Fetal indomethacin syndrome

Title

Other Names:

Antenatal indomethacin exposure; Indomethacin embryofetopathy

Categories:

Ear, Nose, and Throat Diseases; Mouth Diseases

Summary Summary

The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.

Orpha Number: 1909

Definition

Indomethacin embryofetopathy refers to the manifestations that may be observed in a fetus or newborn when the mother has taken indomethacin, a potent prostaglandin inhibitor and tocolytic agent that can cross placenta, during pregnancy. Reported adverse fetal/neonatal effects include decreased renal function resulting in oligohydramnios, closure of the ductus arteriosus, and delayed cardiovascular adaptation at birth. These effects are usually transient and reversible. Indomethacin may also be a risk factor for cerebral injury (periventricular leukomalacia) and necrotizing enterocolitisin preterm infants.

Visit the Orphanet disease page for more resources.

Last updated: 6/15/2016

Symptoms Symptoms

This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.

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Medical Terms	Other Names	Learn More: HPO ID
80%-99% of people have these symptoms
Nephropathy		0000112
Premature birth	Premature delivery of affected infants Preterm delivery [ more ]	0001622
Renal insufficiency	Renal failure Renal failure in adulthood [ more ]	0000083
Respiratory insufficiency	Respiratory impairment	0002093
5%-29% of people have these symptoms
Abnormal renal tubule morphology		0000091
Abnormality of coagulation	Abnormal blood clotting	0001928
Atrial septal defect	An opening in the wall separating the top two chambers of the heart Hole in heart wall separating two upper heart chambers [ more ]	0001631
Cardiomyopathy	Disease of the heart muscle	0001638
Hydrops fetalis		0001789
Multicystic kidney dysplasia		0000003
Oligohydramnios	Low levels of amniotic fluid	0001562
Ventricular septal defect	Hole in heart wall separating two lower heart chambers	0001629

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Last updated: 10/1/2019

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Learn More Learn More

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In-Depth Information

Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.

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