to thrive
Faltering weight
Weight faltering
[ more ]
0001508
Hearing impairment
Deafness
Hearing defect
[ more ]
0000365
Hypothyroidism
Underactive thyroid
0000821
Maternal diabetes
gestational diabetes
0009800
Muscular hypotonia
Low or weak muscle tone
0001252
Neonatal onset 0003623
Neurodevelopmental delay 0012758
Seizure 0001250
1%-4% of people have these symptoms
Diabetic ketoacidosis 0001953
Type II diabetes mellitus
Noninsulin-dependent diabetes
Type 2 diabetes
Type II diabetes
[ more ]
0005978
Percent of people who have these symptoms is not available through HPO
Autosomal dominant inheritance 0000006
Elevated hemoglobin A1c 0040217
Hyperglycemia
High blood sugar
0003074
Severe failure to thrive
Severe faltering weight
Severe weight faltering
[ more ]
0001525
Transient neonatal diabetes mellitus 0008255
Showing of 25 |
Do you have more information about symptoms of this disease? We want to hear from you.
Last updated: 1/1/2021
Do you have updated information on this disease? We want to hear from you.

Find a Specialist Find a Specialist


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If you need medical advice, you can look for doctors or other healthcare professionals who have experience with this disease. You may find these specialists through advocacy organizations, clinical trials, or articles published in medical journals. You may also want to contact a university or tertiary medical center in your area, because these centers tend to see more complex cases and have the latest technology and treatments.

If you can’t find a specialist in your local area, try contacting national or international specialists. They may be able to refer you to someone they know through conferences or research efforts. Some specialists may be willing to consult with you or your local doctors over the phone or by email if you can't travel to them for care.

You can find more tips in our guide, How to Find a Disease Specialist. We also encourage you to explore the rest of this page to find resources that can help you find specialists.

Healthcare Resources

  • To find a medical professional who specializes in genetics, you can ask your doctor for a referral or you can search for one yourself. Online directories are provided by the American College of Medical Genetics and the National Society of Genetic Counselors. If you need additional help, contact a GARD Information Specialist. You can also learn more about genetic consultations from Genetics Home Reference.

Related Diseases Related Diseases


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Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.

Conditions with similar signs and symptoms from Orphanet
Differential diagnoses include permanent NDM, DEND syndrome (epilepsy, hypotonia, and developmental delay in addition to diabetes mellitus), intermediate DEND, and Wolcott-Rallison syndrome (see these terms) as well as all other syndromic forms of neonatal diabetes mellitus.
Visit the Orphanet disease page for more information.

Research Research


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Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.

Clinical Research Resources

  • ClinicalTrials.gov lists trials that are related to Transient neonatal diabetes mellitus. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.

    Please note: Studies listed on the ClinicalTrials.gov website are listed for informational purposes only; being listed does not reflect an endorsement by GARD or the NIH. We strongly recommend that you talk with a trusted healthcare provider before choosing to participate in any clinical study.

Organizations Organizations


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Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.

Organizations Supporting this Disease

  • International Diabetes Federation (IDF)
    166 Chaussee de la Hulpe
    B-1170 Brussels, Belgium
    Belgium
    Telephone: +32-2-5385511
    Fax: +32-2-5385114
    E-mail: info@idf.org
    Website: http://www.idf.org/
  • International Society for Pediatric and Adolescent Diabetes (ISPAD)
    c/o KIT Kurfurstendamm 71
    10709 Berlin
    Germany
    Telephone: 49 30 24603213
    Fax: 49 30 24603200
    E-mail: secretariat@ispad.org

Organizations Providing General Support

  • American Diabetes Association
    2451 Crystal Drive
    Suite 900
    Arlington, VA 22202
    Toll-free: 1–800–DIABETES (342–2383)
    Fax: 703–549–6995
    E-mail: AskADA@diabetes.org
    Website: http://www.diabetes.org
Do you know of an organization? We want to hear from you.

Learn More Learn More


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These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

Where to Start

  • Genetics Home Reference (GHR) contains information on Transient neonatal diabetes mellitus. This website is maintained by the National Library of Medicine.
  • The National Kidney and Urologic Diseases Information Clearinghouse (NIDDK) conducts and supports research on a broad spectrum of diseases affecting public health. Click on the link to view information on this topic.

In-Depth Information

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
    Transient neonatal diabetes mellitus 1
    Transient neonatal diabetes mellitus 2
    Transient neonatal diabetes mellitus 3
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Transient neonatal diabetes mellitus. Click on the link to view a sample search on this topic.

GARD Answers GARD Answers


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Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know. Submit a new question

  • My son was diagnosed with neonatal diabetes mellitus. He is 15 days old and we are not sure if this is permanent or transient. I want to know what the lifespan is of babies with this illness. Also how can we find out if this diabetes is transient or permanent? See answer


Have a question? Contact a GARD Information Specialist.

References References


  1. Michel Polak. Neonatal diabetes mellitus. Orphanet. March 2007; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=224. Accessed 8/24/2012.
  2. Permanent neonatal diabetes mellitus. Genetics Home Reference. July 2011; http://ghr.nlm.nih.gov/condition/permanent-neonatal-diabetes-mellitus. Accessed 8/24/2012.
  3. Isabel Karen Temple and Deborah JG Mackay. Diabetes Mellitus, 6q24-Related Transient Neonatal. GeneReviews. December 23, 2010; http://www.ncbi.nlm.nih.gov/books/NBK1534/. Accessed 8/24/2012.
  4. 6q24-related transient neonatal diabetes mellitus. Genetics Home Reference. February 2011; http://ghr.nlm.nih.gov/condition/6q24-related-transient-neonatal-diabetes-mellitus. Accessed 8/28/2012.
Do you know of a review article? We want to hear from you.
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