This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
|Medical Terms||Other Names||
|80%-99% of people have these symptoms|
High blood calcium levels
Increased calcium in blood[ more ]
|Impairment of activities of daily living||0031058|
Enlarged parathyroid glands
|30%-79% of people have these symptoms|
Pain in stomach
Stomach pain[ more ]
|Decreased male libido||0040306|
Spontaneous milk flow from breast
Acid reflux disease
Heartburn[ more ]
Elevated urine calcium levels
Elevated gastrin in the blood
Increased blood gastrin[ more ]
Difficulty getting a full erection
Difficulty getting an erection[ more ]
|Large cafe-au-lait macules with irregular margins||0005605|
Multiple fatty lumps
Sore in the lining of gastrointestinal tract
|Reduced bone mineral density||
Low solidness and mass of the bones
|5%-29% of people have these symptoms|
|Abnormal circulating aldosterone||
Abnormal plasma aldosterone
Abnormal absence of menstruation
|Confetti-like hypopigmented macules||0007449|
Mental disorientation[ more ]
|Cranial nerve compression||0001293|
Enlarged thyroid gland in neck
|Growth hormone excess||0000845|
Abnormal susceptibility to fractures
Frequent broken bones
Increased bone fragility
Increased tendency to fractures[ more ]
Breakdown of bone
|Pituitary growth hormone cell adenoma||0011760|
|Proportionate tall stature||0011407|
|Short attention span||
Poor attention span
Problem paying attention[ more ]
|Shortened QT interval||0012232|
|1%-4% of people have these symptoms|
|Atypical absence status epilepticus||0011151|
|Increased serum serotonin||0003144|
|Pituitary corticotropic cell adenoma||0008291|
|Pituitary gonadotropic cell adenoma||0011759|
|Pituitary null cell adenoma||0011761|
|Pituitary thyrotropic cell adenoma||0011762|
|Pulmonary carcinoid tumor||0030445|
|Percent of people who have these symptoms is not available through HPO|
|Abnormality of the thyroid gland||
Inflammation of the esophagus
Low blood sugar
|Increased circulating cortisol level||0003118|
|Increased circulating prolactin concentration||0000870|
|Pancreatic islet cell adenoma||0008261|
Noncancerous tumor in pituitary gland
When a tumor is detected through screening, the best treatment options depend on many factors, including the size, location, and type of tumor; and whether or not the tumor is "functional" (releasing
If you need medical advice, you can look for doctors or other healthcare professionals who have experience with this disease. You may find these specialists through advocacy organizations, clinical trials, or articles published in medical journals. You may also want to contact a university or tertiary medical center in your area, because these centers tend to see more complex cases and have the latest technology and treatments.
If you can’t find a specialist in your local area, try contacting national or international specialists. They may be able to refer you to someone they know through conferences or research efforts. Some specialists may be willing to consult with you or your local doctors over the phone or by email if you can't travel to them for care.
You can find more tips in our guide, How to Find a Disease Specialist. We also encourage you to explore the rest of this page to find resources that can help you find specialists.
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
Conditions with similar signs and symptoms from Orphanet
The differential diagnosis includes other types of MEN, specifically MEN2A and MEN4 (see these terms). Primary hyperparathyroidism should also be considered.
Visit the Orphanet disease page for more information.
Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know.