Many children with Miller-Dieker syndrome (MDS) do not live past age 2, and only a few may reach age 10. The oldest known person with MDS lived to age 17. In general, life expectancy is related to the severity of the lissencephaly. The most common cause of death is aspiration pneumonia, caused by poor control of the airways.
The developmental outlook is poor for all children with MDS, but varies slightly based on the degree of the brain malformation. The highest developmental level in affected children is the equivalent of about 3 to 5 months of age, even with good seizure control. Very rarely, a child may be able to sit without help. Children with poor seizure control may function only at or below the level of a newborn.
Last updated: 5/18/2016
We hope this information is helpful. We strongly recommend you discuss this information with your doctor. If you still have questions, please